Composition, use and health care product

Abstract

The invention relates to the technical field of biology and particularly relates to a composition, application thereof and a health product. The effect of the composition for treating acute gastric mucosa injury is remarkably improved; and clinical tests prove that the symptom of gastric discomfort caused by gastric mucosa injury can be effectively relieved in the process of taking a gastric mucosa protecting tablet. The composition and the health product are proven to have advantages on the aspects of protecting and repairing gastric mucosa and be beneficial to promotion of ulcer healing and relief of symptoms of patients.

Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a composition, application and health care product. Background technique

[0002] Gastric mucosal injury is the main pathophysiological link leading to active chronic gastritis with gastric ulcer. At present, it is believed that the occurrence of its damage is relatively weakened after the weakening of the protective effect of gastric mucosa, that is, it is closely related to the imbalance of aggressive factors and protective / defensive factors of gastric mucosa.

[0003] Gastric mucosal damage is often caused by chemical factors (smoking, drinking, strong tea, coffee, and drugs that irritate the gastric mucosa such as aspirin, indomethacin, etc.), physical factors (too cold, too hot, too rough food or overeating) etc.), bacteria or their toxin stimulation and other factors. No matter what kind of invasive factors, the gastric mucosal injury caused by it shows a programmed injury re...

Examples

Embodiment 1

[0038] Embodiment 1 Animal test

[0039] Dose protection of main raw materials:

[0040]

[0041]

[0042] Effects on alcohol-induced acute gastric mucosal injury rat model:

[0043] Select SPF grade SD rats, male, weighing 180-220g. Every batch of animals is randomly divided into 8 groups by body weight, including normal control group, model control group, single drug group and test group (table 1), every group of 10, each group is all by oral gavage of 10ml / kg, 1 times / day. Rats were fasted without food and water for 24 hours before modeling. Except for the normal control group, all other groups were administered once to create models of acute gastric mucosal injury. In order to observe the cumulative effect of the drug effect, another 80 rats were administered in the same way at 9 am every day for 7 days. On the 6th day, the rats were fasted for 24 hours. At 9 a.m. on the 7th day, the model was established 1 hour after administration. One hour after modeling, the...

Embodiment 2

[0054] The preparation of embodiment 2 tablet

[0055]

[0056]

[0057] Weigh Hericium erinaceus or Hericium erinaceus extract, chitosan, wheat oligopeptide, microcrystalline cellulose, mannitol, crospovidone, magnesium stearate, silicon dioxide in the formula A certain amount of raw and auxiliary materials are put into the mixer and mixed for 20-30 minutes.

[0058] The above mixture is compressed into tablets with a tablet machine, 1 g / tablet, to obtain plain tablets.

[0059] Weigh the coating agent according to the formula, adjust it to a suitable solid content, and stir it in a paddle pan for 30 to 45 minutes; after the stirring is completed, coat the plain tablet until the surface of the tablet is basically formed into a film and the color is consistent.

Embodiment 3

[0060] The preparation of embodiment 3 tablet

[0061]

[0062]

[0063] Weigh Hericium erinaceus or Hericium erinaceus extract, chitosan, wheat oligopeptide, microcrystalline cellulose, mannitol, crospovidone, magnesium stearate, silicon dioxide in the formula A certain amount of raw and auxiliary materials are put into the mixer and mixed for 20-30 minutes.

[0064] The above mixture is compressed into tablets with a tablet machine, 1 g / tablet, to obtain plain tablets.

[0065] Weigh the coating agent according to the formula, adjust it to a suitable solid content, and stir it in a paddle pan for 30 to 45 minutes; after the stirring is completed, coat the plain tablet until the surface of the tablet is basically formed into a film and the color is consistent.

technical field

[0001] The invention relates to the field of biotechnology, in particular to a composition, application and health care product. Background technique

[0002] Gastric mucosal injury is the main pathophysiological link leading to active chronic gastritis with gastric ulcer. At present, it is believed that the occurrence of its damage is relatively weakened after the weakening of the protective effect of gastric mucosa, that is, it is closely related to the imbalance of aggressive factors and protective / defensive factors of gastric mucosa.

[0003] Gastric mucosal damage is often caused by chemical factors (smoking, drinking, strong tea, coffee, and drugs that irritate the gastric mucosa such as aspirin, indomethacin, etc.), physical factors (too cold, too hot, too rough food or overeating) etc.), bacteria or their toxin stimulation and other factors. No matter what kind of invasive factors, the gastric mucosal injury caused by it shows a programmed injury re...

Examples

Embodiment 1

[0038] Embodiment 1 Animal test

[0039] Dose protection of main raw materials:

[0040]

[0041]

[0042] Effects on alcohol-induced acute gastric mucosal injury rat model:

[0043] Select SPF grade SD rats, male, weighing 180-220g. Every batch of animals is randomly divided into 8 groups by body weight, including normal control group, model control group, single drug group and test group (table 1), every group of 10, each group is all by oral gavage of 10ml / kg, 1 times / day. Rats were fasted without food and water for 24 hours before modeling. Except for the normal control group, all other groups were administered once to create models of acute gastric mucosal injury. In order to observe the cumulative effect of the drug effect, another 80 rats were administered in the same way at 9 am every day for 7 days. On the 6th day, the rats were fasted for 24 hours. At 9 a.m. on the 7th day, the model was established 1 hour after administration. One hour after modeling, the...

Embodiment 2

[0054] The preparation of embodiment 2 tablet

[0055]

[0056]

[0057] Weigh Hericium erinaceus or Hericium erinaceus extract, chitosan, wheat oligopeptide, microcrystalline cellulose, mannitol, crospovidone, magnesium stearate, silicon dioxide in the formula A certain amount of raw and auxiliary materials are put into the mixer and mixed for 20-30 minutes.

[0058] The above mixture is compressed into tablets with a tablet machine, 1 g / tablet, to obtain plain tablets.

[0059] Weigh the coating agent according to the formula, adjust it to a suitable solid content, and stir it in a paddle pan for 30 to 45 minutes; after the stirring is completed, coat the plain tablet until the surface of the tablet is basically formed into a film and the color is consistent.

Embodiment 3

[0060] The preparation of embodiment 3 tablet

[0061]

[0062]

[0063] Weigh Hericium erinaceus or Hericium erinaceus extract, chitosan, wheat oligopeptide, microcrystalline cellulose, mannitol, crospovidone, magnesium stearate, silicon dioxide in the formula A certain amount of raw and auxiliary materials are put into the mixer and mixed for 20-30 minutes.

[0064] The above mixture is compressed into tablets with a tablet machine, 1 g / tablet, to obtain plain tablets.

[0065] Weigh the coating agent according to the formula, adjust it to a suitable solid content, and stir it in a paddle pan for 30 to 45 minutes; after the stirring is completed, coat the plain tablet until the surface of the tablet is basically formed into a film and the color is consistent.

Images