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Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion

A technology of nanomaterials and tumor blood vessels, which is applied in the field of medicine, can solve problems such as serious side effects and limit widespread use, and achieve the effect of avoiding harm

Active Publication Date: 2014-11-05
赤峰福纳康生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the VDAs candidate drugs were found to have relatively serious side effects, such as zibuxostat, CA-1P and MPC-6827 and other phase I / II clinical trials reported cardiovascular adverse reactions such as hypertension, tachycardia, Bradyarrhythmia, atrial fibrillation, myocardial infarction, and dose-related adverse reactions limit its widespread clinical use

Method used

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  • Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion
  • Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion
  • Nano material and external radiation source-containing tumor treatment medicine for realizing tumor vascular occlusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1: AuSiO 2 Bubble generation experiment of aqueous solution under the action of laser

[0047] Such as image 3 As shown, AuSiO 2 Aqueous solution (concentration 25mg / mL) in 760nm laser pulse (average power 500mW, 16W / cm 2 ) under the action of a large number of bubbles, indicating that gold nanoparticles can generate heat under the action of laser pulses. 2 layer, does not perform rapid energy exchange with the outside world, and when the internal heat accumulates to a certain extent, an explosion occurs. The samples after laser treatment no longer produce explosive effects.

Embodiment 2

[0048] Example 2: AuSiO 2 Tumor treatment and effect verification of nanomaterials under the action of laser

[0049] 1. Establish the animal model of tumor-bearing mice:

[0050] Extract ascites from mice inoculated with H22 liver cancer cell line in the peritoneal cavity, centrifuge to remove the supernatant, and count the inoculated cells at a concentration of 10 7 50 μL of the cell suspension / mL was subcutaneously placed on the right thigh of each mouse. After 5-7 days of growth, the tumor size is about 5 mm for experiments.

[0051] 2. Animal experiment in vivo magnetic resonance imaging and tumor treatment experiment:

[0052] AuSiO injection via tail vein 2 200 μL of aqueous solution (concentration: 25 mg / mL, Au concentration: 10 mg / kg) was placed in tumor-bearing mice. A 760nm laser pulse was applied to the tumor site for 30 min, and images of tumor tissue, kidney and liver were collected at each time point.

[0053] Figure 4 It is a photo of the tumor after 24...

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Abstract

The invention discloses novel application of a nano material. The novel application is in the preparation of tumor vascular occlusion agent. The nano material has the following properties: (1) surface hydrophilicity is provided; (2) surface electronegativity is provided; (3) the nano material with size between 50-250nm and rigidity can not easily pass the holes on tumor blood vessels and can be stuck in the holes; and (4) the material is able to absorb external radiation energy, internally transforms the energy into heat, and accumulates the heat, so that the morphology and structure of the nano material drastically change. During the treatment, the nano material is injected into tumor-bearing bodies, and then radiation is applied to the tumor site, so that the nano material absorbs radiation energy and the internal temperature rises rapidly; when the temperature is accumulated to a certain extent, the morphology and structure of the nano material change (explosion or rapid expansion of volume), resulting in change of morphological structure or function of tumor vascular endothelial cells, and destruction of the tumor blood vessels.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a drug for treating tumors which is composed of nanometer materials and an external radiation source to block tumor blood vessels. Background technique [0002] In recent years, the morbidity and mortality of cancer have been on the rise. There are as many as 15 million new cancer patients in the world every year, which seriously threatens human health. The three traditional tumor treatment methods, namely surgery, radiotherapy and chemotherapy, all aim to kill tumor cells. However, with the advancement of cancer research, people gradually realized that there are not only tumor cells in tumor tissue, but also abundant tumor neovascularization, and tumor tissue is actually a complete ecosystem formed by tumor cells and tumor neovascularization. If a tumor grows rapidly, it must rely on the formation of new tumor blood vessels, and tumor blood vessels are the main metastasis ch...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/14A61K45/00A61P35/00
Inventor 王春儒甄明明王太山舒春英张国强邹头君
Owner 赤峰福纳康生物技术有限公司
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