A kind of nir SERS probe and its preparation method and application

Abstract

The invention discloses an NIR SERS probe including gold nanorods GNRs and a conductive polymer CP wrapping the surface of the gold nanorods GNRs. A stabilizer polyvinylpyrrolidone PVP can also be distributed on the surface of the conductive polymer CP. The probe has the advantages of low cost, simple preparation, low toxicity and stable structure, and has both imaging and therapeutic effects. The invention also discloses a preparation method of the NIR SERS probe; the preparation method has the advantage of concise process, low cost and high success rate. The invention further discloses applications of the NIR SERS probe in SERS imaging and preparation of a drug having a photothermal therapeutic effect.

Description

technical field [0001] The invention belongs to the technical field of NIR SERS, in particular to a NIR SERS probe and its preparation method and application. Background technique [0002] Raman scattering: A phenomenon of inelastic scattering of photons. When light is scattered from an atom or molecule, most of the photons are elastically scattered, which is called Rayleigh scattering. Under Rayleigh scattering, the scattered photons have the same energy, frequency and wavelength as the incoming photons. However, for a small fraction of scattered photons (approximately 1 in 10 million photons), the frequency of the scattered photon will change, usually lower than the frequency of the incident photon, due to the difference between the incident photon and the medium molecule. energy exchange takes place. This is Raman scattering. According to the Raman scattering effect, the Raman spectrum of the substance can be obtained, and each substance has its own unique Raman spect...

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Problems solved by technology

But this technology also has the following disadvantages: (1) high cost, most of the existing NIR organic dyes are chemically synthesized, and the production process is more complicated, so most of the NIR Raman probes are more expensive; PEG-SH is also expensive , the mg-level PEG-SH often costs thousands of yuan. In addition, because of the presence of sulfhydryl groups, PEG-SH is not easy to store and is easily oxidized; (2) the cytotoxicity is relatively high, and the use of organic dyes often has great Cytotoxicity, even after modifying PEG, its cytotoxicity still cannot be ignored; (3) poor structural stability, in this technology, NIR dyes are only adsorbed on the surface of GNRs by non-covalent force, which will inevitably be damaged in complex physiological environments On the other hand, the structure of GNRs itself is not stable enough, and its rod-like structure is prone to melting under high-power and long-term NIR laser irradiation.

However, this technology also has the following disadvantages: (1) The synthesis process is difficult to control. This method has high technical requirements for the experimenter, and the experimental conditions are difficult to control. Often there will be uneven packaging, and even empty SiO 2 Case

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