Halogenated tetrazolium acetophenone compound, its preparation method and use

A technology of compounds and uses, applied in the field of drugs related to thrombosis diseases, can solve problems such as high bleeding risk
CN104086502BActive Publication Date: 2015-10-14珠海优润医药科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
珠海优润医药科技有限公司
Publication Date
2015-10-14

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Abstract

The invention relates to the field of thrombotic disease related drugs and particularly relates to novel PAR (Protease Activated Receptor)-1 antagonists with halogenated tetrazole acetophenone structures, preparation methods of the PAR-1 antagonists, pharmaceutical compositions containing the PAR-1 antagonists and applications of the PAR-1 antagonists to preparation of drugs for treating thrombotic diseases. The group R is defined as the specification.
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Description

technical field

[0001] The invention relates to the field of drugs related to thrombosis diseases. Specifically, the present invention relates to a new class of halogenated tetrazole-containing acetophenone-containing PAR-1 antagonists with therapeutic effects on thrombotic diseases, their preparation methods, and pharmaceutical compositions containing them. Background technique

[0002] Protease Activated Acceptor-1 (PAR-1) is a new target of anti-platelet antithrombotic drugs discovered recently. Protease-activated receptor 1 is also called thrombin receptor. After thrombin is activated by the coagulation chain, it acts on platelets through PAR-1 receptors to activate platelets, causing platelet aggregation and causing thrombus and coagulation. The thrombus induced by PAR-1 is rich in platelet components, which is the main cause of arterial thrombus. PAR-1 antagonists can block thrombin from activating platelets, thereby blocking arterial thrombus formation, and can be u...

Claims

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