Novel application of ginseng in preparing drug for preventing and/or treating microglial cell medicated diseases

A technology of microglia and new uses, which is applied in the field of new uses of ginseng in the preparation of drugs for preventing and/or treating microglia-mediated diseases, can solve the problem of no reports of ginseng or ginseng extracts preventing and treating amyotrophic spinal cord Lateral sclerosis, no immune toxicity reported in the literature, etc., to achieve a significant effect

Inactive Publication Date: 2015-10-07
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, there is currently no literature reporting that ginseng or ginseng extracts can inhibit microglia-related immunotoxicity, and there is no report that ginseng or ginseng extracts can prevent and treat diseases such as amyotrophic lateral sclerosis, AIDS-related dementia, and mad cow disease

Method used

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  • Novel application of ginseng in preparing drug for preventing and/or treating microglial cell medicated diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation of ginseng extract

[0041] 1) Take ginseng medicinal materials and add water to extract, and the extract is concentrated into a ginseng extract containing 25% solids;

[0042] 2) After the ginseng extract is degreased, it is purified by D-type macroporous resin, washed with water: 95% ethanol according to the gradient elution method to remove the ginseng triol glycosides components and most of the ginseng diol glycosides components outside Rd, and then separately with 70 % ethanol elutes the saponins mainly composed of ginsenoside Rd, collects the eluate and decolorizes it, recovers the solvent, concentrates it, and dries it under reduced pressure to make a dry product;

[0043] 3) The dry product is dissolved in 95.0% ethanol, and the insoluble matter is filtered out with a 50 μm filter membrane. After being absorbed by a monodisperse polymeric silica gel chromatography column, it is eluted and purified with water: the concentration is 95...

Embodiment 2

[0045] Embodiment 2: the preparation of ginseng extract

[0046] 1) Take ginseng medicinal materials and add ethanol with a concentration of 25% for extraction, recover ethanol from the extract to obtain a ginseng extract containing 20% ​​solids;

[0047] 2) After the ginseng extract is degreased, it is purified by D-type macroporous resin, washed with water: 95% ethanol according to the gradient elution method to remove the ginseng triol glycosides components and most of the ginseng diol glycosides components other than Rd, and then separately with 95 % ethanol elutes the saponins mainly composed of ginsenoside Rd, collects the eluate and decolorizes it, recovers the solvent, concentrates it, and dries it under reduced pressure to make a dry product;

[0048] 3) The dry product is dissolved in 96% ethanol, and the insoluble matter is filtered out with a 45 μm filter membrane, and after being absorbed by a monodisperse polymeric silica gel chromatography column, it is eluted a...

Embodiment 3

[0050] Embodiment 3: the preparation of ginseng extract

[0051] 1) Take the ginseng medicinal material and extract it with 96% ethanol, recover the ethanol from the extract to obtain a ginseng extract containing 5% solids;

[0052] 2) After the ginseng extract is degreased, it is purified by D-type macroporous resin, washed with water: 95% ethanol according to the gradient elution method to remove the ginseng triol glycosides components and most of the ginseng diol glycosides components other than Rd, and then separately with 95 % ethanol solution to elute the saponins mainly composed of ginsenoside Rd, collect the eluent and decolorize it, recover the solvent, concentrate, dry under reduced pressure, and make a dry product;

[0053] 3) The dry product is dissolved in 98.0% ethanol, and the insoluble matter is filtered out with a 1 μm filter membrane, and then absorbed by a monodisperse polymeric silica gel chromatography column, and purified by gradient elution with water: t...

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Abstract

The invention relates to a novel application of ginseng and ginseng extract, and particularly relates to a novel application of ginseng and ginseng extract in preparing a drug for treating microglial cell medicated diseases, and more particularly relates to a novel application of a novel application of a medicine preparation with content of ginsenoside Rd more than or equal to 50 percent in the ginseng extract in preparing a drug for treating microglial cell mediated diseases.

Description

technical field [0001] The present invention relates to a new application of ginseng, especially a new application of ginseng extract, that is, a new application in the preparation of drugs for preventing and / or treating diseases mediated by microglial cells. Background technique [0002] Abnormal activation of microglia plays an important role in multiple sclerosis and other diseases, and is one of the main causes of nerve damage in the pathological development of the above diseases. Under pathological conditions, small changes in the microenvironment can activate microglia, and the activated microglia can up-regulate the secretion levels of many neurotoxic factors, such as nitric oxide (NO), reactive oxygen species (ROS) and peanut-like Acids (such as prostaglandin E2), etc., leading to secondary brain damage. Therefore, inhibiting the excessive activation of microglia can effectively prevent and treat diseases such as multiple sclerosis and multiple sclerosis. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P25/28A61P25/00A61P31/12
Inventor 许淑清王少峡黄宇声胡利民李钊文郭虹刘冠萍孟凡英郑志远张栩颜
Owner GUANGXI WUZHOU PHARMA GRP
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