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A kind of preparation method of epimedium wall breaking preparation

A technology of epimedium and preparations, which is applied in the field of preparation of epimedium-broken preparations, can solve the problems of incomplete decoction of active ingredients, easy destruction of heat-sensitive ingredients, and increase of powder specific surface area, so as to improve the utilization rate of active ingredients, Easy to disintegrate and disperse, strong stability effect

Active Publication Date: 2018-07-17
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using the traditional decoction method, it is easy to destroy its heat-sensitive components. On the other hand, the decoction of the active ingredients is not complete, resulting in the loss of active ingredients.
The preparation of epimedium into superfine powder of epimedium is beneficial to improve the utilization rate of active ingredients, but at the same time, due to the increase of powder specific surface area, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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  • A kind of preparation method of epimedium wall breaking preparation
  • A kind of preparation method of epimedium wall breaking preparation
  • A kind of preparation method of epimedium wall breaking preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Take epimedium medicinal material, coarsely pulverize it to about 100 mesh coarse powder, and superfinely pulverize it into 90% of the superfine powder with particle size less than or equal to 45 μm, add ethanol-water solution (the mass fraction of ethanol is 30% ) soft material by wet method, the ratio of solution to superfine powder is 0.9:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules. The wet granules were transferred to a hot air circulation oven, set the drying temperature to 85°C, dried for 2.5 hours until dry, and the whole granules were sieved to obtain the epimedium wall-broken preparation.

[0038]

[0039] Note: The full score is 10.

Embodiment 2

[0041]Take epimedium medicinal material, coarsely pulverize it to about 100 mesh coarse powder, and superfinely pulverize it into 90% of the superfine powder with a particle size less than or equal to 45 μm, add ethanol-water solution (the mass fraction of ethanol is 65%) ) soft material by wet method, the ratio of solution to superfine powder is 1.4:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 0.8MPa to make wet granules , the wet granules were transposed into a vacuum microwave drying oven, the drying temperature was set at 45°C, and dried for 0.75h until dry.

[0042]

[0043] Note: The full score is 10.

Embodiment 3

[0045] Take epimedium medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and superfinely pulverize it into a powder in which 90% of the particles in the superfine powder have a particle size less than or equal to 45 μm, add ethanol-water solution (the mass fraction of ethanol is 90%) ) soft material by wet method, the ratio of solution to superfine powder is 1.5:1 (by weight), after mixing, pre-installed with a 30-mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet granules , the wet granules were placed in a hot air circulation oven, the drying temperature was set at 85°C, and dried for 2.5 hours until dry.

[0046]

[0047] Note: The full score is 10.

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Abstract

The invention relates to the technical field of Chinese herbal preparations, specifically to a wall-broken epimedium preparation. A preparation method for the wall-broken epimedium preparation comprises the following steps: crushing epimedium into wall-broken powder; then carrying out ethanol-water wet granulation by controlling the mass of an ethanol solution and the wall-broken powder; carrying out extrusion forming at a certain rotating speed; and then carrying out drying. The preparation method has a high granulation rate; and the prepared wall-broken epimedium preparation has high bioavailability, good stability and good disintegration performance.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of a wall-breaking preparation of Epimedium. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/296A61K9/16A61J3/00
Inventor 成金乐陈勇军梁学良钱锦花劳悦富
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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