A micro-droplet control chip based on branch structure

Abstract

A micro-droplet control chip based on a branch structure, by adding a branch next to the main channel to achieve the purpose of separation or fusion of droplets after splitting; the branch is composed of a straight channel and a circular arc channel, using the main channel and The length of the two paths of the branch and the fluid velocity are different, and different control functions are realized by controlling the velocity of the injected liquid, specifically including the fusion of the droplets on the two paths arriving at the intersection at the same time, the uniform arrangement of the evenly spaced arrival, and the uneven spacing Arrived grouping; the discrete phase liquid flows in from the discrete phase inlet, the continuous phase liquid flows in from the continuous phase inlet, and the two meet at the junction in the main channel, the discrete phase liquid breaks to form droplets and flows downstream with the continuous phase, and finally Flow out of the chip through the outlet; due to the different lengths of the two paths and the different flow speeds of the droplets in different paths, the time intervals to reach the intersection are different, showing three different laws of fusion, uniformity, and grouping.

Description

technical field [0001] The invention relates to a microfluidic control chip that utilizes a branch structure to control the flow of microdroplets. Within a specific flow rate range, the droplet enters a certain branch at a bifurcation or splits into a certain branch, and then flows downstream The intersections meet again and present different rules such as equal spacing, grouping or fusion, realizing the flow control of micro-droplets. Background technique [0002] Microfluidic chip droplet is a kind of micro-volume liquid (10 -15 -10 - 9 L) Emerging technologies to realize various flow control or reactions. The research on micro-droplets has obtained relatively rich results, and on this basis, some generally accepted flow structures for specific applications (split, fusion, etc.) have been formed. [0003] In the biological detection or chemical reaction based on the microfluidic chip, the micro-droplet is an independent unit, which can reduce the mutual interference ca...

AI Technical Summary

Problems solved by technology

[0004] The control of micro-droplets on the chip is divided into two types: active control and passive control. The active control mainly uses pneumatic valve or electrode control, which can achieve multiple purposes and large-scale integration, and the control accuracy is high. However, the combination of these technologies To some extent, it will increase the additional components of the chip, increase the production cost, and greatly reduce the degree of portability.

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