Glucose detection device and method based on optical fiber surface plasmon resonance

Abstract

The invention discloses a device and a method for detecting glucose based on optical fiber surface plasma resonance. The device comprises a light source, a polarizer, a polarization controller, a sensor probe, a filter and a photoelectric detector which are connected with each other in turn through an optical fiber, wherein the sensor probe comprises the optical fiber engraved with inclined fiber bragg gratings; a metal film in nanometer-level thickness is plated on the outer surface of the covering of the optical fiber; the light emitted from the light source passes through the polarizer and the polarization controller and then enters into the optical fiber engraved with the inclined fiber bragg gratings on the sensor probe; a covering film generated in the optical fiber is coupled with the metal film on the outer surface of the covering of the optical fiber; the surface plasma resonance is stimulated; the light containing the plasma resonance output by the optical fiber is sent into the photoelectric detector by the sensor probe through the filter. According to the invention, glucose oxidase is added into a to-be-measured serum solution, so that a hydrogen peroxide corroded metal film is formed, and the glucose concentration in the serum solution is acquired according to a response rate of the light intensity which changes along with the time and is detected and acquired by the photoelectric detector.

Description

technical field [0001] The invention belongs to the field of optical fiber biomedical sensor design, in particular to a glucose detection device and method based on optical fiber surface plasmon resonance. Background technique [0002] Diabetes is one of the most common diseases in humans. According to the World Health Organization's 2010 survey data, there are more than 285 million people with diabetes worldwide, and it is predicted that this number will double by 2030. Rapid and effective means of detecting blood sugar levels has become an important demand for modern medicine and the general public. Among the numerous blood glucose detection sensors, electrochemical sensors are the majority, but such sensors cannot realize dynamic and real-time blood glucose content detection, so they cannot grasp the current blood glucose content of the patient's blood in real time, which brings difficulties for timely drug supply. High precision and minimal invasiveness are the develop...

AI Technical Summary

Problems solved by technology

The preparation and binding of biosensitive membranes require complex processes, which affect the repeatability and stability of the sensor to a certain extent.

In addition, the traditional detection method of plasma resonance wave is based on the wavelength detection method, which requires an expensive and precise wavelength demodulator, which also limits the popularization and application of this technology

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