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Mulberry resource long-acting hypoglycemic medicine composition as well as granules and preparation method thereof

A technology for hypoglycemic and composition, applied in the field of long-acting hypoglycemic pharmaceutical composition of mulberry resources and its granules and preparation, can solve the problem of short half-life and the like, achieve prolonging time, delaying release and absorption, long-acting postprandial blood sugar horizontal effect

Inactive Publication Date: 2015-04-01
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such natural products have a short half-life in the body and will disappear within 1.5-2 hours

Method used

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  • Mulberry resource long-acting hypoglycemic medicine composition as well as granules and preparation method thereof
  • Mulberry resource long-acting hypoglycemic medicine composition as well as granules and preparation method thereof
  • Mulberry resource long-acting hypoglycemic medicine composition as well as granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Use a pulverizer to crush the selected and dried mulberry leaves, mulberry branches, mulberry bark, mulberry and kudzu root, and pass through a 60-mesh sieve.

[0026] 2. Weigh 1.5 kg of crushed and sieved mulberry leaves, mulberry branches, Morus alba and mulberry mixed powder, add 7.5 L 70% ethanol solution, extract at room temperature for 2 h, filter to remove residue; add 7.5 L 70% ethanol solution for the second and third times Ethanol solution, extract at room temperature for 1 h, filter, and combine the filtrates for 3 times; the filtrate is absorbed by D061 cation exchange resin, the effluent is collected, concentrated and freeze-dried to obtain the flavonoid extract of mulberry resources; the D061 cation exchange resin is washed with sufficient distilled water After removing impurities, use 3 times of 0.8 mol / L ammonia solution to elute, concentrate the eluent to the extract, and freeze-dry to obtain the alkaloid extract of mulberry resources; boil the residu...

Embodiment 2

[0030] Example 2 is the same as Example 1 except that 1 g of the hypoglycemic active extract of mulberry resources is mixed with 0.33 g of Pueraria flavonoids extract.

Embodiment 3

[0032] Example 3 is the same as Example 1 except that 1 g of the hypoglycemic active extract of mulberry resources is mixed with 1 g of Pueraria flavonoids extract.

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Abstract

The invention discloses a mulberry resource long-acting hypoglycemic medicine composition as well as granules and a preparation method thereof. The mulberry resource long-acting hypoglycemic medicine composition comprises a mulberry resource hypoglycemic activity extract, a pueraria root flavonoid extract, gelatin and microbial transglutaminase; and the preparation method of the mulberry resource long-acting hypoglycemic granules comprises the following steps: preparing the mulberry resource hypoglycemic activity extract, preparing the pueraria root flavonoid extract, preparing the hypoglycemic granules, and the like. The mulberry resource hypoglycemic medicine composition and the granules prepared by using the method disclosed by the invention can be used for controlling the level of postprandial blood sugar in multi-way and long-acting modes.

Description

technical field [0001] The invention relates to the technical field of hypoglycemic drugs, in particular to a mulberry resource long-acting hypoglycemic drug composition, granules and a preparation method thereof. Background technique [0002] Diabetes (Diabetes) is a common chronic non-communicable disease, and its harm is huge, which is called the disaster of the 21st century by the World Health Organization. At present, the main clinical treatment method is to use hypoglycemic western medicine to control the blood sugar level in plasma, which treats the symptoms but not the root cause, which will lead to drug resistance in diabetic patients and cause various toxic side effects such as hypoglycemia. Therefore, it is of great significance to find high-efficiency and low-toxicity hypoglycemic natural products and use them to develop hypoglycemic products. [0003] mulberry( Morus alba L. )'s medicinal value has been included in many medical classics such as "Shen Nong's Ma...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61K9/16A61P3/10
CPCA61K36/605A61K9/1658A61K9/1664A61K2236/331A61K2236/333A61K2236/55
Inventor 王元成徐立
Owner SOUTHWEST UNIVERSITY
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