59results about How to "Inhibition inhibition" patented technology

The invention discloses a turmeric pigment-metal ion complex made by reaction of turmeric pigment and metal salt in any one or mixed solvent of alcohol solvent and acetone. It also discloses the making method and the application of making drugs to cure tumor or hepatitis. It can largely improve the water-solubility and stability of the turmeric pigment and be made into many solvents such as oral preparation and injection, etc.

The invention discloses a method for preparing walnut polypeptide nano-selenium with anti-tumor activity. The method comprises the following steps: (1) performing limited enzymatic hydrolysis on walnut dreg; (2) concentrating, and spray-drying to obtain walnut polypeptide; (3) adding an inorganic selenium source and vitamin C into the walnut polypeptide solution to prepare functional nano-selenium sol; (4) dialyzing the sol; and (5) carrying out freeze drying to obtain the walnut polypeptide nano-selenium. The dissolved walnut polypeptide nano-selenium is orange sol, and the morphology of the polypeptide nano-selenium is observed by a scanning electron microscope, and nano-particles with uniform particle size can be observed. The walnut polypeptide nano-selenium disclosed by the invention can be used for preparing selenium supplement agent healthy products and medicines. Cell experiments prove that the sol has a remarkable anti-tumor bioactivity, and is expected to become a high-efficiency low-toxicity preparation for treating cancers, in particular breast cancer.

The invention provides a pyrimidine compound, and the structure of the pyrimidine compound is shown in the following formulas (I) and (II), wherein R is substituted phenyl or substituted pyridyl; R1 is -NO2, -Br, -COOH or -OCH3; n is an integer of 1-3; X is -Br or CI; and R8, R9 and R10 are identical or different -H, -OCH3, -COOMe, -Br, -COOEt, -CH2COOMe, -NO2 or (CH2)1-4OH. The pyrimidine compound provided by the invention has an effect of FAK inhibition, can effectively enter tumor cells, has a good effect of inhibiting the tumor cells and can be better detained. The invention also provides a preparation method of the compound and the application of the compound to the preparation of preparing a tumor inhibitor.

The present invention relates to a compound having a structure of formula I or a pharmaceutically acceptable salt of the compound. Regarding the compound, R1 is selected from hydrogen, fluorine, and chlorine; R2 and R3 are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, and aryl, wherein R2 and R3 can be bonded to forma ring, and the ring can be cycloalkyl, substituted cycloalkyl, an aromatic heterocyclic ring or a non-aromatic heterocyclic ring; R4 is selected from hydrogen, cyano, alkyl, substituted alkyl, alkene or substituted alkenyl, alkynyl or substituted alkynyl, and aryl; R5 is selected from hydrogen, halogen, and haloalkyl. The invention further relates to a pharmaceutical composition comprising the compound. The compound and composition provided by the invention shows significant activity in the treatment of prostate cancer. (The formulas are shown in the description.).

The present invention discloses a Chinese medicine for curing common cold, which is made up by using 6 Chinese medicinal materials of forsythia fruit, lonicera flower, sweet wormwood, bupleurum root, bitter apricot kernel and platycodon root as raw material through the a certain preparation process. Said medicine has the functions of clearing away heat and toxic material, resisting virus, resisting bacteria, resisting inflammation and relieving cough, and is suitable for curing wind-heat type common cold.

The invention provides electron aerosolization liquid with a human body function nursing effect and a preparing method thereof. The electron aerosolization liquid mainly comprises, by weight, the components of 0.05-2.6 parts of natural nicotine, 3-18 parts of tobacco absolute oil, 0.1-0.5 part of taurine, 0.05-0.1 part of asparaginic acid, 0.03-0.08 part of isoleucine, 0.4-5 parts of hawthorn tincture, 0.5-5 parts of folium artemisiae argyi extract, 26-50 parts of USP-grade glycerinum and the balance food-grade propylene glycol. Damage to a human body from nicotine is lowered, meanwhile, body health can be well achieved, and the human body function nursing effect is achieved.

The invention discloses anti-infection application of a thiazole-structure--containing compound. The thiazole-structure-containing compound has inhibition functions on virulence factors of pseudomonasaeruginosa of Gram-negative bacteria and virulence factors of staphylococcus aureus of Gram-positive bacteria, and ML364 in the composition is capable of increasing survival rates of mice suffering from general infection caused by carbapenem-medicine-resistant pseudomonas aeruginosa and methicillin-medicine-resistant staphylococcus aureus by 60% respectively.

