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Preparation method and new application of lupulus natural pharmaceutical composition

A technology of natural medicine and hops, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problem of large side effects and achieve the effect of clear ingredients

Inactive Publication Date: 2014-12-10
JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main chemical lipase inhibitor is orlistat, but long-term use has serious side effects

Method used

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  • Preparation method and new application of lupulus natural pharmaceutical composition
  • Preparation method and new application of lupulus natural pharmaceutical composition
  • Preparation method and new application of lupulus natural pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0047] Example 1 Process for the preparation of hop compositions

[0048] Hops are extracted twice at 60°C with 8 times the amount of 85% ethanol, each time for 2 hours, filtered, combined filtrates, directly passed through the treated AB-8 macroporous adsorption resin, and first eluted with 85% ethanol for 3 times column volume, collect the effluent and ethanol eluate, and set aside; after elution with 95% ethanol for 4 times the column volume, collect the ethanol eluate, recover ethanol, concentrate to a thick paste, and freeze-dry to obtain component I; Ethanol was recovered from the effluent and ethanol eluent, concentrated until the content of ethanol in the concentrated solution was 25%, and passed through the treated polyamide adsorption resin again, first eluted with 25% ethanol for 4 times the column volume, and then 70% ethanol The eluate was 4 times the column volume, the ethanol eluate was collected, the ethanol was recovered, concentrated, and freeze-dried to ...

example 2

[0049] Example 2 Process for the preparation of hop compositions

[0050] Hops are extracted twice with 10 times the amount of 75% ethanol at 60°C, each time for 2 hours, filtered, combined with the filtrate, directly passed through the treated AB-8 macroporous adsorption resin, and first eluted with 75% ethanol for 3 times column volume, collect the effluent and ethanol eluate, and set aside; after elution with 95% ethanol for 3 times the column volume, collect the ethanol eluate, recover ethanol, concentrate to a thick paste, and freeze-dry to obtain component I; Ethanol was recovered from the effluent and ethanol eluent, concentrated until the content of ethanol in the concentrated solution was 20%, and passed through the treated polyamide adsorption resin again, first eluted with 20% ethanol for 4 times the column volume, and then 65% ethanol The eluate was 4 times the column volume, the ethanol eluate was collected, the ethanol was recovered, concentrated, and freeze-...

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Abstract

The invention discloses a composition which is extracted from moraceae lupulus and takes xanthohumol, isoxanthohumol, 8-isopentenyl naringenin, 6-isopentenyl naringenin, alpha-acid and beta-acid as main ingredients. An in-vivo experiment initially proves that the composition disclosed by the invention has activity of inhibiting lipase, so that the composition disclosed by the invention has new application in preparation of a medicine with a lipase inhibiting effect.

Description

Technical field [0001] The present invention involves the preparation method andNew use, specifically, is mainly containing a natural drugs for beer flowers of lobelinol, heteropathol, 8-isoprene base grapemine, 6-isoprene base grapemine, α-acid and β-acid.The composition has the effect of inhibiting lipase, and the present invention belongs to the field of pharmaceutical technology. Background technique [0002] At present, the sources of lipase inhibitors are chemical synthesis, natural plant extract, and microbial metabolites.Gargonuri et al. (1997) found that chemical synthetic organic phosphorus compounds have a significant inhibitory effect on lipase, but such lipase inhibitors are mainly used to study lipase catalytic reactions.Lipidase inhibitors are lipid -degraded weight loss pills specifically used to deal with lipase.Under the action of lipase inhibitors, the lipase will lose the ability to decompose part, so about one -third of the fat is not broken down by lipase, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P3/06A61P3/04A61K31/12A61K31/352
Inventor 赵全成南敏伦吕娜赵昱玮赫玉芳马吉胜王莲萍
Owner JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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