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Pyrimidine compound with effect of adhesion kinase inhibition and preparation method and application thereof

A compound and pyrimidine technology, applied in the field of pyrimidine derivatives, can solve the problems of difficulty in providing diagnostic information, false positives, poor specificity, etc.

Inactive Publication Date: 2015-04-29
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the commonly used inspection methods for the diagnosis of malignant tumors have certain limitations, or have false positives, or have poor specificity, or low sensitivity; B-ultrasound, CT, and nuclear magnetic resonance are based on the morphological changes of the disease, and it is difficult to detect them in the early stage of cancer. Provides diagnostic information in the absence of structural morphological changes

Method used

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  • Pyrimidine compound with effect of adhesion kinase inhibition and preparation method and application thereof
  • Pyrimidine compound with effect of adhesion kinase inhibition and preparation method and application thereof
  • Pyrimidine compound with effect of adhesion kinase inhibition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The synthesis of compound 1, the synthetic route is as follows:

[0077]

[0078] Specific steps include:

[0079] 1.5g (10mmol) 2-chloro-7H-pyrrole[2,3-d]pyrimidine, 3g anhydrous potassium phosphate, a small amount of CuI and trans-1,2-cyclohexanediamine and 10ml dioxane were added to In the there-necked flask, then slowly add 3.2g (12mmol) 3-bromobenzophenone, at 110°C, N 2 Stirring and reflux under protection for 5h. The reaction was detected with a thin-layer chromatographic plate, the reaction was completed, the solid was filtered, and the solid was washed 3 times with a small amount of dioxane, and then saturated NaHCO was added. 3 Solution, the organic phase was washed with 3×10mL saturated brine, dried with anhydrous MgSO4, filtered, spin-dried dioxane, and passed through a silica gel column with a developer ethyl acetate:petroleum ether=1:10-1:2, and finally A pale white solid A was obtained with a yield of 75.5%. Add 300mg of compound A, 600mg of p-brom...

Embodiment 2

[0081] The synthesis of compound 2, the synthetic route is as follows:

[0082]

[0083] Concrete synthetic steps include:

[0084] Add 3.5g of 2,5-dibromobenzoic acid and 20ml of methanol into a 100ml single-necked bottle, stir at room temperature and slowly add 10ml of concentrated sulfuric acid, stir for 10 minutes after adding the concentrated sulfuric acid and start heating to reflux, react for 8 hours, and detect the reaction with a thin-layer chromatography plate. After the reaction, excess methanol was spun to dry, 50ml of water was added, and filtered to obtain a white solid with a yield greater than 85%. 1.5g (10mmol) 2-chloro-7H-pyrrole[2,3-d]pyrimidine, 3g anhydrous potassium phosphate, a small amount of CuI and trans-1,2-cyclohexanediamine and 10ml dioxane were added to In the three-necked flask, add 3.0 g of methyl 2,5-dibromobenzoate, and stir and reflux at 110° C. for 6 h. The reaction was detected with a thin-layer chromatographic plate, the reaction was ...

Embodiment 3

[0086] The synthesis of compound 3, the synthetic route is as follows:

[0087]

[0088] Concrete synthetic steps include:

[0089] 1.5g (10mmol) 2-chloro-7H-pyrrole[2,3-d]pyrimidine, 3g anhydrous potassium phosphate, a small amount of CuI and trans-1,2-cyclohexanediamine and 10ml dioxane were added to Then slowly add 4.5g of 2,5-dibromopyridine into the three-neck flask, and stir and reflux at 110°C for 5h. The reaction was detected with a thin-layer chromatographic plate, the reaction was completed, the solid was filtered, and the solid was washed 3 times with a small amount of dioxane, and then saturated NaHCO was added. 3 solution, the organic phase was washed with 3×10mL saturated brine, dried with anhydrous MgSO4, filtered, spin-dried dioxane, and passed through a silica gel column with a developer ethyl acetate:petroleum ether=1:10-1:2, and finally 950mg of pale white solid was obtained. Add 300mg of compound C, 600mg of anisidine, 3ml of concentrated hydrochloric...

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PUM

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Abstract

The invention provides a pyrimidine compound, and the structure of the pyrimidine compound is shown in the following formulas (I) and (II), wherein R is substituted phenyl or substituted pyridyl; R1 is -NO2, -Br, -COOH or -OCH3; n is an integer of 1-3; X is -Br or CI; and R8, R9 and R10 are identical or different -H, -OCH3, -COOMe, -Br, -COOEt, -CH2COOMe, -NO2 or (CH2)1-4OH. The pyrimidine compound provided by the invention has an effect of FAK inhibition, can effectively enter tumor cells, has a good effect of inhibiting the tumor cells and can be better detained. The invention also provides a preparation method of the compound and the application of the compound to the preparation of preparing a tumor inhibitor.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry, specifically to the field of radiopharmaceutical chemistry, in particular to a series of pyrimidine derivatives with focal adhesion kinase inhibitory effect. Background technique [0002] Focal Adhesion Kinase (FAK) is a non-receptor tyrosine protein kinase [1] , was identified in 1992 as a highly phosphorylated protein associated with the oncogene v-src, located in integrin-rich focal adhesion regions of normal cells. FAK is an important cytoskeletal protein and a key molecule of various signaling pathways in cells, and plays an important role in cell survival, proliferation, migration and invasion [2-7] . FAK plays a very important role in the occurrence and development of tumors, so it may be used as a marker molecule for tumor invasion and prognosis of malignant tumors, and FAK may become an effective target for tumor treatment and may become a tumor diagnosis and new targets for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D487/04C07D239/48A61K31/519A61K31/505A61P35/00
Inventor 张华北赵凌舟卢霞薛甜
Owner BEIJING NORMAL UNIVERSITY
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