59results about How to "Inhibition inhibition" patented technology

The invention discloses a supported noble-metal hydrogenation catalyst, and a preparation method and an application of the catalyst. The catalyst is prepared according to the following steps: (1) preparing a mixed solution consisting of water, an alcohol and tetraethyl orthosilicate; (2) pouring activated carbon into the mixed solution obtained in the step (1) and performing stirring, then adding a soluble noble metal salt, regulating the pH value of the slurry to a range of 0.5-2.5, and performing stirring aging to obtain a reaction slurry; (3) adding a base liquor into the reaction slurry to regulate the pH value to a range of 7.5-14, wherein the basic substance in the base liquor is one or a combination of more selected from a group consisting of potassium hydroxide, cesium hydroxide, potassium acetate, cesium acetate, potassium carbonate and cesium carbonate, continuing to perform stir, and finally performing filtering and washing to obtain a catalyst precursor; and (4) performing reduction on the catalyst precursor to obtain the supported noble-metal hydrogenation catalyst. The invention provides an application of the catalyst in catalyzing hydrogenation synthesis of amino phenyl ether compounds which are represented as a formula II by using compounds which are represented as a formula II, the conversion rate reaches 100%, the selectivity can reach 99.5% or more, and the catalyst can be used for 50 times or more.

The invention provides a pyrimidine compound, and the structure of the pyrimidine compound is shown in the following formulas (I) and (II), wherein R is substituted phenyl or substituted pyridyl; R1 is -NO2, -Br, -COOH or -OCH3; n is an integer of 1-3; X is -Br or CI; and R8, R9 and R10 are identical or different -H, -OCH3, -COOMe, -Br, -COOEt, -CH2COOMe, -NO2 or (CH2)1-4OH. The pyrimidine compound provided by the invention has an effect of FAK inhibition, can effectively enter tumor cells, has a good effect of inhibiting the tumor cells and can be better detained. The invention also provides a preparation method of the compound and the application of the compound to the preparation of preparing a tumor inhibitor.