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Laminaria japonica root hypoglycemic product and preparation method and application thereof

A technology for lowering blood sugar and kelp root, applied in the field of medicine, can solve the problems of low activity of hypoglycemic components, and achieve the effects of no toxic and side effects, improved IC50, and improved yield

Inactive Publication Date: 2017-03-29
QINGDAO JIARILONG SEAFOOD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present invention aims to provide a kelp root hypoglycemic product and its preparation method and application, so as to solve the problem of low activity of the above-mentioned hypoglycemic components

Method used

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  • Laminaria japonica root hypoglycemic product and preparation method and application thereof
  • Laminaria japonica root hypoglycemic product and preparation method and application thereof
  • Laminaria japonica root hypoglycemic product and preparation method and application thereof

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preparation example Construction

[0021] Disclosed is a preparation method of a kelp root hypoglycemic product, comprising the following steps: taking kelp root and extracting it multiple times with ethanol, adding antioxidants during the extraction process to obtain an extraction concentrate; adding the extraction concentrate to an extraction liquid for extraction, the extraction process Antioxidants are added and dried to obtain the hypoglycemic product of kelp root. Preferably, the antioxidant is vitamin C.

[0022] Among them, the active ingredients contained in the hypoglycemic substance extracted from kelp root are easy to oxidize, adding antioxidants during the extraction and separation process can significantly increase the content of the hypoglycemic substance. Antioxidants can also be vitamin A, vitamin E, and glutathione. Adding the antioxidant vitamin C during the extraction process increases the IC50.

[0023] In some illustrative embodiments, the extraction process or the amount of antioxidant a...

Embodiment 1

[0028] Take 100kg of naturally air-dried kelp root, dry at 60°C for 24 hours, take it out, grind it into powder, pass through a 60-mesh sieve, add more than 80% ethanol according to the solid-liquid ratio of 1:5, and add 0.1% vitamin C at the same time, and reflux at 60°C Extract for 2 hours, filter the extract, extract the filter residue twice according to the above method, combine the filtrate, and dry under reduced pressure to obtain the extract concentrate of kelp root.

[0029] Add 5 times the amount of ethyl acetate and 0.1% vitamin C to the extract concentrate obtained from kelp root, stir and extract at room temperature for 24 hours, siphon the upper layer solution, and extract the lower layer precipitation twice with the same method, combine the extracts, reduce Press and dry to obtain the product A for lowering blood sugar of seaweed root.

Embodiment 2

[0031] Take 100kg of naturally air-dried kelp root, dry it at 60°C for 24 hours, take it out, grind it into powder, pass it through a 60-mesh sieve, add more than 80% ethanol according to the solid-liquid ratio of 1:5, extract at 60°C for 2 hours, and filter the extract. The filter residue was extracted twice according to the above method, and the filtrates were combined and dried under reduced pressure to obtain the extract concentrate of kelp root.

[0032] Add 5 times the amount of ethyl acetate and 0.1% vitamin C to the extract concentrate obtained from kelp root, stir and extract at room temperature for 24 hours, siphon the upper layer solution, and extract the lower layer precipitation twice with the same method, combine the extracts, reduce Press and dry to obtain the kelp root hypoglycemic product B.

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Abstract

The invention relates to a laminaria japonica root hypoglycemic product and a preparation method and application thereof. The preparation method comprises the following steps that laminaria japonica roots are taken and extracted for multiple times through ethyl alcohol, an antioxidant is added during the extraction process, and an extracted concentrate is obtained; and extract liquor is added into the extracted concentrate for extraction, an antioxidant is added in the extraction process, drying is conducted, and the laminaria japonica root hypoglycemic product is obtained. The laminaria japonica roots used in the preparation method is sufficient in raw material, and the laminaria japonica root hypoglycemic product is definite in hypoglycemic effect and free of toxic and side effects, and is a safe and effective hypoglycemic product; the hypoglycemic product obtained through the preparation method has an obvious inhibition effect on alpha-glucosidase, reaches 140 [mu]g / ml in IC50, and is a noncompetitive inhibitor to the alpha-glucosidase; and an antioxidant vitamin C is added, compared with the prior art, the hypoglycemic effect IC50 is doubled or above, and meanwhile, the product yield is increased by several times.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a kelp root hypoglycemic product and a preparation method and application thereof. Background technique [0002] Diabetes is a major disease that seriously endangers human health. It has many and serious complications and is difficult to cure. There are tens of millions of diabetic patients in my country, which is one of the countries with the largest number of diabetic patients in the world. Currently, clinically used drugs for the treatment of diabetes include sulfonylureas and biguanides. However, long-term use of these drugs has serious side effects. For example, sulfonylureas have adverse reactions of hypoglycemia; biguanides have gastrointestinal side effects. Insulin replacement drugs are relatively safe and effective drugs at this stage, but they are expensive and have restrictions on storage conditions. Therefore, it is of great significance to look for hypoglycemic products th...

Claims

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Application Information

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IPC IPC(8): A61K36/03A61P3/10
Inventor 林秀坤耿元生孙文昌杨增光姜玉宝
Owner QINGDAO JIARILONG SEAFOOD
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