Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion

A technology of nanomaterials and tumor blood vessels, which is applied in the field of medicine, can solve problems such as serious side effects and limit widespread use, and achieve the effect of avoiding harm

Active Publication Date: 2014-11-05
赤峰福纳康生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the VDAs candidate drugs were found to have relatively serious side effects, such as zibuxostat, CA-1P and MPC-6827 and other phase I/II clinical trials reported cardiovas

Method used

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  • Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion
  • Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion
  • Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0046] Example 1: AuSiO 2 Experiment of bubble generation in aqueous solution under laser action

[0047] Such as image 3 As shown, AuSiO 2 Aqueous solution (concentration 25mg / mL) at 760nm laser pulse (average power 500mW, 16W / cm 2 ) Under the action of a large number of bubbles, indicating that the gold nanoparticles can generate heat under the action of the laser pulse, because the outside is wrapped with a layer of thermal insulation SiO 2 The layer does not exchange fast energy with the outside. When the internal heat accumulates to a certain extent, an explosion occurs. The sample after laser treatment no longer produces explosive effects.

Example Embodiment

[0048] Example 2: AuSiO 2 Nanomaterials for tumor treatment and effect verification under laser action

[0049] 1. Establish an animal model of tumor-bearing mice:

[0050] The ascites of mice inoculated with H22 hepatocarcinoma cell line was extracted from the abdominal cavity, and the supernatant was removed by centrifugation. The inoculated cell concentration was 10 7 50μL of cell suspension per mL was placed under the skin of the right thigh of each mouse. After 5-7 days of growth, the tumor size is about 5mm for experiment.

[0051] 2. Animal experiment in vivo magnetic resonance imaging and tumor treatment experiment:

[0052] AuSiO injection via tail vein 2 200 μL of the aqueous solution (concentration 25 mg / mL, of which the concentration of Au is 10 mg / kg) was placed in the tumor-bearing mice. A 760nm laser pulse was applied to the tumor site for 30 minutes, and the imaging conditions of tumor tissue, kidney and liver were collected at each time point.

[0053] Figure 4 In or...

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Abstract

The invention discloses novel application of a nano material. The novel application is in the preparation of tumor vascular occlusion agent. The nano material has the following properties: (1) surface hydrophilicity is provided; (2) surface electronegativity is provided; (3) the nano material with size between 50-250nm and rigidity can not easily pass the holes on tumor blood vessels and can be stuck in the holes; and (4) the material is able to absorb external radiation energy, internally transforms the energy into heat, and accumulates the heat, so that the morphology and structure of the nano material drastically change. During the treatment, the nano material is injected into tumor-bearing bodies, and then radiation is applied to the tumor site, so that the nano material absorbs radiation energy and the internal temperature rises rapidly; when the temperature is accumulated to a certain extent, the morphology and structure of the nano material change (explosion or rapid expansion of volume), resulting in change of morphological structure or function of tumor vascular endothelial cells, and destruction of the tumor blood vessels.

Description

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Claims

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Application Information

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Owner 赤峰福纳康生物技术有限公司
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