Hyaluronic acid functionalized astaxanthin nanoemulsion and preparation method thereof

Abstract

The invention provides a hyaluronic acid functionalized astaxanthin nanoemulsion and a preparation method thereof. The preparation method of the hyaluronic acid functionalized astaxanthin nanoemulsion comprises the following steps: S1, mixing astaxanthin oil with an oil phase to form a first mixed oil phase, wherein the weight of the astaxanthin oil accounts for less than 40% of the weight of the first mixed oil phase; S2, adding a surfactant to the first mixed oil phase and mixing evenly to form a second mixed oil phase, wherein the weight ratio of the surfactant to the first mixed oil phase is 2: 3; and S3, adding an aqueous liquid of hyaluronic acid having the concentration of less than 0.2% to the second mixed oil phase, and stirring evenly, wherein the aqueous liquid of hyaluronic acid accounts for 90% of the total weight. The hyaluronic acid functionalized astaxanthin nanoemulsion and the preparation method thereof have the advantages that no high-pressure equipment is required, the astaxanthin is embedded in the nanoemulsion by use of a low-energy nanoemulsion preparation method so that the stability of the astaxanthin can be improved, the use of organic solvents such as acetone can be avoided, and meanwhile, the aqueous liquid of hyaluronic acid is utilized to increase of the rate of the astaxanthin nanoemulsion penetrating through the epidermis and improve the thermal stability of the astaxanthin in the nanoemulsion.

Description

[0001] technical field [0002] The invention relates to a preparation method of a nanoemulsion carrier used for hydrophobic substance astaxanthin, in particular to a hyaluronic acid functionalized astaxanthin nanoemulsion preparation and a preparation method thereof. [0003] Background technique [0004] Astaxanthin is a keto carotenoid with the molecular formula C 40 h 52 o 4 , The relative molecular weight is 596.86. Astaxanthin has a strong antioxidant capacity, which is 550 times that of vitamin E and 10 times that of β-carotene, and many products of astaxanthin have been proven to be safe and effective, so it is widely used in medicine, food and cosmetics. market and huge development potential. [0005] Astaxanthin is a hydrophobic substance, which is easily oxidized in the environment and cannot withstand high temperature and pressure, so the application of astaxanthin is limited. In the prior art, when preparing astaxanthin carriers, astaxanthin oil is gen...

AI Technical Summary

Problems solved by technology

When using nanoemulsion as the carrier of astaxanthin, if the nanoemulsion cannot penetrate the epidermis quickly, it will deposit on the skin surface, especially when the surfactant concentration is high, it is easy to cause skin allergies

Images