Drug coating used for drug eluting stent and preparation method and application thereof

A technology for drug coating and eluting stents, which is applied in the field of medicine and can solve problems such as obstacles to the application of stent coatings, slow dissolution rate, and difficulty in baicalin.

Active Publication Date: 2014-10-08
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, baicalin is insoluble in water and the dissolution rate is slow, these characteristics hinder its application as a stent coating drug

Method used

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  • Drug coating used for drug eluting stent and preparation method and application thereof
  • Drug coating used for drug eluting stent and preparation method and application thereof
  • Drug coating used for drug eluting stent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1 Preparation of a baicalin phospholipid complex

[0078] Weigh 15g of baicalin, 60g of soybean lecithin, add 1000mL of absolute ethanol, place in a constant temperature water bath at 55°C for 2 hours with magnetic stirring, and recombine the reaction liquid under reduced pressure to recover absolute ethanol, dry under reduced pressure, and dissolve the obtained solid in an appropriate amount of Chloroform, after fully dissolving, filtered, and the filter residue was washed several times with a small amount of chloroform, and the filtrate recovered chloroform under reduced pressure, and dried in vacuum to obtain 74.73 g of the target product. Calculated according to Formula 1, the inclusion rate is 98.2%.

Embodiment 2

[0079] Example 2 A drug coating for drug-eluting stents

[0080] Comprising polylactic acid-glycolic acid copolymer (PLGA) and the baicalin phospholipid complex prepared in Example 1, the quality of the baicalin phospholipid complex is 10% of the quality of the polylactic acid-glycolic acid copolymer; wherein the The molecular weight of polylactic acid-glycolic acid copolymer is 60000, and the ratio of lactic acid monomer and glycolic acid monomer is lactic acid (LA):glycolic acid (GA)=60:40. Prepared by:

[0081] Weigh 1 g of PLGA (LA: GA=60:40), 0.1 g of the baicalin phospholipid complex prepared in Example 1, dissolve PLGA into a 5% (w / v) solution with chloroform, and then add the baicalin phospholipid complex , stirred with a magnetic stirrer until clarified, left to stand after ultrasonic degassing, poured into a glass dish, evaporated the solvent naturally and dried in vacuum for 48 hours.

Embodiment 3

[0082] Example 3 A drug coating for drug-eluting stents

[0083] Comprising polylactic acid-glycolic acid copolymer (PLGA) and the baicalin phospholipid complex prepared in Example 1, the quality of the baicalin phospholipid complex is 5% of the polylactic acid-glycolic acid copolymer quality; wherein the The molecular weight of polylactic acid-glycolic acid copolymer is 60000, and the ratio of lactic acid monomer and glycolic acid monomer is lactic acid (LA):glycolic acid (GA)=60:40. Prepared by:

[0084] Weigh 1 g of PLGA (LA: GA=60:40), 0.05 g of the baicalin phospholipid complex prepared in Example 1, dissolve PLGA into a 5% (w / v) solution with chloroform, and then add the baicalin phospholipid complex , stirred with a magnetic stirrer until clarified, left to stand after ultrasonic degassing, poured into a glass dish, evaporated the solvent naturally and dried in vacuum for 48 hours.

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Abstract

The invention provides a drug coating used for a drug eluting stent, and the drug coating comprises a polylactic acid-hydroxyacetic acid copolymer and a baicalin phospholipid complex; the baicalin phospholipid complex mass is not greater than 15% of the polylactic acid-hydroxyacetic acid copolymer mass, the molecular weight of the polylactic acid-hydroxyacetic acid copolymer is 10000 to 100000, the polylactic acid monomer and hydroxyacetic acid monomer ratio is lactic acid: hydroxyacetic acid = 50:50 ~ 75:25. The invention also provides a preparation method of the drug coating. The invention also provides a preparation method of the drug coating, and the drug coating can promote the growth of normal endothelial cells, inhibit vascular smooth muscle cell proliferation, and effectively prevent the vascular restenosis after the stent is implanted.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a drug coating for a drug-eluting stent and a preparation method and application thereof. Background technique [0002] At present, vascular stents have become a common treatment method for the treatment of vascular stenosis and insufficient blood supply to important organs caused by various reasons. In clinical operations, vascular stents are generally placed in the lesioned segment on the basis of lumen balloon dilatation to support the stenotic and occluded segment of the vessel, reduce elastic recoil and reshaping of the vessel, and maintain smooth blood flow in the lumen. Vascular stents are mainly divided into coronary stents, cerebrovascular stents, renal artery stents, and aortic stents according to different implantation positions. Studies have shown that due to the local excessive healing response of blood vessels to balloon injury, including early vascular elastic ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61L31/10A61L31/16
Inventor张海燕黄楠杨明王欣方洋罗光明
OwnerJIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE