Novel therapeutic treatments with anti-HER2 antibodies having low fucosylation
A fucose, fucose amount technology, applied in the direction of antibody medical ingredients, antibodies, chemical instruments and methods, can solve problems such as death, and achieve the effect of high therapeutic efficacy
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment approach
[0453] Specific and particularly preferred embodiments of the invention will be described below:
[0454]In a first specific embodiment, the present invention relates to a fucose-reduced anti-HER2 antibody for use in the treatment of a patient with a HER2-positive cancer, wherein the HER2-positive cancer has HER2 of degree 2+ or less, preferably of degree 1+ Anti-HER2 antibodies overexpressed, as determined by immunohistochemistry (IHC), and wherein preferably the cancer is metastatic cancer, wherein fucose is reduced
[0455] (i) having fucose in an amount of 20% or less, preferably 15% or less, more preferably 10% to 0% or 10% to 3%, halved in an amount of at least 8% in the CH2 domain type GlcNAc and galactose in an amount of at least 65%;
[0456] (ii) comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 7 or an amino acid sequence at least 80% identical thereto, wherein CDR1 has the amino acid sequence of SEQ ID NO: 1, CDR2 has the a...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More