L-ornithine lipoic acid compound salt, and preparation method and application thereof

A technology of ornithine sulfur and compound salt is applied in the field of medicine and achieves the effects of low cost, high purity and simple and easy preparation method

Active Publication Date: 2015-03-04
NANJING UNIV OF TECH
View PDF8 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report that L-ornithine and lipoic acid are made i

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • L-ornithine lipoic acid compound salt, and preparation method and application thereof
  • L-ornithine lipoic acid compound salt, and preparation method and application thereof
  • L-ornithine lipoic acid compound salt, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: Preparation of L-ornithine lipoic acid compound salt

[0046] Step 1: Preparation of free L-ornithine

example 1

[0048] Dissolve 30g of L-ornithine hydrochloride in 1L of water, adjust its pH to 2.0 with hydrochloric acid, then flow the adjusted pH-adjusted L-ornithine hydrochloride solution through the filling chamber at a flow rate of 6ml / min The ion-exchange column of JK006 cation exchange resin, and then rinse the column with deionized water to wash away the chloride ions between the resins, and finally use 0.8mol / L ammonia water to flow through the column at a flow rate of 8ml / min to release the free L-ornithine Eluted from the resin, free L-ornithine aqueous solution was obtained.

example 2

[0050] According to the method disclosed in the patent document CN101955901, a fermented liquid containing L-ornithine is obtained, and after the fermented liquid is treated by removing bacteria and pigment, an aqueous solution containing free L-ornithine is obtained.

[0051] Step 2: preparing L-ornithine lipoic acid compound salt;

[0052] example 1:

[0053] Concentrate the free L-ornithine aqueous solution in Step 1 Example 1, and the concentration of free L-ornithine in the obtained concentrated solution is 54.7wt%. Dissolve 20g of lipoic acid in 400ml of absolute ethanol, add 22.5g of the above-mentioned free L-ornithine concentrate to it, and stir at a constant temperature of 20°C for 120min to complete the reaction and obtain an ethanol-insoluble precipitate, which is filtered to remove the solid-liquid mixture Ethanol, put the filtered solid into a blast drying oven, and dry at 40° C. for 6 to 8 hours to obtain 28.98 grams of light yellow solid powder. The above yel...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of pharmaceutical chemical engineering, and discloses a L-ornithine lipoic acid compound salt, and a preparation method and application thereof. A structural formula of the L-ornithine lipoic acid compound salt is as shown in the formula I. The L-ornithine lipoic acid compound salt has functions of preventing and treating hepatic coma caused by acute and chronic hepatic diseases such as liver cirrhosis, fatty liver, hepatitis and the like and can be used for preparing a medicament for treating hepatic coma. The preparation method for the L-ornithine lipoic acid compound salt is simple and easy to operate and is low in cost; the product is high in purity.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to L-ornithine lipoic acid compound salt and its preparation method and application. Background technique [0002] Lipoic acid is a biological antioxidant that can scavenge oxygen free radicals in the body, regenerate other antioxidants, chelate transition metals, and repair oxidation-damaged proteins. Moreover, lipoic acid is the only known fat-soluble and water-soluble antioxidant that can function anywhere in the body's cells. In the field of medicine, lipoic acid can be used to treat various liver diseases, such as alcoholic liver injury, acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, etc. However, lipoic acid itself has some defects, such as low water solubility and instability under certain conditions, which are not conducive to the use and storage of lipoic acid. Nowadays, many effective methods have been proposed to improve the physicochemical properties of lipoic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D339/04A61K31/385A61P1/16
CPCC07D339/04
Inventor 万红贵龚寅聪石楠万淼
Owner NANJING UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap