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A kind of preparation method of compound anti-cold soft capsule preparation

A technology of soft capsule preparation and compound formula, applied in the directions of antiviral agents, capsule delivery, pharmaceutical formulations, etc., can solve the problems of large daily dosage of patients, affecting the application, poor compliance, etc., and achieve stable quality, low environmental pollution, and drug efficacy. high effect

Active Publication Date: 2019-09-20
JILIN TONGHUA BOXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the prior art, there is no report on the use of supercritical extraction technology and microwave extraction-macroporous resin technology in the extraction and preparation of Ganmao soft capsules, and most of them use organic solvent extraction, which has a rough and backward process and many impurities, which leads to daily life of patients. The dosage is large and the compliance is poor, which seriously affects the clinical application of this product

Method used

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  • A kind of preparation method of compound anti-cold soft capsule preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The medicinal materials are dried and pulverized by a belt dryer.

[0037] Put the prescribed amount of nepeta ears and peppermint into CO 2 In the supercritical extraction device, the 1:1 mixture of absolute ethanol and acetone is used as the entrainer, and the volume percentage of the entrainer in the total extraction solvent is 5%, the extraction pressure is 20MPa, the temperature is 40°C, CO 2 The flow rate was 2mL / g crude drug·min, and the extraction was performed for 2.5 hours to obtain a supercritical extract for later use.

[0038] Put the remaining 12 herbs in the prescription into the microwave extraction device, add 80% ethanol with 4 times the amount of the herbs, extract 2 times with 500W extraction power, 8 minutes each time, combine the extracts, put them into the concentrator, recover the ethanol and Concentrate, add to a macroporous adsorption resin column, elute with 50% ethanol, collect 4 times the column volume eluate, recover ethanol under reduced ...

Embodiment 2

[0040] The medicinal materials are dried and pulverized by a belt dryer.

[0041] Put the prescribed amount of nepeta ears and peppermint into CO 2 In the supercritical extraction device, the 1:2 mixture of absolute ethanol and acetone is used as the entrainer, accounting for 4% by volume of the total extraction solvent, the extraction pressure is 16 MPa, the temperature is 35 ° C, CO 2 The flow rate is 3mL / g crude drug·min, and extraction is performed for 2 hours to obtain a supercritical extract, which is set aside.

[0042] Put the remaining 12 herbs in the prescription into the microwave extraction device, add 4 times the amount of 80% ethanol, extract 2 times, 4 minutes each time, combine the extracts, put them into the concentrator, recover the ethanol and Concentrate, add to a macroporous adsorption resin column, elute with 40% ethanol, collect 4 times the column volume eluate, recover ethanol under reduced pressure, concentrate, and dry in vacuo to obtain a dry paste....

Embodiment 3

[0044] The medicinal materials are dried and pulverized by a belt dryer.

[0045] Put the prescribed amount of nepeta ears and peppermint into CO 2 In a supercritical extraction device, a 2:1 mixture of absolute ethanol and acetone is used as an entrainer, accounting for 6% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate was 1mL / g crude drug min, and the extraction was performed for 3 hours to obtain a supercritical extract for later use.

[0046] Put the remaining 12 medicinal materials in the prescription into the microwave extraction device, add 80% ethanol of 5 times the amount of the medicinal materials, extract 2 times with 600W extraction power, 6 minutes each time, combine the extracts, put them into the concentrator, recover the ethanol and Concentrate, add to a macroporous adsorption resin column, elute with 60% ethanol, collect 5 times the column volume eluate, recover ethanol under re...

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Abstract

The invention provides a preparation method of a compound anti-cold softgel preparation. The compound anti-cold softgel preparation is prepared from Radix Platycodonis, cassia twig, Incised Notopterygium, Herbal Ephedrae, Radix Scutellariae, Radix Puerariae, bitter apricot kernel, dahurian angelica root, Chinese angelica, Divaricate Saposhnikovia Root, dahurian angelica root, Ligusticum wallichii, Acorus gramineus and mint through a supercritical extraction technology and a microwave extraction-macroporous resin technology. Compared with routine solvent extraction methods, the method provided by the invention has the advantages of simple and convenient operation, high extraction rate, short extraction time, small environmental pollution and energy saving; and the softgel preparation prepared in the invention has the advantages of stable quality and good curative effect.

Description

technical field [0001] The invention relates to a preparation method of a compound anti-cold soft capsule preparation, which belongs to the technical field of traditional Chinese medicines. [0002] technical background [0003] Although flu is a common disease, it has brought serious impact to people's life and work, and easily causes many complications simultaneously, brings threat to life. The main symptoms of a cold are headache, fever, nasal congestion, and runny nose. [0004] Ganmao Soft Capsules are included in the sixth volume of "Ministry of Health Drug Standards for Traditional Chinese Medicine Prescriptions". Antipyretic, sedative, antitussive, expectorant, anti-asthma, anti-inflammatory, anti-viral and other functions, used for headache and fever caused by exogenous wind and cold, nasal congestion, runny nose, aversion to cold without sweating, sore joints, sore throat and other symptoms . Ganmao soft capsules do not contain any kind of western medicine ingred...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/888A61K9/48A61P11/00A61P31/12
Inventor 宋爱群曲立军董守光
Owner JILIN TONGHUA BOXIANG PHARMA
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