The invention provides an application of a combination of a sulfhydryl oxidase 1 agonist and sorafenib in preparation of liver cancer treatment cells. The sulfhydryl oxidase 1 agonist comprises lentivirus for overexpression of sulfhydryl oxidase 1 and recombinant sulfhydryl oxidase 1 protein; firstly, lentivirus for overexpression of sulfhydryl oxidase 1 is constructed, and then target cells are transfected; and the dosage forms of the sulfhydryl oxidase 1 agonist comprise an oral preparation, an injection or a sustained release preparation and the like. The lentivirus for overexpression of QSOX1 and sorafenib are used for acting on liver cancer cells at the same time, QSOX1 can inhibit the activity of the liver cancer cells, the GSH content can be more obviously reduced, the free ferrousions in the cells and the lipid peroxidation level are increased, and thus cell ferroptosis is promoted; and therefore, the lentivirus for overexpression of QSOX1 is combined with sorafenib, so that the inhibition effect on tumor growth is promoted synergistically, and a stronger killing effect is achieved.

The invention provides the application of a soft capsule capable of clearing heat and eliminating toxin in the preparation of a medicament for treating viral pneumonia, wherein the soft capsule capable of clearing heat and eliminating toxin comprises active components prepared from the following raw materials in parts by weight: 670 parts of gypsum, 134 parts of honeysuckle, 107 parts of figwort root, 80 parts of rehmannia root, 67 parts of forsythia, 67 parts of cape jasmine fruit, 67 parts of Chinese violet, 67 parts of baical skullcap root, 67 parts of Chinese gentian, 67 parts of indigowoad root, 54 parts of anemarrhena asphodeloides bunge and 54 parts of dwarf lilyturf tuber. Results of clinical tests of the soft capsule show that: when the soft capsule capable of clearing heat and eliminating toxin is adopted, pulmonary indexes can be reduced; and moreover, the soft capsule has an obvious inhibition effect on the mouse viral pneumonia caused by virus infection, and can be used for preparing the medicament for treating the viral pneumonia.

The invention discloses a picea koraiensis tissue culture medium and a culture method. The method comprises the following steps: selecting picea koraiensis dormant buds, needles or tender stems as explants, and performing disinfection treatment; pretreating the explants before induction, and soaking the explants in an 8g / L NaCl solution for 3-5 minutes; performing callus tissue induction; performing proliferation of callus tissue; and inducing differentiation of buds. Based on the superiority of tissue culture, the method provided by the invention can solve the problems of low reproductive rate, low yield and the like of traditional manners of seed propagation, cutting propagation and the like to the greatest extent, and realizes the tissue culture of picea koraiensis; in addition, the success rate of taking dormant buds as the explants is the highest; and besides, the possibility of taking needles, tender stems and the like as the explants is also provided, so that the tissue cultureof the picea koraiensis is not only limited to picking the dormant buds in winter, but induction can still be performed by picking the needles and the tender stems in spring.

The invention relates to a medicine composed of Chinese traditional medicine FSE with functions of d-vacciniin, in particular to the medicine taking the FSE as the active ingredient. Combined with related auxiliary materials, the medicine can be prepared into various dosage forms acceptable for physic, especially the pill and the soft capsule. The invention not only reserves the d-vacciniin of the FSE, but also saves and utilizes the medicine and exerts the medicine in largest extention with small dose.

Disclosed is an externally-used medicament for alleviating pains of patients and the preparing process, wherein the medicament is prepared from the raw materials of corydalis tuber, secretio bufonis, frankincense, myrrh, burred tuber, zedoary, borneol, amber, bark of peony root, root of herbaceous peony, Chinese angelica root, Ligusticum wallichii, goldthread root, Chinese dittany bark, green tangerine orange peel, immature bitter orange, pinellia tuber and mustard seed.

