Traditional Chinese medicine combination treating hypertension and application thereof
A composition and high blood pressure technology, which is applied in the direction of drug combination, drug delivery, and medical preparations containing active ingredients, etc., can solve the problems of side effects of antihypertensive western medicines and cannot satisfy patients, and achieve non-toxic side effects, low price, The effect of wide source of raw materials
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Embodiment 1
[0015] Embodiment 1: the preparation of Chinese medicine extract
[0016] Herbal medicine prescription: tea tree root 2.8kg, plantain 2.5kg, fried tribulus terrestris 1.1kg, lotus leaf 2.1kg, cockscomb flower 1.1kg, hanging golden lamp 1.1kg, Morinda officinalis 1.1kg, cypress kernel 0.9kg, aristolochia 0.9 kg, Toosendan 0.9kg.
[0017] Preparation method: Weigh the above-mentioned Chinese medicinal materials, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, add 12 times the amount of water for the first time, decoct Boil for 2 hours, take the decoction, filter, add 10 times the amount of water of the medicinal materials for the second time, decoct for 1.5 hours, combine the two decoctions, filter, and concentrate to a concentrated solution with a relative density of 1.10 at 90°C; The concentrated solution was refrigerated at 3-5°C for 24 hours, added 0.3%...
Embodiment 2
[0018] Embodiment 2: the preparation of Chinese medicine oral liquid
[0019] Herbal medicine prescription: tea tree root 3.0kg, plantain 3.0kg, fried tribulus terrestris 1.2kg, lotus leaf 2.5kg, cockscomb 1.4kg, hanging golden lamp 1.4kg, Morinda officinalis 1.4kg, cypress kernel 1.2kg, aristolochia 1.2 kg, Toosendan 1.2kg.
[0020] Preparation method: Weigh the above-mentioned Chinese medicinal materials, wash and remove impurities, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, and add up to 12 times the medicinal materials for the first time amount of water, decoct for 2 hours, take the decoction, filter, add 10 times the amount of water of the medicinal materials for the second time, decoct for 1.5 hours, take the two decoctions and combine, filter, and when concentrated to 90 ° C, the relative density is The concentrated solution of 1.10; put the c...
Embodiment 3
[0021] The antihypertensive effect of embodiment 3 Chinese medicine extracts on spontaneously hypertensive rats
[0022] Select 40 clean grade spontaneously hypertensive rats (SHR) aged 10 weeks, male, with a body weight of 270-300g, and the SHRs are randomly divided into the following four groups: the control group and the low, medium and high dose groups of the extract. Group 10. After the test started, the control group was administered with normal saline 5ml / kgBW / d; the low, medium and high dose groups of the extract were administered with 150, 300, and 600 mg / kgBW / d of the traditional Chinese medicine extract prepared in Example 1, respectively. After the drug was dissolved in water, the drug was administered by gavage, once a day, for 8 consecutive weeks. The arterial systolic pressure of rats in awake state was measured by tail artery manometry (the tail was heated for 5 minutes). The blood pressure was measured by rat tail manometry every 2 weeks before and after the...
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