Postoperation anti-infectious composite electrostatic-spinning nanometer fiber-film sheet for repairing hernia and preparation method thereof

A nanofiber membrane and electrospinning technology, applied in surgery, medical science, etc., can solve problems such as insufficient support strength, intolerance to infection, easy damage to the abdominal wall, etc., to prevent infection and inflammation, reduce pain, and have high support strength Effect

Inactive Publication Date: 2014-10-15
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a composite electrostatic composite anti-infection device with high support strength and good flexibility for the defects of insufficient support strength, easy damage to the abdominal wall and intolerance to infection in the existing hernia repair sheet. Spun Nanofiber Membrane Hernia Repair Piece

Method used

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  • Postoperation anti-infectious composite electrostatic-spinning nanometer fiber-film sheet for repairing hernia and preparation method thereof
  • Postoperation anti-infectious composite electrostatic-spinning nanometer fiber-film sheet for repairing hernia and preparation method thereof
  • Postoperation anti-infectious composite electrostatic-spinning nanometer fiber-film sheet for repairing hernia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] (1) Dissolve polyvinylidene fluoride in a mixed solvent of N,N-dimethylformamide (DMF) and acetone (Acetone), the volume ratio of DMF / Acetone in the mixed solvent is 5 / 5; Stir at 50°C for 12 hours to fully dissolve the polyvinylidene fluoride and obtain a polyvinylidene fluoride electrospinning solution with a volume concentration of 150 mg / mL;

[0094] (2) Inject the polyvinylidene fluoride electrospinning solution obtained in step (1) into the 5mL syringe of the electrospinning device, use a 5# needle, place the syringe in the propeller, and cover the grounded surface with aluminum foil or tinfoil The flat receiving device is located directly below the 5# needle, adjust the distance between the flat receiving device and the 5# needle to be 15cm, adjust the advancing rate to 40μL / min, adjust the voltage to 15kV, and polyvinylidene fluoride electrospinning Under the action of an electrostatic field, the liquid sprays out nanofibers and falls on the surface of the flat r...

Embodiment 2

[0100] (1) Dissolve polyethylene terephthalate (PET) in a mixed solvent of trifluoroacetic acid and dichloromethane, the volume ratio of the mixed solvent is 5 / 5; stir at a temperature of 50°C for 12 hours , so that PET is fully dissolved and uniform, and a PET electrospinning solution with a volume concentration of 150 mg / mL is obtained;

[0101] (2) Inject the PET electrospinning solution obtained in step (1) into the 5mL syringe of the electrospinning device, use a 5# needle, place the syringe in the propeller, and place the flat surface covered with aluminum foil or tinfoil to receive The device is located directly below the 5# needle, adjust the distance between the flat receiving device and the 5# needle to 15cm, adjust the advancing rate to 7μL / min, adjust the voltage to 25kV, the effect of the PET electrospinning liquid on the electrostatic field The nanofibers are ejected from the bottom and fall on the surface of the flat plate receiving device to obtain a PET nanofi...

Embodiment 3

[0106] (1) Dissolve polyvinylidene fluoride in a mixed solvent of N,N-dimethylformamide (DMF) and acetone (Acetone), and the volume ratio of DMF / Acetone in the mixed solvent is 7 / 3; at temperature Stir at 50°C for 12 hours to fully dissolve the polyvinylidene fluoride and obtain a polyvinylidene fluoride electrospinning solution with a volume concentration of 150 mg / mL;

[0107] (2) Inject the polyvinylidene fluoride electrospinning solution obtained in step (1) into the 5mL syringe of the electrospinning device, use a 5# needle, place the syringe in the propeller, and cover the grounded surface with aluminum foil or tinfoil The flat receiving device is located directly below the 5# needle, adjust the distance between the flat receiving device and the 5# needle to be 15cm, adjust the advancing rate to 25μL / min, adjust the voltage to 15kV, polyvinylidene fluoride electrospinning Under the action of an electrostatic field, the liquid sprays out nanofibers and falls on the surfac...

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Abstract

The invention relates to a postoperation anti-infectious composite electrostatic-spinning nanometer fiber-film sheet for repairing hernia and a preparation method thereof. The hernia-repairing sheet comprises a polymer nanometer fiber-membrane base sheet prepared through an electrostatic spinning method, and a biodegradable high-molecular nanometer fiber functional membrane which is connected with the polymer nanometer fiber-membrane base sheet, is loaded with an anti-infectious medicine and is obtained through an electrostatic spinning method. The polymer nanometer fiber-membrane base sheet is soft and good in mechanical properties, does not cause damage of internal organs and enables an internal organ to be fixedly disposed at a postoperation recovery position. The electrostatic-spinning nanometer fiber functional membrane loaded with the anti-infectious medicine has appropriate degradation speed, and the anti-infectious medicine is gradually released along with degradation of the material, so that postoperation infection and inflammation caused by wound pollution are effectively prevented. The hernia-repairing sheet is capable of effectively reducing inflammation reaction caused by postoperation infection and reducing patient pain after being implanted into a human body for repairing hernia.

Description

technical field [0001] The invention relates to a composite electrospinning nanofiber membrane hernia repair sheet for anti-infection after clinical operations, in particular to a composite electrospinning nanofiber membrane substrate and a load cell connected to the electrospinning nanofiber membrane substrate. A composite hernia repair sheet of electrospun nanofiber functional membrane of anti-infective drugs, and a preparation method of the composite electrospun nanofiber membrane hernia repair sheet for anti-infection after clinical operation. Background technique [0002] A hernia is also called a hernia or intestinal gas. Simply put, a hernia is a tear or hole in the musculature of the abdominal wall through which an organ or tissue, such as the patient's small intestine, protrudes from its original location and protrudes into other parts of the body. If it is not treated in time, the original abdominal wall defect will become larger and larger. In severe cases, there...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/04A61L31/16
Inventor 郑建芬王伟红韩志超
Owner INST OF CHEM CHINESE ACAD OF SCI
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