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Duck viral hepatitis and duck plague bigeminal egg yolk antibody oral solution and preparation method thereof

A duck viral hepatitis, oral liquid technology, applied in the direction of antibodies, antiviral agents, resistance to vector-borne diseases, etc., can solve the problem of inconvenient use of duck plague double yolk antibody, and improve immunity and stress ability. , the biological activity is not affected, the effect of high bioavailability

Inactive Publication Date: 2015-04-08
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides an oral solution of duck viral hepatitis and duck plague dual-linked yolk antibody and a preparation method thereof, which solves the problem of inconvenient use of duck viral hepatitis and duck plague dual-linked yolk antibody for injection

Method used

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  • Duck viral hepatitis and duck plague bigeminal egg yolk antibody oral solution and preparation method thereof
  • Duck viral hepatitis and duck plague bigeminal egg yolk antibody oral solution and preparation method thereof
  • Duck viral hepatitis and duck plague bigeminal egg yolk antibody oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A formula for duck viral hepatitis and duck plague dual-linked egg yolk antibody oral solution includes the following raw materials: 105 L of whole egg aqueous solution containing egg yolk antibody, 0.2 L of caprylic acid, 0.3 L of formaldehyde, 0.02 L of thimerosal, and 1000 units / ml oral solution penicillin streptomycin.

[0020] Its preparation method comprises the following steps:

[0021] 1) Use commercially available duck viral hepatitis and duck plague dual inactivated vaccines for enhanced immunization. The dosage of each vaccine for each chicken is 2ml, and the immunization procedures are carried out three times at intervals of 10 days. When the antibody titer reaches 1: At 256 hours, start collecting high immunity eggs.

[0022] 2) Sort the collected high-free eggs, sterilize with 0.2% bromogeramine, and set aside.

[0023] 3) Acidification treatment by water dilution method: Beat 2) Bugao egg-free whole eggs into the pasteurized tank for full emulsification...

Embodiment 2

[0042] A formula for duck viral hepatitis and duck plague dual yolk antibody oral solution includes the following raw materials: 95 L of whole egg aqueous solution containing yolk antibody, 0.2 L of caprylic acid, 0.2 L of formaldehyde, 0.01 L of thimerosal, and 800 units / ml oral solution penicillin streptomycin.

[0043] Its preparation method comprises the following steps:

[0044] 1) Use commercially available duck viral hepatitis and duck plague dual inactivated vaccines for enhanced immunization. The dosage of each vaccine is 2ml for each chicken, and the immunization procedures are carried out three times at intervals of 10 days. When the antibody titer reaches 1: At 128, start collecting high immunity eggs.

[0045] 2) Sort the collected high-free eggs, sterilize with 0.1% bromogeramine, and set aside.

[0046] 3) Acidification treatment by water dilution method: Beat 2) Bugao egg-free whole eggs into the pasteurized tank for full emulsification, emulsification time is ...

Embodiment 3

[0065] A formula for duck viral hepatitis and duck plague dual-linked egg yolk antibody oral solution includes the following raw materials: 100 L of whole egg aqueous solution containing egg yolk antibody, 0.3 L of caprylic acid, 0.3 L of formaldehyde, 0.02 L of thimerosal, and 1000 units / ml oral solution penicillin streptomycin.

[0066] Its preparation method comprises the following steps:

[0067] 1) Use commercially available duck viral hepatitis and duck plague dual inactivated vaccines for enhanced immunization. The dosage of each vaccine for each chicken is 2ml, and the immunization procedures are carried out three times at intervals of 10 days. When the antibody titer reaches 1: At 256 hours, start collecting high immunity eggs.

[0068] 2) Sort the collected high-free eggs, sterilize with 0.2% bromogeramine, and set aside.

[0069] 3) Acidification treatment by water dilution method: Beat 2) Bugao egg-free whole eggs into the pasteurized tank for full emulsification...

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Abstract

The invention discloses a duck viral hepatitis and duck plague bigeminal egg yolk antibody oral solution and a preparation method thereof. The formula is characterized in that the duck viral hepatitis and duck plague bigeminal egg yolk antibody oral solution comprises the following raw materials in percentage by volume: 95-105 of a whole-egg water solution containing an egg yolk antibody, 0.2-0.3 of octanoic acid, 0.2-0.3 of formaldehyde, 0.01-0.02 of merthiolate and 800-1000 units of mycillin in every milliliter of the oral solution. Whole eggs with high immunoglobulin are adopted during preparation, so that the clear egg yolk antibody oral solution is obtained. The egg yolk antibody oral solution prepared by using the preparation method is not only low in loss, high in immune active substance content, high in biological activity and free of clinical side effects in the production process, but also contains a great number of various proteins in egg white, so that the adverse effects on the antibody can be reduced during oral administration.

Description

technical field [0001] The invention belongs to the technical field of biological products for poultry, and relates to a duck viral hepatitis and duck plague dual yolk antibody oral liquid and a preparation method thereof. Background technique [0002] Duck viral hepatitis and duck plague are common diseases in the duck industry, which are prone to large-scale outbreaks. Sometimes the two will be mixed with infection, which increases the difficulty of treatment. There are many prevention and treatment methods, among which egg yolk antibody is the most effective method for treating viral diseases in ducks. [0003] Duck viral hepatitis is referred to as duck hepatitis for short. It mainly harms ducklings under 20 days old. The younger the ducklings are, the higher the mortality rate is. The highest mortality rate can reach 90%-95%, and all antibiotics are ineffective against this disease. my country discovered this disease in 1958, and this disease was prevalent again in our...

Claims

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Application Information

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IPC IPC(8): A61K39/42A61P31/14A61P31/20
CPCY02A50/30
Inventor 徐进李建正郭俊清
Owner ZHENGZHOU HOUYI PHARMA
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