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Lactobacillus plantarum ZS2058 and application thereof

A technology of ZS2058 and Lactobacillus plantarum, applied in the field of microorganisms, can solve problems such as large side effects, difficult long-term treatment of IBD, affecting quality of life and physical health

Inactive Publication Date: 2015-12-02
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] IBD seriously affects people's quality of life and health, and consumes health resources
At present, the treatment drugs for IBD include antibiotics, aminosalicylic acid, glucocorticoids, immunosuppressants (6-MP, AZA, MTX) and biological agents (infliximab), etc., but the side effects are large, and it is difficult to achieve long-term treatment of IBD, such as biological agents The preparation infliximab is a TNF-α monoclonal antibody, which can effectively achieve the therapeutic goal of IBD, but the common adverse reactions of infliximab include infection, congestive heart failure, autoimmune reaction, nervous system disease, liver damage, malignant tumor, etc.

Method used

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  • Lactobacillus plantarum ZS2058 and application thereof
  • Lactobacillus plantarum ZS2058 and application thereof
  • Lactobacillus plantarum ZS2058 and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1: Lactobacillus plantarum ZS2058 improves the animal experiment of colitis induced by DSS

[0070] The specific experiment is as follows:

[0071] 1. Experimental animals

[0072] Twenty-four SPF grade male C57BL / 6J mice aged 6-8 weeks were purchased from Suzhou Supusi Biotechnology Co., Ltd. and raised under the conditions of temperature 22±2°C, free access to food and water, and 12 hours of day and night alternation. The feed used was the mouse breeding compound feed produced by Suzhou Shuangshi Experimental Animal Feed Technology Co., Ltd., and the experiment was carried out after a week of adaptation to a normal diet.

[0073] 2. Culture of Lactobacillus plantarum ZS2058

[0074] The Lactobacillus plantarum ZS2058 cells were streaked on the solid MRS plate, and a single colony was picked and cultured in the liquid MRS medium for 12 hours. After two generations, it was used for subsequent experiments.

[0075] The activated Lactobacillus plantarum ZS20...

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Abstract

The invention relates to lactobacillus plantarum ZS2058 and application thereof. The lactobacillus plantarum ZS2058 and the application have the advantages that colitis symptoms of diarrhea, stool occult blood, hematochezia and the like of mice can be effectively improved by the lactobacillus plantarum ZS2058, increase of disease activity indexes (DAI) can be suppressed, change of the lengths of colons of the mice can be improved, the activity of myeloperoxidase (MPO) can be obviously reduced, and the lactobacillus plantarum ZS2058 can be used for preparing medicine for preventing and treating intestinal inflammation or producing food beneficial to the intestinal health.

Description

【Technical field】 [0001] The invention belongs to the technical field of microorganisms. More specifically, the present invention relates to a plant Lactobacillus (Lactobacillus plantarum) ZS2058, and the present invention also relates to the use of the plant Lactobacillus. 【Background technique】 [0002] Inflammatory bowel disease (Inflammatory Bowel Disease, IBD) is a group of chronic, relapsing intestinal inflammatory diseases, divided into ulcerative colitis (Ulcerative Colitis, UC) and Crohn's disease (Crohn's Disease, CD), the pathogenesis is not yet clear clear. However, according to the current research on the pathogenesis of IBD, it is generally believed that IBD may be related to four factors: susceptibility genes, mucosal immunity, intestinal microorganisms and environment, and mucosal immunity plays an important role in the pathogenesis of IBD. The disease is distributed worldwide. In recent years, with the improvement of people's living standards and changes ...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P1/00
Inventor 陈卫陈海琴王俊通杨波杨芹田丰伟赵建新张灏陈永泉
Owner JIANGNAN UNIV
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