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A group of markers for predicting the curative effect of nasopharyngeal carcinoma induced chemotherapy, and applications thereof

A marker and nasopharyngeal carcinoma technology, applied in the field of biomarkers, can solve the problems of limited benefit, achieve the effect of accurately inducing chemotherapy efficacy and guiding clinical medication

Active Publication Date: 2020-04-21
SUN YAT SEN UNIV CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the short-term efficacy of patients after induction chemotherapy can predict their long-term survival outcomes, and SD patients play the role of "accompanying" in induction chemotherapy, with limited benefits

Method used

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  • A group of markers for predicting the curative effect of nasopharyngeal carcinoma induced chemotherapy, and applications thereof
  • A group of markers for predicting the curative effect of nasopharyngeal carcinoma induced chemotherapy, and applications thereof
  • A group of markers for predicting the curative effect of nasopharyngeal carcinoma induced chemotherapy, and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Discovery of Molecular Targets for Nasopharyngeal Carcinoma Induction Chemotherapy

[0031] The inventor used the NanoString nCounter technology platform to detect these 43 differentially expressed genes and 5 internal reference genes in 342 samples of the training group (from Sun Yat-sen University Cancer Prevention and Control Center), and screened out 6 genes most related to the efficacy of induction chemotherapy to construct a model. The inventor named this group of 6-gene markers as 6-gene signature, and its calculation formula is:

[0032] 6-Gene signature score = -26.01361+(0.36816×AL161418.1 expression)-(0.64682×LRRD1 expression)+(0.70213×OGFRL1 expression)+(0.07571×PLAC8 expression)+(0.24862×PTGS2 expression )+(1.54186×RNF138 expression level).

[0033] The ROC curve was used to generate a threshold value of -2.522, thus 243 patients (71.1%) were divided into the benefit group, and 99 patients (28.9%) were divided into the non-benefit group; AUC rea...

Embodiment 2

[0034] Example 2 Further verification of molecular targets for nasopharyngeal carcinoma induction chemotherapy efficacy

[0035] The inventors then verified this set of molecular labels in samples from this hospital and a set of samples from other hospitals.

[0036]Of 187 patients in our in-house validation cohort (from a Phase III clinical trial), the gene signature classified 130 (69.5%) patients into benefit and 57 (30.5%) into no benefit ; The AUC of this gene signature to predict the short-term curative effect of nasopharyngeal carcinoma induction chemotherapy reaches 0.82 (95% CI 0.68-0.94), the sensitivity is 87.5%, and the specificity is 71.8% (see appendix figure 1 ); in the benefit group, disease-free survival of patients receiving induction chemotherapy (HR 0.37, 0.18-0.75, P=0.0039; see appendix figure 2 ), overall survival (HR 0.37,0.17-0.85, p=0.014; see appendix image 3 ), distant metastasis-free survival (HR 0.41, 0.18-0.93, p=0.027; see appendix Figure ...

Embodiment 3

[0038] Example 3 Comparison of Molecular Targets for Nasopharyngeal Carcinoma Induction Chemotherapy Efficacy and Other Clinical Indicators Predictive Efficiency

[0039] The inventors compared the effectiveness of the above-mentioned gene signature with other clinical indicators (age, sex, TNM stage, EBV DNA) in predicting the efficacy of induction chemotherapy, and found that the gene signature was equally effective in the training group, internal verification group (clinical trial group) and external verification group. Showed better predictive performance (comparing the ROC of the gene model with other clinical indicators to predict curative effect, all p values ​​were Figure 5 ).

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Abstract

The invention discloses a group of markers for predicting the curative effect of nasopharyngeal carcinoma induced chemotherapy, and applications thereof, wherein the markers comprise AL161418.1, LRRD1, OGFRL1, PLAC8, PTGS2 and RNF138. The molecular label formed by the expression of the six genes can reflect the biological specificity of a nasopharyngeal carcinoma patient, can accurately predict the induced chemotherapy curative effect of the nasopharyngeal carcinoma patient, and can well guide clinical medication.

Description

technical field [0001] The present invention relates to the technical field of biomarkers, more specifically, to a group of markers for predicting the curative effect of nasopharyngeal carcinoma induction chemotherapy and its application. Background technique [0002] The incidence of nasopharyngeal carcinoma is high in China, accounting for 47% of the world's cases, which seriously endangers the life and health of our people. Radiation therapy is the main treatment for nasopharyngeal carcinoma, but more than 70% of patients are already in the middle and late stage when they see a doctor, and they need to receive comprehensive treatment of radiotherapy combined with chemotherapy. [0003] A multi-center phase III randomized controlled clinical trial involving 480 cases of locoregionally advanced nasopharyngeal carcinoma (stage II-IVb) conducted by the research team of the inventor found that the three drugs of docetaxel + cisplatin + fluorouracil (TPF) Induction chemotherap...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12Q1/6851G01N33/574
CPCC12Q1/6886C12Q1/6851G01N33/57407C12Q2600/158C12Q2600/106G01N2800/52C12Q2545/101C12Q2537/165
Inventor 马骏孙颖柳娜黎映琴唐玲珑雷媛洪晓鸿张媛陈磊李文菲毛燕萍刘需陈雨沛
Owner SUN YAT SEN UNIV CANCER CENT
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