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Use of acalypha copperleaf water extract in preparing medicine for treating chronic ulcerative colitis

A water extract, chronic ulcer technology, applied in the field of medicine

Inactive Publication Date: 2007-05-23
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no report about the water extract of amaranth for the treatment of chronic ulcerative colitis

Method used

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  • Use of acalypha copperleaf water extract in preparing medicine for treating chronic ulcerative colitis
  • Use of acalypha copperleaf water extract in preparing medicine for treating chronic ulcerative colitis
  • Use of acalypha copperleaf water extract in preparing medicine for treating chronic ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 Now in conjunction with embodiment, the present invention is described in detail

[0012] Preparation of the water extract of Amaranth amaranthus: crush the dried pieces of Amaranth amaranth into coarse powder, add 10 times the amount of distilled water, decoct twice, each time for 1 hour, combine the decoction liquid, concentrate under reduced pressure in a rotary evaporator, and finally A concentrate of 1 g crude drug / ml was obtained.

Embodiment 2

[0013] Example 2 Therapeutic effect of water extract of amaranth on diarrhea, blood in stool, weight loss and colonic morphological changes in UC model rats.

[0014] 1. Animals: 60 clean-grade, healthy male SD rats, weighing 180g-200g, purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences, animal certificate number: [SYXK (Shanghai) 2002-0026]. Sixty rats were randomly divided into 6 groups, 10 rats in each group, one of which was used as the normal control group, and the remaining 5 groups were used for modeling.

[0015] 2. Preparation of UC animal model: Morris method (Morris GP, Beck PL, Herridge MS, et al. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology1989, 96(3), 795-803.) To make the model, take the above-mentioned healthy male SD rats, fasting for 24 hours, injecting 2% pentobarbital sodium into the abdominal cavity for light anesthesia, and gently inserting a latex tube with a diameter of 2 mm ...

Embodiment 3

[0038] Example 3 Antioxidation and Anti-NO Free Radical Effects of Amaranth Water Extract

[0039] 1. Animals: healthy male SD rats, weighing 180--200g

[0040] 2. Drugs: Amaranth water extract is the test drug; SASP is the treatment control drug

[0041] 3. Animal grouping and administration: the animals were randomly divided into four groups, with 10 animals in each group. One group was randomly selected as the normal control group, and the other three groups were modeled with TNBS (the same method as before).

[0042] Group 1 is the normal control group: intragastric administration of normal saline every day.

[0043] The second group is the model control group: intragastric administration of normal saline every day.

[0044] The third group is the middle dose group of the water extract of amaranth: 6.5 g crude drug / kg body weight of the water extract of amaranth is gavaged every day.

[0045] Group 4 is the positive control group: 0.3 g / kg body weight of SASP suspensio...

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Abstract

The present invention relates to medicine technology, and is the new use of water extract of acalypha copperleaf as a kind of euphorbiaceae plant in preparing medicine for treating chronic ulcer colonitis. Animal test shows that water extract of acalypha copperleaf can improve effectively the symptoms, including diarrhea, hemafecia, losing weight, colon tissue form change, etc. of ulcer colonitits rat model; and can eliminate neutral granulocyte. Biochemical detection and molecular biological test proves its antioxidant and anti-NO free radical effect, and the function of inhibiting the expression of inducing NO syntase in the RNA level. Therefore, water extract of acalypha copperleaf may be used in preparing medicine for treating chronic ulcer colonitis.

Description

Technical field: [0001] The invention relates to the technical field of medicines, and relates to a new application of the water extract of Euphorbiaceae plant Amaranthus amaranth for preparing medicine for treating chronic ulcerative colitis. Background technique: [0002] Ulcerative colitis (UC), also known as chronic nonspecific colitis, is characterized by recurrent diarrhea, abdominal pain, and blood in the stool. Because the disease is protracted and difficult to heal, and it is very easy to transform into colon cancer, and there is no specific treatment method at present, it is defined by the World Health Organization as one of the "refractory diseases in the world". The incidence rate of chronic ulcerative colitis is very high in European and American countries, and the incidence rate in my country is also increasing year by year. Since the pathogenesis of the disease has not been clarified, the treatment effect is not very good. At present, the main clinical drugs...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/47A61P1/04
Inventor 胡晋红邓莉
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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