A kind of synthetic method of morpholine compound

A synthesis method and compound technology, which are applied in the field of synthesis of morpholine compounds, can solve problems such as poor environmental protection, and achieve the effects of low cost, mild reaction conditions, and simple and convenient operation
CN104193695BActive Publication Date: 2016-06-22HARBIN INST OF TECH
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN INST OF TECH
Publication Date
2016-06-22

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a synthesis method of morpholine compounds, belonging to the field of organic synthesis. The invention aims to solve the problem of poor environment friendliness of the traditional synthesis method of morpholine compounds. The method comprises the steps of firstly, adding heterocyclic nitrogen compounds, persulfate and 2-chlorohydrin into a reaction vessel, and reacting at room temperature; secondly, adding a diluent, then, adding KOH, carrying out cyclization reaction at room temperature, next, filtering, and concentrating to be dry to obtain a solid; and thirdly, carrying out silica gel column chromatographic purification and separation on the solid obtained in the second step by taking a mixed solution composed of petroleum ether and ethyl acetate as an eluant to obtain the morpholine compounds. The synthesis method is capable of realizing reaction at normal temperature and normal temperature, mild in reaction condition, free of inert gas protection and simple in operation; and the persulfate serving as an oxidizing agent is cheap, easy to obtain, free of pollution, safe, environment-friendly and low in cost.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of organic synthesis, in particular to a method for synthesizing morpholine compounds. Background technique

[0002] Morpholine is a series of nitrogen-containing heterocyclic compounds that widely exist in nature. Because of its excellent biological and pharmacological properties, morpholine is an important class of organic compounds in organic synthesis. In particular, N- and (or) 2-substituted morpholines have broad-spectrum biological activities and are an important class of candidate new drugs. In addition to its pharmacological utility, morpholines are frequently used as bases, N-alkylating reagents, catalysts, and chiral auxiliaries in a wide variety of organic transformations. Therefore, the research on the synthesis method of morpholine has attracted the attention of more and more scholars.

[0003] At present, there are many reports on the synthesis of morpholines from amino acids, aminoalcohols, epoxy com...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More