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Preparation method of Antike capsules

A technology of capsule and toad skin is applied in the field of preparation of Antico capsules, which can solve the problems of increased dosage and frequency of taking medicine, instability, fluctuation of ferulic acid content, etc., and achieves reduction of dosage, reduction of capsules, and reduction of capsule size. Effect

Inactive Publication Date: 2015-11-11
长春雷允上药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the simple treatment of angelica medicinal materials and toad skin medicinal materials in such a preparation process, the content of active ingredients cinobufagin, esterbufagenin and ferulic acid in Antico capsules fluctuates or is unstable, and these active ingredients cannot be Sufficient absorption by patients increases the dose and frequency of medication taken by patients, which limits the wide clinical application of Antico Capsules

Method used

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  • Preparation method of Antike capsules
  • Preparation method of Antike capsules
  • Preparation method of Antike capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Chinese medicine extraction

[0039] 1. Angelica Extract

[0040] Take Chinese angelica coarse powder and add 50% to 95% ethanol aqueous solution for reflux extraction, the volume of ethanol aqueous solution added in ml:g is 3 to 7 times the mass of angelica coarse powder, reflux for 0.5 to 3.0 hours, filter, and take clear liquid , Concentrate under reduced pressure at 45-55°C to a thick paste, recover ethanol until it is odorless, dry, and obtain an extract for future use.

[0041] 2. Toad Skin Extraction

[0042] Take the coarse powder of toad skin, add water whose mass is 8-16 times the mass of the coarse powder of toad skin, decoct for 20-70 minutes, filter, cool to below 40°C, concentrate into a dry extract, and set aside.

Embodiment 2

[0043] Example 2 Chinese medicine extraction

[0044] 1. Angelica Extract

[0045] Take Chinese angelica coarse powder and add 60-80% ethanol aqueous solution to reflux and extract twice, the volume of the ethanol aqueous solution added each time is 4-6 times of the quality of angelica coarse powder, reflux for 1.0-2.0 hours, filter, take clear liquid, in Concentrate under reduced pressure at 45-55°C to a thick paste, recover ethanol until it is odorless, dry, and obtain an extract for future use.

[0046] 2. Toad Skin Extraction

[0047] Take the coarse powder of toad skin, soak in water for 0.5-3 hours, add water with a mass 10-15 times the mass of the coarse powder of toad skin, decoct for 30-60 minutes, filter, add 5-10 times the amount of water, and then decocted for 10-50 minutes, combined the second decoction liquid, filtered, cooled to below 40°C, concentrated into a dry extract, and set aside.

Embodiment 3

[0048] Example 3 Chinese medicine extraction

[0049] 1. Angelica Extract

[0050]Take Chinese angelica coarse powder and add 65% ethanol aqueous solution to reflux and extract twice, the volume of ethanol aqueous solution added each time is 4 times the volume of angelica coarse powder, reflux for 1.0 hour, filter, take clear liquid, and concentrate under reduced pressure at 45-55°C To a thick paste, recover ethanol until it is odorless, dry, and obtain the extract of Angelica sinensis for later use.

[0051] 2. Toad Skin Extraction

[0052] Take the coarse powder of toad skin, soak in water for 1.5 hours, add water with a volume that is 14 times the quality of the coarse powder of toad skin, decoct for 30 minutes, filter, add 6 times the amount of water to the dregs, and decoct for 15 minutes. Combine the second decoction liquid, filter, cool to below 40°C, concentrate into toad skin dry extract, and set aside.

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Abstract

The invention provides a preparation method of Antike capsules. The method comprises the following steps: 1, carrying out refluxing extraction on a Chinese angelica raw material by using an ethanol-water solution, filtering, taking the obtained clear liquid, and concentrating to obtain Chinese angelica extract, wherein the Chinese angelica raw material preferably adopts coarse Chinese angelica powder; 2, decocting a toad skin raw material in water, and filtering to obtain dry toad skin extract, wherein the toad skin raw material preferably adopts coarse toad skin powder; 3, mixing the Chinese angelica extract obtained in step 1 with the dry toad skin extract obtained in step 2 according to a mass ratio of 0.8-2.3, adding a wetting agent, and uniformly mixing; and 4, granulating, finishing, drying, and filling capsules to obtain the Antike capsules. Effective components of raw medicinal materials are extracted through the method, so few contents in the capsules under a same content requirement are met, thereby the capsules are shrunk, patient deglutition is facilitated, and especially esophageal cancer patients are benefited.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine compound preparation, in particular to a preparation method of Antico capsule. Background technique [0002] Antico Capsule is a traditional Chinese medicine compound preparation made from angelica and toad skin. For esophageal cancer stasis, combined with radiotherapy can enhance the curative effect on esophageal cancer, gastric cancer and liver cancer, and can improve the clinical symptoms and quality of life of patients. [0003] Toad skin is the dry skin of Bufobufogargarizans Cantor or Bufomelanostictus Schneider, which has the functions of clearing away heat and detoxifying, diuresis and reducing swelling. The content of active ingredients is very important for the curative effect of Antico capsules. There are about ten kinds of active components of toad venom contained in toad skin, mainly bufogenins and its lipids (called bufotoxins), and its main chemical componen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K36/232A61P35/00A61K35/65
Inventor 邵春杰
Owner 长春雷允上药业有限公司
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