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Ginger-yellow pigment metal-ion complex, its preparation method and use

A technology of curcumin and metal ions, which is applied in the field of preparation of curcumin metal ion complexes, can solve the problems of poor stability, limiting the application of curcumin, and low solubility, and achieve rapid onset of effect, good therapeutic effect, and effective onset fast effect

Inactive Publication Date: 2003-08-27
吴梅春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since curcumin and its constituents curcumin, demethoxycurcumin, and bisdemethoxycurcumin are all fat-soluble compounds, their solubility in water is very small and their stability is poor, and there are only oral preparations and For external use, there are currently no curcumin and its preparations, especially injections, with high water solubility, good stability, rapid onset of action, and high bioavailability, which limits the further clinical application of curcumin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Curcumin Calcium Complex

[0023] Take 20 g of curcumin, dissolve it in a mixed solution of 1000 ml of ethanol and acetone (volume ratio 4:1), and keep it warm at 40-50° C. for 2 h for later use. Separately weigh 5g of anhydrous calcium chloride, dissolve it in 100ml of ethanol for later use; add the ethanol solution of calcium chloride to the mixed solution of curcumin, keep it warm for 2-3 hours, adjust the pH of the above solution to 7-8 with ammonia water, and let it stand overnight; filter and separate the precipitated curcumin calcium complex, wash with ethanol, and dry at 70-80°C to obtain the curcumin calcium complex of the present invention.

Embodiment 2

[0025] Preparation of Curcumin Copper Complex

[0026] Take 25g of curcumin, dissolve it in 1000ml of ethanol-acetone (volume ratio 3:1) mixed solution, and keep it warm at 50°C for 4h for later use. Separately weigh 6g of copper chloride, dissolve it in 150ml of ethanol for later use; add the copper chloride ethanol solution to the curcumin mixed solution, keep it warm for 4 hours, adjust the pH of the above solution to 8 with ammonia water, and let it stand for 24 hours; filter and separate the curcumin The copper complex is precipitated, washed with ethanol, and dried at 70-80°C to obtain the curcumin copper complex of the present invention.

Embodiment 3

[0028] Preparation of Curcumin Calcium Complex Powder Injection

[0029] Turmeric Calcium Complex 100g

[0030] Mannitol 100g

[0031] PVPk30 20g

[0032] Meglumine 30g

[0033] Add water for injection to 5000ml

[0034] Take meglumine, mannitol, PVPK30, add water for injection 4500ml, heat and stir to dissolve, and continue to heat. When the temperature rises to 65°C, add the curcumin-calcium complex, keep warm and stir until completely dissolved. Cool to room temperature, adjust the pH to 8.0 with 10% citric acid, adjust the volume to 5000ml, and filter through 0.65 μm and 0.22 μm microporous membranes respectively to obtain a clear filtrate. Under aseptic conditions, fill in sterilized 7ml vials (5ml / bottle), freeze-dry, stopper and cap after freeze-drying, get 1000 bottles of curcumin-calcium complex freeze-drying of the present invention powder injection.

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Abstract

The invention discloses a turmeric pigment-metal ion complex made by reaction of turmeric pigment and metal salt in any one or mixed solvent of alcohol solvent and acetone. It also discloses the making method and the application of making drugs to cure tumor or hepatitis. It can largely improve the water-solubility and stability of the turmeric pigment and be made into many solvents such as oral preparation and injection, etc.

Description

Technical field [0001] The invention relates to a curcumin metal ion complex, and at the same time, the invention also relates to a preparation method and application of the curcumin metal ion complex. Background technique [0002] Curcumin is a natural pigment extracted from traditional Chinese medicines turmeric, turmeric, and zedoary. It mainly contains three components: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. It has been widely used in food, cosmetics and medicines. A large number of pharmacological studies have shown that curcumin has various pharmacological effects such as lipid-lowering, anti-cancer and anti-cancer, choleretic, anti-inflammatory, anti-radiation, anti-oxidation, and antibacterial. Since curcumin and its constituents curcumin, demethoxycurcumin, and bisdemethoxycurcumin are all fat-soluble compounds, their solubility in water is very small and their stability is poor, and there are only oral preparations and For external preparations, t...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K31/30A61P1/16A61P31/12C07C49/255C07F1/02C07F1/08C07F3/04C07F3/06
Inventor 吴梅春
Owner 吴梅春
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