The invention discloses a supported noble-metal hydrogenation catalyst, and a preparation method and an application of the catalyst. The catalyst is prepared according to the following steps: (1) preparing a mixed solution consisting of water, an alcohol and tetraethyl orthosilicate; (2) pouring activated carbon into the mixed solution obtained in the step (1) and performing stirring, then adding a soluble noble metal salt, regulating the pH value of the slurry to a range of 0.5-2.5, and performing stirring aging to obtain a reaction slurry; (3) adding a base liquor into the reaction slurry to regulate the pH value to a range of 7.5-14, wherein the basic substance in the base liquor is one or a combination of more selected from a group consisting of potassium hydroxide, cesium hydroxide, potassium acetate, cesium acetate, potassium carbonate and cesium carbonate, continuing to perform stir, and finally performing filtering and washing to obtain a catalyst precursor; and (4) performing reduction on the catalyst precursor to obtain the supported noble-metal hydrogenation catalyst. The invention provides an application of the catalyst in catalyzing hydrogenation synthesis of amino phenyl ether compounds which are represented as a formula II by using compounds which are represented as a formula II, the conversion rate reaches 100%, the selectivity can reach 99.5% or more, and the catalyst can be used for 50 times or more.

The invention pertains to the technical field of medicine, relating to new compounds which have hepatoprotective activity or stereoisomer and salt thereof, the preparation methods of the compounds or the stereoisomer thereof, medical compositions which comprise the compounds or the stereoisomer and salt thereof as necessary active ingredients, and the application of the compounds or the stereoisomer and salt thereof in the preparation of medicine to cure and / or prevent hepatopathy and inflammatorydisease. The compounds or the stereoisomer and salt thereof of the invention have prominent functions of resisting acute and chronic hepatic injury and good function of antivirus at the same time, as well as prominent anti-inflammatory activity.

The invention discloses a method for inhibiting the activity of amylase. The method is characterized in that starch nano-particles are prepared through a retrogradation technology and an anti-solventtechnology, and are used as a material for inhibiting the activity of alpha-amylase, that is starch and chitin are used to prepare the nano-particles, and the alpha-amylase is adsorbed by the nano-particles at a most suitable pH value in order to inhibit the activity of the alpha-amylase. The highly-stable and uniformly-distributed starch nano-particles and chitin whiskers are adopted to adsorb the alpha-amylase, and the starch nano-particles are rapidly combined with the active sites of the alpha-amylase to form an alpha-amylase-starch nano-particle compound in order to obstruct the combination of the alpha-amylase and soluble starch, so the content of the aphla-amylase combined with the soluble starch substrate is reduced, thereby the activity of the alpha-amylase is inhibited. The method for preparing alpha-amylase having low activity has the advantages of simplicity, easiness in operation, low cost, and suitableness for large-scale production, and is applied to the food and medicine industries.

The invention discloses a nano seed coating agent, relates to the technical field of ecological agriculture, and aims to solve the problem that a seed coating agent in the prior art cannot adapt to various environmental conditions. The invention is mainly prepared from the following raw materials in parts by weight: 2-200 parts of modified attapulgite, 2-40 parts of amino silicone oil, 2-40 partsof nanoscale silicon dioxide, 2-200 parts of calcium peroxide and 520-992 parts of ethanol. The beneficial effects of the invention are that seeds are effectively coated by the nano seed coating agent, a reticular nano protective layer is formed on the surfaces of the seeds, and the protective layer not only can efficiently absorb moisture in soil and air, but also can prevent the absorbed moisture from losing, so that the seeds can obtain the moisture required by germination under a relatively dry environment condition.

A composite Chinese medicine in the form of orally taken medicine and injection for treating the diseases in urinary system and reproductive system is proportionally prepared from Touhua knotweed or its extract, imperate rhizome or its extract, and optional cephalanoplos herb or its extract. Its preparing process is also disclosed.

Disclosed is a method for preparing a bamboo fungus polysaccharide-zinc chelate. The method comprises the following steps: (1) extracting the bamboo fungus polysaccharide; (2) separating the bamboo fungus polysaccharide; (3) purifying the bamboo fungus polysaccharide; (4) adding an inorganic zinc source into the bamboo fungus polysaccharide for a chelation reaction; (5) ethanol precipitation; and (6) lyophilization, thereby obtaining the bamboo fungus polysaccharide-zinc chelate. The bamboo fungus polysaccharide-zinc chelate is used for preparing zinc-replenishing health products and drugs, and the chelate also has anti-tumour biological activity.

