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Virginiamycin soluble powder and preparation method thereof

A virginiamycin, soluble technology, applied in the field of virginiamycin soluble powder and its preparation, can solve the problems of low bioavailability, limited popularization and application, uneven drug mixing, etc. Low ratio, strong operability, and the effect of overcoming uneven mixing

Active Publication Date: 2014-12-17
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, since virginiamycin is very slightly soluble in water, it can only be administered by making a premix and adding it to the feed. This method of administration often has uneven drug mixing and poor bioavailability. Low defects limit its application in the market

Method used

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  • Virginiamycin soluble powder and preparation method thereof
  • Virginiamycin soluble powder and preparation method thereof
  • Virginiamycin soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of virginiamycin soluble powder, the quality of each component is:

[0033] PEG-4000 10.0g, PEG-6000 40.0g, virginiamycin 10.0g, K30 5.0g, K12 1.0g, Fumei powder 5.0g, anhydrous glucose 29.0g.

[0034] Its preparation method is:

[0035] a) Weigh 10.0g of PEG-4000 and 40.0g of PEG-6000, mix evenly, and heat to 65°C to completely melt;

[0036] b) Weigh 5.0g of K30, 1.0g of K12, and 5.0g of Fumei powder, mix them evenly, pass through an 80-mesh sieve after grinding, add 10.0g of virginiamycin drug, mix evenly, and quickly add it to a) In the melt, stir quickly and evenly;

[0037] c) Pour the product obtained in step b) onto a flat plate, and cool at -20°C for 4 hours;

[0038] d) Take out the drug obtained in c), dry at 37°C, pulverize, and pass through an 80-mesh sieve to obtain a semi-finished product;

[0039] e) Add 29.0g of anhydrous glucose to the semi-finished product, mix evenly, and obtain 10% virginiamycin soluble powder after packaging.

Embodiment 2

[0041] A kind of virginiamycin soluble powder, the quality of each component is:

[0042] PEG-4000 30.0g, virginiamycin 0.01g, K30 2.0g, K12 0.5g, Fumei powder 5.0g, anhydrous glucose 62.49g.

[0043] Its preparation method is with embodiment 1.

Embodiment 3

[0045] A kind of virginiamycin soluble powder, the quality of each component is:

[0046] PEG-4000 30.0g, PEG-6000 40.0g, virginiamycin 20.0g, K30 3.0g, K12 2.0g, Fumei powder 2.0g, anhydrous glucose 3.0g.

[0047] Its preparation method is with embodiment 1.

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Abstract

The invention relates to virginiamycin soluble powder and a preparation method thereof, belonging to the technical field of medicines. The soluble powder is prepared from the following components in parts by weight: 0.01-20 parts of virginiamycin, 30-70 parts of polyethylene glycol-4000 and / or polyethylene glycol-6000, 1-10 parts of povidone K30, 0.5-2 parts of lauryl sodium sulfate and 1-10 parts of Fumei powder. The soluble powder provided by the invention is good in water solubility and uniform to dissolve, medicines are not separated out, and a water line is not blocked. Compared with the conventional manner of delivery by feed, the soluble powder is more convenient to use and provides a novel virginiamycin medication manner for the market. In addition, the medicine provided by the invention is good in stability and strong in operability of production processes, thereby facilitating market promotion.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a virginiamycin soluble powder and a preparation method thereof. Background technique [0002] Virginmycin is a polypeptide antibiotic isolated from bacteria of the genus Streptomyces when Professor Dai Soma of the University of Lubang in Belgium conducted a screening test on soil. Its mechanism of action is to inhibit the ribosomes of Gram-positive bacteria to prevent bacterial protein synthesis and achieve bactericidal purposes. When the drug enters the intestinal tract of animals, it selectively kills intestinal bacteria, kills harmful bacteria and retains probiotics, reduces the consumption of nutrients by bacteria, reduces the production of harmful substances, slows down intestinal peristalsis, and feed stays in the intestinal tract The longer the time, the more complete the absorption of nutrients, thereby promoting the growth of animals. [0003] The ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/14A61K47/34A61P31/04
Inventor 李会芳郭建军曹伟伟张法学
Owner HENAN SOAR VETERINARY PHARMA
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