The invention provides a preparation method of Antike capsules. The method comprises the following steps: 1, carrying out refluxing extraction on a Chinese angelica raw material by using an ethanol-water solution, filtering, taking the obtained clear liquid, and concentrating to obtain Chinese angelica extract, wherein the Chinese angelica raw material preferably adopts coarse Chinese angelica powder; 2, decocting a toad skin raw material in water, and filtering to obtain dry toad skin extract, wherein the toad skin raw material preferably adopts coarse toad skin powder; 3, mixing the Chinese angelica extract obtained in step 1 with the dry toad skin extract obtained in step 2 according to a mass ratio of 0.8-2.3, adding a wetting agent, and uniformly mixing; and 4, granulating, finishing, drying, and filling capsules to obtain the Antike capsules. Effective components of raw medicinal materials are extracted through the method, so few contents in the capsules under a same content requirement are met, thereby the capsules are shrunk, patient deglutition is facilitated, and especially esophageal cancer patients are benefited.