Application of Lichang Decoction in Preparation of Drugs for Crohn's Disease
A technology for Crohn's disease and intestinal regulation, applied in the field of biomedicine, can solve problems such as excessive adverse reactions, easy recurrence, and high tolerance rate
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[0025] When the intestine-reducing soup base is used to prepare granules, the auxiliary materials are preferably sucrose powder and dextrin. The preparation method of the granule-form medicine for treating Crohn's disease is preferably: decocting the raw materials of Lichang Decoction to obtain a filtrate, refining the filtrate to obtain a clear ointment, mixing the clear ointment and auxiliary materials evenly, granulating and drying to obtain a granule. In the present invention, the decocting is preferably performed twice, and the time for each decoction is preferably 2 hours. The refinement preferably sequentially includes: concentrating the filtrate, extracting the supernatant, and concentrating the supernatant to obtain a clear paste. During the concentration, the present invention preferably concentrates the relative density of the filtrate to 1.25-1.30 (80° C.). The extraction supernatant is specifically preferably as follows: add 1500ml of ethanol to the concentrated ...
Embodiment 1
[0032] Codonopsis 30g, Stir-fried Atractylodes macrocephala 15g, Myrobalan 15g, Chishizhi 30g (fried), Sophora japonica 15g, Raw Puhuang 15g (fried), Bletilla striata 15g, Toon root bark 30g, Coix seed 30g, Panax notoginseng slices 10g, Xu Changqing 30g, licorice slices 10g.
[0033]Soak the above raw materials in 1225mL of distilled water for 30min, decoct with strong fire until boiling, then decoct with slow fire for 30-40min, filter out the filtrate; add 700mL of water to the medicinal dregs, repeat the above steps, decoct again, and filter. After combining the two filtrates, heat and stir until well mixed. Pipette 84 mL of the above Lichang Decoction into a 10 mL centrifuge tube, centrifuge at 12000 rpm / min at 4°C for 10 min, and then use a rotary evaporator to concentrate the solution to 0.55 g / mL, 1.1 g / mL and 2.2 g / mL respectively.
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