vitamin d 2 Glycoside analogs, synthesis and application

Abstract

The invention discloses a vitamin D2 glucoside analogue, a synthesis and an application thereof. According to the invention, vitamin D2 is taken as a raw material, vitamin D2 fragment alcohol is prepared through an oxidation reduction reaction, and then vitamin D2 and its fragment alcohol are respectively taken as raw materials for synthesizing structural analogues of a and b. The synthesis method has the advantage of easily available raw materials, mild reaction condition, simple operation, and high yield, the novel synthesized vitamin D2 glucoside analogue has good inhibition capability to human liver cancer cell Hep G2 and human breast cancer cell MCF-7, and has latent medicinal value.

Description

technical field

[0001] The present invention mainly relates to vitamin D 2 The glycoside analogue, its synthesis and its application belong to the field of medicinal chemistry. Background technique

[0002] As a natural natural resource, mushrooms are widely present in our life, and they have been paid attention to for a long time because of their good medicinal value. Many bioactive molecules with anticancer activity are isolated from different species of mushrooms. For example, compound a and compound b are two natural glycoside compounds extracted from plants respectively. Recently, it has been reported that compound a and compound b can inhibit the production of NO by lipopolysaccharide-stimulated macrophages and achieve the removal of peroxynitrite anion (ONOO - ) and has potential applications in the treatment of many diseases such as joint arthritis, atherosclerosis and cancer.

[0003] Vitamin D 2 As an important active substance of vitamin D, its metabolite 1,2...

Images