The invention discloses an ambroxol hydrochloride osmotic pump controlled-release tablet, which belongs to the field of preparation of ambroxol hydrochloride osmotic pump controlled-release tablets. The ambroxol hydrochloride osmotic pump controlled-release tablet of the present invention comprises a tablet core composed of a drug-containing layer and a booster layer, the tablet core is covered with a semipermeable film coat, and one or more small drug release holes are arranged on the surface of the semipermeable film coat , pack moisture-proof clothing; Described drug-containing layer is made up of ambroxol hydrochloride, suspending agent, penetrating agent, osmotic pressure active substance, binding agent, colorant and lubricant; Described booster layer is made up of penetrating agent, It is composed of polymer swelling material, osmotic pressure active substance, coloring agent, adhesive and lubricant; the semipermeable film coating is composed of film material, plasticizer, porogen and solvent. The ambroxol hydrochloride osmotic pump controlled-release tablet of the present invention has the advantages of convenient administration, long-lasting effect, release at an approximately constant rate for 0-12 hours, maintains stable blood drug concentration, reduces toxic and side effects, reduces the number of times of taking medicine and has a suitable tablet Weight, enhance patient compliance and other advantages.