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Anti-tumor effect enhancer and anti-tumor preparation

An anti-tumor agent and anti-tumor technology, applied in the direction of anti-tumor drugs, active ingredients of heterocyclic compounds, drug combinations, etc., to achieve a strong anti-tumor enhancement effect

Inactive Publication Date: 2015-03-25
朱忠良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the antitumor effect of the combination therapy of liposome preparation and combination drug needs to be further improved.

Method used

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  • Anti-tumor effect enhancer and anti-tumor preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] DPPC (L-α-dipalmitoylphosphatidylcholine, CoatsomeMC-6060, manufactured by NOF Corporation), cholesterol (special grade, manufactured by Wako Pure Chemical Industries, Ltd.) and mPEG2000-DSPE (1, 2-distearoyl-sn-glycerol-3-phosphoethanolamine-n-[methoxy (polyethylene glycol)-2000], SunbrightDSPE-020CN, manufactured by NOF Company) was dissolved in chloroform to obtain 20mM, 50mM respectively and a concentration of 5mM. Subsequently, 5 ml of 20 mM DPPC solution, 0.5 ml of 50 mM cholesterol solution, and 1 ml of 5 mM mPEG2000-DSPE solution were placed in a pear-shaped bottle. While depressurizing using an evaporator, remove chloroform to form a lipid film at the bottom of the pear-shaped flask. The lipid film was dissolved with 6ml of chloroform / diethyl ether (volume ratio 1:2). Lomustine was dissolved in a 5% glucose solution so that the concentration of lomustine became 8 mg / ml. The lomustine solution (2 ml) thus prepared was added to the lipid solution, followed by ...

Embodiment 2

[0088]HSPC (hydrogenated soybean phosphatidylcholine, CoatsomeNC-21, manufactured by NOF Corporation), cholesterol (special grade, manufactured by Wako Pure Chemical Industries, Ltd.) and mPEG2000-DSPE (1,2-dihard Fatty acyl-sn-glycerol-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000], Sunbright DSPE-020CN, manufactured by NOF Company) was dissolved in chloroform to obtain concentrations of 20 mM, 50 mM and 5 mM, respectively . Subsequently, 5 ml of 20 mM HSPC solution, 1 ml of 50 mM cholesterol solution, and 2 ml of 5 mM mPEG2000-DSPE solution were placed in a pear-shaped bottle. While depressurizing using an evaporator, chloroform was removed to form a lipid film at the bottom of the pear-shaped flask. The lipid film was dissolved with 6ml of chloroform / diethyl ether (volume ratio 1:2). Lomustine was dissolved in a 5% glucose solution so that the concentration of lomustine became 8 mg / ml. The lomustine solution (2 ml) thus prepared was added to the lipid soluti...

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Abstract

The invention relates to an anti-tumor effect enhancer and an anti-tumor preparation. The anti-tumor effect enhancer is a lipidosome preparation containing an effective dose of lumostine, and can be used for improving the anti-tumor activity of a combined medicine containing effective doses of tegafur, gimeracil and oteracil potassium. Compared with the prior art, the anti-tumor effect enhancer has the advantage of stronger anti-tumor enhancing effect for the combined medicine containing tegafur, gimeracil and oteracil potassium.

Description

technical field [0001] The invention relates to the technical field of anti-tumor drugs, in particular to an anti-tumor effect enhancer containing lomustine liposome preparation, and an anti-tumor agent containing the liposome preparation. Background technique [0002] So far, many anticancer agents have been developed and used in the medical field. For example, tegafur is activated in vivo and gradually releases the active form, ie, 5-fluorouracil (hereinafter referred to as "5-FU"), thus alleviating the toxicity or side effects exhibited by 5-FU. A combination drug containing tegafur, gimeracil, and oteracil potassium (trade name: TS-1, the molar ratio of tegafur / gimeracil / oxonate potassium =1:0.4:1, manufactured by Taiho Pharmaceutical Co., Ltd., hereinafter the combination drug is referred to as TS-1) has a stronger antitumor effect because gimerast inhibits 5 - Degradation of FU. In this formulation, the therapeutic effect is improved because oxonate potassium specif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/53A61K31/513A61K31/4412A61K31/44A61K9/127A61P35/00A61K31/175
Inventor 朱忠良
Owner 朱忠良
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