Application of aloperine serving as drug for treating myocardial hypertrophy
A technology of cardiac hypertrophy and aloperine, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of cardiac hypertrophy without literature reports, and achieve the goal of reducing ADMA levels, reducing content, and improving activity Effect
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Embodiment 1
[0024] Aloperine is used as a drug for the treatment of cardiac hypertrophy, wherein the molecular structural formula of aloperine is as shown in formula (1):
[0025]
[0026] The single application dose of aloperine in rats is 10 mg / kg body weight, and the dosage form of the medicine is a pharmaceutically allowed powder injection dosage form.
Embodiment 2
[0028] Aloperine is used as a drug for the treatment of cardiac hypertrophy, wherein the molecular structural formula of aloperine is as shown in formula (1):
[0029]
[0030] The single application dose of aloperine in rats is 20 mg / kg body weight, and the dosage form of the medicine is an injection dosage form allowed in pharmacy.
Embodiment 3
[0032] Aloperine is used as a drug for the treatment of cardiac hypertrophy, wherein the molecular structural formula of aloperine is as shown in formula (1):
[0033]
[0034] The single application dose of aloperine in rats is 40 mg / kg body weight, and the dosage form of the medicine is an oral dosage form allowed in pharmacy.
[0035] The effect of embodiment 1-3 can be verified by following animal experiments:
[0036] 1 Experimental materials
[0037] 1.1 Animals
[0038] Spargue-Dawley (SD) rats, weighing 280-320 g, were provided by the Animal Experiment Center of Ningxia Medical University.
[0039] 1.2 Drugs, reagents and instruments
[0040] Aloperine powder (Ningxia Zijinhua Pharmaceutical Co., Ltd., purity 99%); isoproterenol; cTnI and ADMA kits; SOD, GSH-PX and MDA kits; low-temperature high-speed centrifuge; standard instrument.
[0041] 1.3 Preparation of medicine
[0042] Preparation of 0.5% sodium carboxymethylcellulose (CMC) solution: Weigh 2.5 g of C...
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