The invention provides a pyrimidine compound, and the structure of the pyrimidine compound is shown in the following formulas (I) and (II), wherein R is substituted phenyl or substituted pyridyl; R1 is -NO2, -Br, -COOH or -OCH3; n is an integer of 1-3; X is -Br or CI; and R8, R9 and R10 are identical or different -H, -OCH3, -COOMe, -Br, -COOEt, -CH2COOMe, -NO2 or (CH2)1-4OH. The pyrimidine compound provided by the invention has an effect of FAK inhibition, can effectively enter tumor cells, has a good effect of inhibiting the tumor cells and can be better detained. The invention also provides a preparation method of the compound and the application of the compound to the preparation of preparing a tumor inhibitor.

The invention relates to a novel application of ginsenoside Rd in preparing a drug for treating microglial cell mediated diseases, and particularly relates to a novel application of ginsenoside Rd in preparing a drug for treating diseases such as disseminated sclerosis, amyotrophic lateral sclerosis, HIV-associated dementia, mad cow disease and the like.

A Chinese emdicine for treatingsore throatand aphthae is prepared from artificial bezoar and scutellaria root.

The invention relates to a kelp root hypoglycemic product and a preparation method and application thereof. The preparation method comprises the following steps: taking kelp roots to extract with ethanol for multiple times, and adding an antioxidant during the extraction process to obtain an extract concentrate; adding the extract concentrate into an extraction solution for extraction, adding theantioxidant during the extraction process, and drying to obtain the kelp root hypoglycemic product. The kelp roots as a raw material used in the method are sufficient, the kelp root hypoglycemic product has a definite hypoglycemic effect and no toxic or side effects, and is a safe and effective hypoglycemic product; the kelp root hypoglycemic product has a significant inhibitory effect on alpha-glucosidase, the IC50 reaches 140mu g / ml, and the kelp root hypoglycemic product is a non-competitive inhibitor of the alpha-glucosidase. Through addition of the antioxidant vitamin C, the hypoglycemic effect IC50 is improved by one time or more compared with that of the hypoglycemic product in the prior art, and the yield of the product is increased by multiple times.

The invention relates to a laminaria japonica root hypoglycemic product and a preparation method and application thereof. The preparation method comprises the following steps that laminaria japonica roots are taken and extracted for multiple times through ethyl alcohol, an antioxidant is added during the extraction process, and an extracted concentrate is obtained; and extract liquor is added into the extracted concentrate for extraction, an antioxidant is added in the extraction process, drying is conducted, and the laminaria japonica root hypoglycemic product is obtained. The laminaria japonica roots used in the preparation method is sufficient in raw material, and the laminaria japonica root hypoglycemic product is definite in hypoglycemic effect and free of toxic and side effects, and is a safe and effective hypoglycemic product; the hypoglycemic product obtained through the preparation method has an obvious inhibition effect on alpha-glucosidase, reaches 140 [mu]g / ml in IC50, and is a noncompetitive inhibitor to the alpha-glucosidase; and an antioxidant vitamin C is added, compared with the prior art, the hypoglycemic effect IC50 is doubled or above, and meanwhile, the product yield is increased by several times.

The invention provides a preparation method of instant fermented bean curd. The preparation method comprises the following steps: A) soaking soybeans, grinding into thick liquid, boiling the thick liquid, curdling and squeezing to obtain white blanks; B) inoculating mucor on the surface of the white blank, and culturing to obtain a fermented bean curd blank; C) sugaring the fermented bean curd blank to obtain a sugaring blank; and D) bottling the sugared fermented bean curd blank, adding the blended soup, fermenting and sterilizing to obtain the product. A preparation method of the blended soup specifically comprises the following steps: mixing fruit vinegar and salt, sterilizing and cooling. The sugar is used for replacing salt used in traditional fermentation to pickle the fermented bean curd blank, so that 1, the salt content of the finished product fermented bean curd is reduced, and the fermented bean curd is beneficial to human health; 2, the treatment cost of the high-concentration salt wastewater is reduced; 3, the sugar waterlogging can be repeatedly used, so that the production cost is saved; the fruit vinegar is used as a fermentation carrier, and the fruit vinegar contains acetic acid and a low-pH environment, so that the growth of infectious microbes can be effectively inhibited. Meanwhile, the fermented bean curd is endowed with a special fruity flavor.

