Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia

A technology for acute myeloid, leukemia, applied in the field of treatment and management of cancer, diagnosis, diagnosis, prognosis and treatment of blood cancer, which can solve problems such as the difficulty of diagnosis and treatment to develop effective therapies

Inactive Publication Date: 2015-04-08
MEMORIAL SLOAN KETTERING CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, cancers vary widely in their genetic "signatures," leading to difficu

Method used

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  • Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia
  • Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia
  • Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia

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Embodiment

[0166] While the invention has been generally described, it may be better understood in conjunction with the following examples, which are intended to illustrate specific aspects of embodiments of the invention and are not intended to limit the invention in any way to illustrations implementation plan.

[0167] Each of the applications and patents cited herein, and each document or reference cited in each of said applications and patents (“Application Cited Documents”), and all and / or substantial portions of these applications and patents are claimed to Each of the PCT and foreign applications or patents to which priority is claimed, and each document cited or referenced in each of the cited documents of said application, is hereby expressly incorporated herein by reference. More generally, documents or references cited herein, whether in a reference list or in the text, and each document or reference cited in a reference cited herein (including any manufacturer's instructions...

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Abstract

Gene mutations are associated with the progression of acute myeloid leukemia (AML). The invention relates to methods and systems for evaluating the progression of AML based on these gene mutations. The present invention also relates to methods and compositions for treating AML patients by modulating the expression or activity of certain genes involved in AML progression and/or their encoded proteins. The invention further relates to methods and compositions for determining the responsiveness of an AML patient to induction chemotherapy therapy.

Description

[0001] Cross references to related patent applications [0002] This patent application claims priority to US Provisional Patent Application No. 61 / 609,723, filed March 12, 2012. Each prior application is hereby incorporated by reference in its entirety. [0003] sequence listing [0004] This application includes a Sequence Listing submitted in ASCII format via EFS-Web, which is hereby incorporated by reference into this application in its entirety. Said ASCII copy was created on March 7, 2013, is named 3314.002AWO_SL.txt, and is 75,356 bytes in size. [0005] Statement on Federal Funding for Research and Development [0006] This invention was made with Government support under Contract No. U54CA143798-01 awarded by the National Cancer Institute Center for Oncology Natural Sciences. The US Government has certain rights in this invention. technical field [0007] The present invention relates to methods for diagnosing, treating and managing cancer. The technical field o...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q2600/156A61K31/704C12Q1/6886C12Q2600/106C12Q2600/118A61P35/02
Inventor 罗斯·L·莱文奥马尔·阿卜杜勒-瓦希卜杰伊·P·帕特尔米特哈特·戈嫩
Owner MEMORIAL SLOAN KETTERING CANCER CENT
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