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Novel application of ginsenoside Rd in preparing drug for preventing and/or treating microglial cell mediated diseases

A technology of microglia and ginsenosides, which can be used in drug combinations, muscular system diseases, nervous system diseases, etc., can solve the problems of no report of public ginsenoside Rd, no report of ginsenoside Rd microglia immunotoxicity, etc. , to achieve significant effect and high safety effect

Inactive Publication Date: 2015-10-07
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is currently no literature reporting that ginsenoside Rd can inhibit microglia-related immunotoxicity, nor has it been reported that ginsenoside Rd can prevent and treat diseases such as amyotrophic lateral sclerosis, AIDS-related dementia, and mad cow disease.

Method used

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  • Novel application of ginsenoside Rd in preparing drug for preventing and/or treating microglial cell mediated diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of ginsenoside Rd

[0032] 1) Extract the Radix Notoginseng medicinal material with water, and concentrate the extract into a Radix Notoginseng extract containing 25% solids;

[0033] 2) After the Panax notoginseng extract is degreased, it is purified by D-type macroporous resin, washed with water: 95% ethanol according to the gradient elution method to remove triol glycoside components and most diol glycoside components outside Rd, and then separately with 70 % ethanol elutes the saponins mainly composed of ginsenoside Rd, collects the eluate and decolorizes it, recovers the solvent, concentrates it, and dries it under reduced pressure to make a dry product;

[0034] 3) The dry product was dissolved in 95.0% ethanol, and the insoluble matter was filtered out with a 50 μm filter membrane, and then absorbed by a monodisperse polymeric silica gel chromatography column, eluted and purified by gradient elution with water and 95.0% ethanol, and ...

Embodiment 2

[0036] Embodiment 2: the preparation of ginsenoside Rd

[0037] 1) Take ginseng and extract with ethanol with a concentration of 25%, recover the ethanol from the extract to obtain a Panax notoginseng extract containing 20% ​​solids;

[0038] 2) After the ginseng extract is degreased, it is purified by D-type macroporous resin, washed with water: 95% ethanol according to the gradient elution method to remove the triol glycoside components and most of the diol glycoside components outside Rd, and then separately with 95% ethanol Ethanol elutes the saponins mainly composed of ginsenoside Rd, collects the eluate and decolorizes it, recovers the solvent, concentrates it, and dries it under reduced pressure to make a dry product;

[0039] 3) The dried product was dissolved in 96% ethanol, and the insoluble matter was filtered out with a 45 μm filter membrane, and then absorbed by a monodisperse polymeric silica gel chromatography column, eluted and purified by gradient elution with...

Embodiment 3

[0041] Embodiment 3: the preparation of ginsenoside Rd

[0042] 1) Extract the Radix Notoginseng medical material with 96% ethanol, recycle the ethanol from the extract to obtain a Radix Notoginseng extract containing 5% solids;

[0043]2) After the Panax notoginseng extract is degreased, it is purified by D-type macroporous resin, washed with water: 95% ethanol according to the gradient elution method to remove the triol glycoside components and most of the diol glycoside components outside Rd, and then separately with 95 % ethanol solution to elute the saponins mainly composed of ginsenoside Rd, collect the eluent and decolorize it, recover the solvent, concentrate, dry under reduced pressure, and make a dry product;

[0044] 3) The dried product was dissolved in 98.0% ethanol, and the insoluble matter was filtered out with a 1 μm filter membrane, and then absorbed by a monodisperse polymeric silica gel chromatography column, eluted and purified by gradient elution with wate...

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Abstract

The invention relates to a novel application of ginsenoside Rd in preparing a drug for treating microglial cell mediated diseases, and particularly relates to a novel application of ginsenoside Rd in preparing a drug for treating diseases such as disseminated sclerosis, amyotrophic lateral sclerosis, HIV-associated dementia, mad cow disease and the like.

Description

technical field [0001] The present invention relates to a new application of ginsenoside Rd, that is, a new application in the preparation of drugs for preventing and / or treating diseases mediated by microglial cells. Background technique [0002] Abnormal activation of microglia plays an important role in multiple sclerosis and other diseases, and is one of the main causes of nerve damage in the pathological development of the above diseases. Under pathological conditions, small changes in the microenvironment can activate microglia, and the activated microglia can up-regulate the secretion levels of many neurotoxic factors, such as nitric oxide (NO), reactive oxygen species (ROS) and peanut-like Acids (such as prostaglandin E2), etc., leading to secondary brain damage. Therefore, inhibiting the excessive activation of microglia can effectively prevent and treat diseases such as multiple sclerosis and multiple sclerosis. [0003] Ginsenoside Rd (Ginsenoside Rd, molecular ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P25/28A61P21/00A61P43/00
Inventor 许淑清王少峡黄宇声胡利民李钊文郭虹刘冠萍孟凡英郑志远张栩颜
Owner GUANGXI WUZHOU PHARMA GRP
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