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Absorbable suture line and method for preparing the same

A technology of suture and collagen, which is applied in medical science, surgery, surgical instruments, etc., can solve the problems of high cost and slow absorption, and achieve the effect of low cost, stable and reliable absorption, and good biocompatibility

Inactive Publication Date: 2015-09-30
SUZHOU JONATHAN NEW MATERIALS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Technical problem to be solved: the present invention provides an absorbable suture and its preparation method to solve the shortcomings of absorbable suture in the prior art, such as slow absorption and high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An absorbable suture thread, mainly made of the following raw materials in proportion by mass: 24 parts of collagen, 23 parts of silk protein, 12 parts of silk fibroin, 13 parts of sericin, 12 parts of glycolic acid, 11 parts of lactic acid, poly 2 parts of glycolide, 6 parts of polylactide, 4 parts of polyglycolide lactide, 1 part of sodium carbonate, 40 parts of deionized water.

[0027] A preparation method for absorbable sutures, comprising the following steps:

[0028] (1) Dissolve sodium carbonate in deionized water to prepare a base solution, the mass concentration of sodium carbonate is 3%;

[0029] (2) Dissolve collagen, silk protein, silk fibroin and sericin in the base liquid obtained in step (1), and stir until completely dissolved;

[0030] (3) Put glycolic acid, lactic acid, polyglycolide, polylactide and polyglycolide lactide in a reaction kettle to make a melt at a temperature of 230°C and a pressure of 1.3MPa, and After drying and crushing, it is made...

Embodiment 2

[0034] An absorbable suture thread, mainly made of the following raw materials according to the ratio of parts by mass: 48 parts of collagen, 46 parts of silk protein, 21 parts of silk fibroin, 18 parts of sericin, 16 parts of glycolic acid, 22 parts of lactic acid, poly 11 parts of glycolide, 17 parts of polylactide, 12 parts of polyglycolide lactide, 5 parts of sodium carbonate, 60 parts of deionized water.

[0035] A preparation method for absorbable sutures, comprising the following steps:

[0036] (1) Dissolve sodium carbonate in deionized water to prepare a base solution, the mass concentration of sodium carbonate is 6%;

[0037] (2) Dissolve collagen, silk protein, silk fibroin and sericin in the base liquid obtained in step (1), and stir until completely dissolved;

[0038] (3) Put glycolic acid, lactic acid, polyglycolide, polylactide and polyglycolide lactide in a reaction kettle to make a melt at a temperature of 325°C and a pressure of 2.4MPa, and After drying an...

Embodiment 3

[0042] An absorbable suture thread, mainly made of the following raw materials in proportion by mass: 55 parts of collagen, 56 parts of silk protein, 27 parts of silk fibroin, 23 parts of sericin, 30 parts of glycolic acid, 28 parts of lactic acid, poly 14 parts of glycolide, 20 parts of polylactide, 16 parts of polyglycolide lactide, 7 parts of sodium carbonate, 65 parts of deionized water.

[0043] A preparation method for absorbable sutures, comprising the following steps:

[0044] (1) Sodium carbonate was dissolved in deionized water to prepare a base solution, and the mass concentration of sodium carbonate was 8%;

[0045] (2) Dissolve collagen, silk protein, silk fibroin and sericin in the base liquid obtained in step (1), and stir until completely dissolved;

[0046] (3) Put glycolic acid, lactic acid, polyglycolide, polylactide and polyglycolide lactide in a reaction kettle to make a melt at a temperature of 360°C and a pressure of 2.7MPa, and After drying and crushi...

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Abstract

The invention discloses an absorbable suture line and a method for preparing the same. The absorbable suture line is mainly prepared from, by mass parts, 24-55 parts of collagen, 23-56 parts of silk protein, 12-27 parts of fibroin, 13-23 parts of sericin, 12-30 parts of glycolic acid, 11-28 parts of lactic acid, 2-14 parts of polyglycolide, 6-20 parts of polylactide, 4-16 parts of poly glycolide-co-lactide, 1-7 parts of sodium carbonate and 40-65 parts of deionized water. The absorbable suture line has the advantages that the absorbable suture line prepared according to the scheme is high in degree of fusion with the human body, can be completely absorbed by the human body, is absorbed stably and reliably, causes no obvious individual difference and is free of toxic and side effects; the absorbable suture line prepared according to the scheme is high in tensile strength and good in biocompatibility and promotes cell growth; and the absorbable suture line prepared according to the scheme has convenience in material taking and is low in cost.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to an absorbable suture and a preparation method thereof. Background technique [0002] Surgical sutures refer to special threads used for suturing hemostasis and tissue suturing in surgical operations or in trauma treatment. Generally, it can be divided into two categories: absorbable sutures and non-absorbable sutures: absorbable sutures can be divided into catgut, chemically synthesized sutures, and pure natural collagen sutures according to the material and degree of absorption. [0003] Sheep catgut is made from healthy animal sheep intestines and contains collagen, so there is no need to remove the sutures after suturing. There are two types of medical gut: common gut and chrome gut, both of which can be absorbed. The length of time required for absorption depends on the thickness of the gut and the condition of the tissue. Generally, it can be absorbed within 6 to 20 day...

Claims

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Application Information

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IPC IPC(8): A61L17/12A61L17/10
Inventor 吕少波李卓才李苏杨
Owner SUZHOU JONATHAN NEW MATERIALS TECH
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