Anti-infection application of thiazole-structure-containing compound
A compound and application technology, which is applied in the field of anti-infection application of compounds containing thiazole structures, can solve problems such as easy drug resistance and high pressure for bacterial survival
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Embodiment 1
[0176] Synthesis of Example 1.1 Compound ML364 (2-((4-methylphenyl)sulfonylamino)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide) References: Mindyl I. Davis et al., Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclinD1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and MantleCell Lymphoma Models, THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL.291, NO.47, pp. 24628–24640, November 18, 2016. The compounds in Table 1 can be synthesized in a similar manner.
Embodiment 12
[0177] Example 1.2 Synthesis of compound 2-((4-fluorophenyl)sulfonylamino)-N-(4-(4-isopropylphenyl)thiazol-2-yl)benzamide: same as in Example 1.1 method to synthesize the target compound.
[0178]
Embodiment 13
[0179] Synthesis of Example 1.3 Compound 2-((4-fluorophenyl)sulfonylamino)-N-(4-(4-methylphenyl)thiazol-2-yl)benzamide: obtained in Example 1.2 Intermediate 5 and Intermediate 6 were obtained in the same way as the target compound.
[0180]
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