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A traditional Chinese medicine composition for treating ulcerative colitis and its preparation method and application

A technology for ulcerative colitis and a composition is applied in the field of traditional Chinese medicine composition for treating ulcerative colitis and its preparation field, which can solve the problems of high recurrence rate, toxic and side effects, unsatisfactory treatment effect and the like, and achieves reduction of MPO content and curative effect. Significantly improve the effect of blood in the stool of animals

Active Publication Date: 2020-04-07
和光中药科技(天津)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have played a positive role in the treatment of UC, but at the same time there are problems such as high recurrence rate, unsatisfactory treatment effect and serious side effects.

Method used

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  • A traditional Chinese medicine composition for treating ulcerative colitis and its preparation method and application
  • A traditional Chinese medicine composition for treating ulcerative colitis and its preparation method and application
  • A traditional Chinese medicine composition for treating ulcerative colitis and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0051] Take 200g of Codonopsis pilosula, 100g of Sophora flavescens, 100g of woody fragrance, 120g of myrobalan meat, and 80g of Alisma alisma, add water to decoct twice, the weight of adding water for the first time is 10 times the total weight of raw materials, decoct for 2 hours, and decoct for the second time The weight of adding water is 8 times of the total weight of the raw materials, decocting for 1.5 hours, combining the decoction liquid, filtering, and concentrating the filtrate to a clear paste with a relative density of 1.10-1.25 (60°C). Take clear paste, dry (60°C), pulverize to obtain dry powder, weigh 180g of dry powder, add 100g of sodium carboxymethyl starch, 90g of microcrystalline cellulose, 60g of lactose, 20g of micropowder silica gel, fully stir and mix to form granules, and Dry at 60-70°C for 2-4 hours and press into 1000 pieces.

Embodiment 2

[0053] Take 100g of Codonopsis pilosula, 200g of Sophora flavescens, 20g of woody fragrance, 180g of Myrobalan meat, 100g of Alisma alisma, add water to decoct twice, the weight of water added for the first time is 6 times the total weight of raw materials, decoct for 1 hour, and the second time The weight of adding water is 12 times of the total weight of raw materials, decocting for 3 hours, combining the decoction liquid, filtering, the filtrate is concentrated to a clear paste with a relative density of 1.18-1.23 (60°C), and adding ethanol to make the alcohol content reach 65% v / v, stir evenly, let stand for 24 hours, filter, and recover ethanol from the filtrate under reduced pressure and concentrate to a clear paste with a relative density of 1.10-1.25 (60°C). Take clear paste, dry (60°C), pulverize to obtain dry powder, weigh 130g dry powder, add 100g sodium carboxymethyl starch, 80g microcrystalline cellulose, 70g lactose, 10g magnesium stearate, fully stir and mix to m...

Embodiment 3

[0055] Get 300g of Codonopsis pilosula, 20g of Sophora flavescens, 200g of woody fragrance, 60g of myrobalan meat, 20g of Alisma alisma, add 60% v / v ethanol aqueous solution to reflux and extract twice, the weight of the ethanol aqueous solution that adds for the first time is 10% of the total weight of raw materials Double the amount, heat for 2 hours, the weight of the ethanol aqueous solution added for the second time is 8 times the total weight of the raw material, heat for 1.5 hours, combine the extracts, filter, and concentrate the filtrate to a relative density of 1.10-1.25 (60 ° C) clear ointment. Take clear paste, dry (60°C), pulverize to obtain dry powder, weigh 195g of dry powder, add sodium carboxymethyl starch 100g, microcrystalline cellulose 40g, lactose 45g, talcum powder 10g, fully stir and mix to make granules, Dry at 60-70°C for 2-4 hours and press into 1000 tablets.

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Abstract

The invention provides a novel Chinese medicine composition for treating ulcerative colitis and a preparation method thereof. The composition is mainly prepared from the following raw materials including, by weight, 5-15 parts of codonopsis pilosula, 1-10 parts of radix sophorae flavescentis, 1-10 parts of costustoot, 3-9 parts of myrobalan meat and 1-8 parts of salt oriental waterplantain rhizome. The preparation method of the Chinese medicine composition comprises the following steps that all the raw materials are taken by weight; water is added for decoction, or extraction is conducted through ethanol water, and a decoction solution or an extraction solution is obtained; the obtained decoction solution or the obtained extraction solution is filtered, so that filtrate is obtained; and the filtrate is subjected to concentration, so that clear paste is obtained. The invention further provides application of the Chinese medicine composition in preparing medicine for treating inflammation. Rat colon tissue pathological damage caused by trinitro-benzene-sulfonic acid can be antagonized through the Chinese medicine composition, the overall inflammatory immune reaction can be reinforced, appearance signs such as animal hemafecia, diarrhea, little activity and the like are obviously improved, and the curative effect is obvious.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating ulcerative colitis, a preparation method and application thereof. Background technique [0002] Ulcerative colitis (Ulcerative Colitis, UC) is an autoimmune chronic inflammatory disease and ulcerative lesion of the rectum and colon. Recurrence, protracted up to decades, and the risk of cancer, brought great pain and threat to patients. In recent years, with the development of my country's economy, great changes have taken place in people's diet structure and lifestyle. According to relevant hospitalized cases and clinical literature, the incidence of UC is on the rise. focus of attention. [0003] At present, based on the understanding of the etiology and pathogenesis of UC, modern medicine mainly adopts anti-inflammatory, antibacterial, and immune response suppression methods. Commonly used drugs inc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61P1/00A61P1/04
Inventor 周福军王淼单淇华洁侯文彬
Owner 和光中药科技(天津)有限公司
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