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A pharmaceutical composition with anti-dysmenorrhea effect and preparation method thereof

The technology of a composition and medicine is applied in the field of pharmaceutical compositions with anti-dysmenorrhea effect and the preparation field thereof, which can solve the problems such as unclear effect substances, and achieve the effect of enhancing the anti-dysmenorrhea activity

Inactive Publication Date: 2018-01-05
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, the effect component is the material basis of traditional Chinese medicine for disease prevention and treatment. However, in the research report of Cyperus cyperi, only research shows that α-cyperone is one of the active components of Cyperus cyperus to exert antipyretic and analgesic effects, and other effect substances still unclear

Method used

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  • A pharmaceutical composition with anti-dysmenorrhea effect and preparation method thereof
  • A pharmaceutical composition with anti-dysmenorrhea effect and preparation method thereof
  • A pharmaceutical composition with anti-dysmenorrhea effect and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0023] The specific steps of the preparation method of the pharmaceutical composition with anti-dysmenorrhea effect of the present invention are as follows:

[0024] (1) Extraction of monomer compound components:

[0025] Crush Cyperus cyperi from Jianchangbang Sizhi into a coarse powder, place it in a round bottom flask, add 95% ethanol in an amount 8 times the amount of Cyperus cyperus from Jianchangbang, heat and reflux for extraction 3 times, each time for 2 hours, combine the filtrates, and The organic solvent in the filtrate is recovered under reduced pressure to obtain the Cyperus cyperi extract;

[0026] (2) Separation and purification of monomer compound components:

[0027] The extract of Cyperus cyperi is extracted by petroleum ether, the type of petroleum ether is 60-90°C, and the petroleum ether part of Cyperus cyperi is obtained; the petroleum ether part of Cyperus cyperi is mixed with 1-2 times of silica gel, and evaporated to dryness After the solvent, put it...

Embodiment 2

[0031] The specific steps of the preparation method of the pharmaceutical composition with anti-dysmenorrhea effect of the present invention are as follows:

[0032] (1) Extraction of monomer compound components:

[0033] Crush Cyperus cyperi from Jianchangbang Sizhi into a coarse powder, place it in a round bottom flask, add 95% ethanol in an amount 8 times the amount of Cyperus cyperus from Jianchangbang, heat and reflux for extraction 3 times, each time for 2 hours, combine the filtrates, and The organic solvent in the filtrate is recovered under reduced pressure to obtain the Cyperus cyperi extract;

[0034] (2) Separation and purification of monomer compound components:

[0035] The extract of Cyperus cyperi is extracted with petroleum ether (60-90°C) to obtain the petroleum ether part of Cyperus cyperi; mix the petroleum ether part of Cyperus cyperi with 1-2 times the amount of silica gel, evaporate the solvent, and dry Put the method on a silica gel column, use petrol...

Embodiment 3

[0039] The specific steps of the preparation method of the pharmaceutical composition with anti-dysmenorrhea effect of the present invention are as follows:

[0040] (1) Extraction of monomer compound components:

[0041] Crush Cyperus cyperi from Jianchangbang Sizhi into a coarse powder, place it in a round bottom flask, add 95% ethanol in an amount 8 times the amount of Cyperus cyperus from Jianchangbang, heat and reflux for extraction 3 times, each time for 2 hours, combine the filtrates, and The organic solvent in the filtrate is recovered under reduced pressure to obtain the Cyperus cyperi extract;

[0042] (2) Separation and purification of monomer compound components:

[0043] The extract of Cyperus cyperi is extracted with petroleum ether (60-90°C) to obtain the petroleum ether part of Cyperus cyperi; mix the petroleum ether part of Cyperus cyperi with 1-2 times the amount of silica gel, evaporate the solvent, and dry Put the method on a silica gel column, use petrol...

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Abstract

The invention discloses a pharmaceutical composition with antimenorrhea effect and a preparation method thereof. The pharmaceutical composition is composed of three effect components, namely cyperenone, α-cyperone and sugeonol. When the three kinds of effective compounds were compared with the anti-dysmenorrhea biological effect experiment with pharmaceutical compositions of different proportions, the results showed that: when the mass ratio of cyperenone, α-cyperone and sugeonol was 43:41:16, its anti-dysmenorrhea The efficacy is significantly enhanced. The present invention has the following advantages: the pharmaceutical composition is the best composition of active ingredients of Cyperus cyperi for anti-dysmenorrhea effect, and from the perspective of active ingredients, the ratio of active ingredients is studied, so that the anti-dysmenorrhea effect of Cyperus cyperi can be improved. The biological effect is greatly improved. The compatibility of active ingredients of traditional Chinese medicine eliminates the interference of non-effective substances, which is conducive to the discovery of new components of traditional Chinese medicine, the development of various effective preparations for clinical application, and the research of new dosage forms.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition with anti-dysmenorrhea effect and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to periodic lower abdominal pain or lumbosacral pain during menstruation or before and after menstruation, accompanied by pale complexion, cold hands and feet, nausea and vomiting, and cold sweats. Clinically, there are mainly two kinds of primary dysmenorrhea and secondary dysmenorrhea. Primary dysmenorrhea has no obvious abnormalities in the reproductive organs, while secondary dysmenorrhea is mostly manifested as certain organic lesions of the reproductive organs. The incidence of dysmenorrhea is relatively high, about 42% to 90%, of which severe dysmenorrhea accounts for 18%, and it is more common in young women. It is one of the key diseases treated by TCM gynecology. [0003] The active ingredients of traditio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61P15/00A61P29/00
Inventor 郭慧玲胡律江赵晓娟胡志方许茜茜
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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