The invention relates to a novel application of ginseng and ginseng extract, and particularly relates to a novel application of ginseng and ginseng extract in preparing a drug for treating microglial cell medicated diseases, and more particularly relates to a novel application of a novel application of a medicine preparation with content of ginsenoside Rd more than or equal to 50 percent in the ginseng extract in preparing a drug for treating microglial cell mediated diseases.

The invention discloses a pinus sylvestris tissue culture medium and a rooting method. The rooting method comprises the following steps: selecting a tender needle leaf part of pinus sylvestris as an explant, and performing sterilization and disinfection treatment; soaking the explant into a NaCl solution for pretreatment before induction; inducing calluses; performing proliferation of the calluses; and performing rooting culture. By adopting the method for inducing and culturing the pinus sylvestris callus, the problems of high difficulty and low efficiency of an existing pinus sylvestris tissue culture technology are solved. The invention solves the problem of selection of tissue culture explants of pinus sylvestris plants, and provides a tissue culture method for induced differentiation,proliferation and rooting. The pinus sylvestris tissue culture medium and the rooting method are of great significance to breeding of pinus sylvestris and other coniferous plants, and have great ecological and economic significance.

The invention relates to a snake gourd plantation method comprising the following steps of seedling growing, soil preparation, base fertilizer application, field planting, rack establishment, and harvesting. By utilization of the plantation method, the weight, the number of gourds on each plant and the gourd length of snake gourds are obviously increased relative to a control group. The plantation method is beneficial to growth of the snake gourds, and pesticide residual in the plants can be reduced, thereby facilitating human consumption.

The invention provides a folium sauropi extract with anti-inflammatory and antitussive effects. The provided folium sauropi extract is extracted from the leaf portion of the folium sauropi from the euphorbiaceae and can be used for preparing medicines for inflammation resistance, lung-heat cough and panting and excessive phlegm, asthma, internal injury, tuberculosis and aphonia, laryngalgia and the like; in addition, the folium sauropi extract has the advantages of low toxicity, small side effects and simplicity and convenience in operation of preparation process, low production cost and suitability for large-scale industrial production. The invention also relates to a folium sauropi extract preparation. The folium sauropi extract preparation has the advantages of being obvious in anti-inflammatory and antitussive effects, convenient to take and the like.

The invention provides application of RNA binding protein Ythdf3, a target spot for treating nerve axon injury and a medicine, and relates to the technical field of biomedicine. The RNA binding protein Ythdf3 is used as a molecular target spot for regulating and controlling regeneration of nerve axon after peripheral and central nerve injury. According to the application of the RNA binding protein Ythdf3, research shows that expression of in-vitro and in-vivo interference Ythdf3 genes can remarkably inhibit growth of neuron axon. In addition, the regeneration process of sciatic nerve axon can be promoted by overexpression of Ythdf3 in DRG. Meanwhile, the inhibition effect of Ythdf3 gene interference on neuron axon can be inhibited by overexpression of a downstream important regulation and control target gene Foxo3 of Ythdf3. The research shows that Ythdf3 possibly influences growth of neuron axon by adjusting expression of the Foxo3 gene, and can become an important molecular target spot for nerve injury repair.

The invention discloses use of a beta-carboline alkaloid GAK in preparation of products for treating and / or preventing pulmonary fibrosis. According to the use, the bioactivity of the beta-carboline alkaloid GAK in treatment on the pulmonary fibrosis is researched, and the condition that the beta-carboline alkaloid GAK has a relatively good improvement action on body weight, survival rate, pulmonary index and tissue pathological changes of PF mice and is dose-dependent is verified. A Masson staining and hydroxyproline assaying result shows that the GAK can be used for obviously inhibiting collagen deposition of pulmonary tissue; and an immunization fluorescence staining result shows that an epithelial cell marker protein E-Cadherin in the pulmonary tissue of mice of a GAK-dosed group is increased obviously, an interstitial cell marker protein alpha-SMA in the pulmonary tissue is decreased obviously, and thus, the GAK has an obvious inhibiting action on an EMT process of a fibrosis stage. The above results show that the GAK has anti-PF activity in an animal body, a theoretical foundation is provided for researching and developing natural product drugs for treating the pulmonary fibrosis, and the GAK is advantageously used for treating the pulmonary fibrosis.