Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion
A technology of nanomaterials and tumor blood vessels, which is applied in the field of medicine, can solve problems such as serious side effects and limit widespread use, and achieve the effect of avoiding harm
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[0046] Example 1: AuSiO 2 Experiment of bubble generation in aqueous solution under laser action
[0047] Such as image 3 As shown, AuSiO 2 Aqueous solution (concentration 25mg / mL) at 760nm laser pulse (average power 500mW, 16W / cm 2 ) Under the action of a large number of bubbles, indicating that the gold nanoparticles can generate heat under the action of the laser pulse, because the outside is wrapped with a layer of thermal insulation SiO 2 The layer does not exchange fast energy with the outside. When the internal heat accumulates to a certain extent, an explosion occurs. The sample after laser treatment no longer produces explosive effects.
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[0048] Example 2: AuSiO 2 Nanomaterials for tumor treatment and effect verification under laser action
[0049] 1. Establish an animal model of tumor-bearing mice:
[0050] The ascites of mice inoculated with H22 hepatocarcinoma cell line was extracted from the abdominal cavity, and the supernatant was removed by centrifugation. The inoculated cell concentration was 10 7 50μL of cell suspension per mL was placed under the skin of the right thigh of each mouse. After 5-7 days of growth, the tumor size is about 5mm for experiment.
[0051] 2. Animal experiment in vivo magnetic resonance imaging and tumor treatment experiment:
[0052] AuSiO injection via tail vein 2 200 μL of the aqueous solution (concentration 25 mg / mL, of which the concentration of Au is 10 mg / kg) was placed in the tumor-bearing mice. A 760nm laser pulse was applied to the tumor site for 30 minutes, and the imaging conditions of tumor tissue, kidney and liver were collected at each time point.
[0053] Figure 4 In or...
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