L-ornithine lipoic acid compound salt and its preparation method and application

Abstract

The invention belongs to the field of pharmaceutical chemical engineering, and discloses a L-ornithine lipoic acid compound salt, and a preparation method and application thereof. A structural formula of the L-ornithine lipoic acid compound salt is as shown in the formula I. The L-ornithine lipoic acid compound salt has functions of preventing and treating hepatic coma caused by acute and chronic hepatic diseases such as liver cirrhosis, fatty liver, hepatitis and the like and can be used for preparing a medicament for treating hepatic coma. The preparation method for the L-ornithine lipoic acid compound salt is simple and easy to operate and is low in cost; the product is high in purity.

Description

technical field

[0001] The invention belongs to the field of medicine, and relates to L-ornithine lipoic acid compound salt and its preparation method and application. Background technique

[0002] Lipoic acid is a biological antioxidant that can scavenge oxygen free radicals in the body, regenerate other antioxidants, chelate transition metals, and repair oxidation-damaged proteins. Moreover, lipoic acid is the only known fat-soluble and water-soluble antioxidant that can function anywhere in the body's cells. In the field of medicine, lipoic acid can be used to treat various liver diseases, such as alcoholic liver injury, acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, etc. However, lipoic acid itself has some defects, such as low water solubility and instability under certain conditions, which are not conducive to the use and storage of lipoic acid. Nowadays, many effective methods have been proposed to improve the physicochemical properties of lipoic...

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