Gardenia extract and preparation method thereof

A gardenia extract, extraction method technology, applied in chemical instruments and methods, pharmaceutical formulations, plant raw materials, etc., can solve the problem that crocin components are unstable to light and heat, and reduce the cost of crocin components. , long extraction time and other problems, to achieve the effect of being beneficial to the separation and purification process, improving product quality and added value, and shortening extraction time

Inactive Publication Date: 2014-09-03
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] Since the crocin components are unstable to light and heat, the crocins in gardenia medicinal materials are mostly extracted by warm soaking method, which takes a long time and low efficiency.
If can provide a kind of extraction method that can effectively extract crocin from Gardenia jasminoides, and the impurity content is little, will be able to bring possibility for reducing the cost of crocin components

Method used

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  • Gardenia extract and preparation method thereof
  • Gardenia extract and preparation method thereof
  • Gardenia extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 extraction method of the present invention

[0039] Take gardenia, add 10 times the amount of water, and extract by boiling at 50°C for 3 times under reduced pressure, each time for 1.5h, and combine the extracts.

Embodiment 2

[0040] The investigation of embodiment 2 gardenia extracting method

[0041] 1 Instruments and reagents

[0042] Agilent1200 high performance liquid chromatograph series (Agilent Company of the United States); Mettler AE240 1 / 100,000 electronic balance (Germany Mettler); FA1104 1 / 10000 electronic balance (Shanghai Balance Instrument Factory); KQ3200 ultrasonic cleaner (Kunshan City Ultrasonic Instrument Co., Ltd.); SHZ-D (Ⅲ) circulating water vacuum pump (Gongyi Yuhua Instrument Co., Ltd.); constant temperature water bath (Beijing Zhongxing Weiye Instrument Co., Ltd.); RE-2000 rotary evaporator (Shanghai Yarong Biochemical Instrument Factory), ALPHA1-4LSC Freeze Dryer (CHRIST Company), PHS-3E PH Meter (Shanghai Precision Scientific Instrument Co., Ltd.); Malvern Nano Particle Size Analyzer (Model Nano-ZS).

[0043] Gardenia medicinal material (Sichuan Kelun Natural Pharmaceutical Co., Ltd.); geniposide reference substance (batch number: 110749-200714, China Institute for the ...

Embodiment 3

[0088] Example 3 Fingerprint Spectrum Research of Gardenia Extract

[0089] Preparation of the test solution Weigh 30g of gardenia coarse powder, add 10 times the amount of water, reflux and extract 3 times, each time for 1.5h, filter, combine the filtrate, set the volume to 1000mL, draw 1mL to a 25mL measuring bottle, and set methanol to content, shake well, and use it as the test solution of gardenia high-temperature extract.

[0090] Weigh 30g of Gardenia coarse powder, add 10 times the amount of water, under reduced pressure at 50°C, reflux extraction 3 times, each time for 1.5h, filter, combine the filtrate, set the volume to 1000mL, draw 1mL into a 25mL measuring bottle, methanol Dilute to volume, shake well, and use it as the test solution of gardenia low temperature extract.

[0091] Preparation of Reference Substance Solution Accurately weigh an appropriate amount of reference substance of geniposide and crocin Ⅰ into a 10mL measuring bottle, and configure methanol t...

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Abstract

The invention provides an extracting method of gardenia, comprises the following steps: taking gardenia, adding water, boiling to extract at 50 DEG C at reduced pressure, combining the extracting solution to obtain the gardenia extract. The invention further provides the gardenia extract and a preparation method thereof. The invention further provides a detection method of the gardenia extract. The gardenia extract provided by the invention can be extracted at low-temperature boiling dynamic condition, the crocin I content in the extract is improved, other impurity dissolving-out quantity is reduced, and the extract quality is improved. The detection method provided by the invention is capable of effectively separating a plurality of components in the gardenia extract, the spike is good, the base line is stable, and a reliable basis is provided for controlling the quality of the gardenia extract.

Description

technical field [0001] The invention relates to a gardenia extract, which belongs to the field of pharmaceutical preparations. Background technique [0002] Gardenia is the dried and mature fruit of Gardenia jasminoides Ellis, a Rubiaceae plant. It is a commonly used traditional Chinese medicine in clinical practice. It can relieve fire and trouble, clear away heat and dampness, cool blood and detoxify when taken internally, and has the effects of reducing swelling and relieving pain when used externally. [0003] Gardenia contains active ingredients such as iridoid glycosides (such as iridoid glycosides), terpenoid glycosides (such as crocin) and organic acids. Among them, the crocin components include crocetin Ⅰ, crocin Ⅱ and crocin Ⅲ, etc., which are common compounds contained in gardenia and saffron, a precious Chinese medicinal material, and have inhibitory Pharmacological effects such as growth of tumor cells, treatment of cardiovascular diseases, protection of liver ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744G01N30/88C09B61/00C09B67/54A61K131/00
Inventor 韩丽杨明黄娟张定堃杨秀梅陈晓东
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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