54 results about "Droplet flow" patented technology

The utility model belongs to a spraying device, and provides a supersonic spraying device, a non-invasive spraying device and a spraying instrument.The problems that spraying is not uniform and operation is inconvenient still exist in an existing instrument, and the supersonic spraying device, the non-invasive spraying device and the spraying instrument.The supersonic spraying device comprises a liquid section, a gas inlet section, a contraction section, a throat part and an expansion section, and the gas inlet section, the contraction section, the throat part and the expansion section are coaxially and sequentially connected; liquid enters from the liquid section, gas is accelerated through the contraction section, reaches the throat part and is continuously accelerated at the expansion section, the liquid entering from the liquid section is atomized under the action of the gas at the throat part, is brought into the expansion section and is finally sprayed out from the spraying opening along with continuous acceleration, and the uniform spraying effect is achieved. According to the supersonic jet device, the ratio of the axial length L1 to the axial length L2 is designed, the structure of the supersonic jet device is further optimized, and actual verification shows that under the optimized ratio, the jet force of the supersonic jet device is obviously improved, the particle size and the jet range of jetted liquid drops are better, and the flow speed of the liquid drops is more stable.

The invention belongs to the technical field of microfluidics, and particularly relates to a microfluidic chip and a method for preparing liquid drops in a high-flux and large-scale manner. A step emulsification structure and a liquid drop splitting structure are used together, a liquid drop generation structure is arranged at the communication position of a branch splitting channel and a main channel unit correspondingly communicated with the branch splitting channel, a dispersion phase necks at the liquid drop generation structure under the action of interfacial tension to form liquid drops, and the liquid drops are generated under the leading of the interfacial tension, so that the dispersion phase is uniform in dispersion. Therefore, the size of the liquid drops is basically determined by the channel width of the liquid drop generation structure, the branch splitting channel is designed to be wide, the influence of manufacturing errors on the uniformity of the generated liquid drops can be reduced, the branch splitting channel is designed to be a plurality of serpentine channels, and the uniformity of the liquid drops is improved while high-flux liquid drop preparation is guaranteed; and then the liquid drops flow through the main channel unit and are converged into the main splitting channel, and the liquid drops are uniformly split into liquid drops with smaller sizes through the liquid drop splitting structure, so that the preparation of the liquid drops with high flux and uniform sizes is realized.

The invention discloses a method for microfluidic high-throughput screening of AKK bacteria. The method comprises the following steps: 1) preparing a microfluidic chip; 2) collecting fresh excrement of healthy volunteers, diluting, and adding a fluorescence labeled antibody to obtain a dispersion phase; and (3) preparing liquid drops by taking paraffin oil and Span-80 as a mobile phase, enabling the liquid drops to enter a liquid drop culture tank through an S-shaped liquid drop circulation channel, culturing, introducing the mobile phase, introducing the liquid drops in the liquid drop culture tank into a liquid drop collection tank, taking out, detecting a fluorescence signal, culturing the liquid drops with the fluorescence signal on the improved brain heart infusion broth solid culture medium, and obtaining the brain heart infusion broth. Obtaining a to-be-identified strain; 4, the strain to be identified serves as a template, PCR amplification is conducted, sequencing is conducted on an amplification product, BLAST sequence comparison is conducted on a sequencing result on an NCBI website, and the target strain AKK bacterium is screened out. The method has the advantages of being high in throughput, simple in experimental process and high in specificity, and the screening efficiency of the AKK bacterium can be improved.

The utility model provides non-contact biological particle treatment equipment and a biological particle treatment device. The biological particle processing device comprises a liquid droplet generating chamber, a working chamber communicated with the liquid droplet generating chamber, and a sorting chamber communicated with the working chamber. The droplet generating chamber is configured to receive a first liquid, a biological particle located within the first liquid, and a second liquid insoluble in the first liquid. The droplet generating chamber is used for enabling the flow of the second liquid to be staggered with the flow of the first liquid, so that the biological particles and the first liquid part around the biological particles jointly generate a biological particle droplet flowing to the working chamber after penetrating through the second liquid; the biological particles are cultured or tested through the first liquid. Therefore, the biological particle liquid drop can protect at least one biological particle located in the biological particle liquid drop, and culture work or detection can be completed while the biological particle liquid drop moves.

The application discloses a microfluidic droplet generation control method, device, equipment and medium, relates to the field of microfluidic droplet generation, and comprises the following steps: first, dividing nodes and judging the flow state of each node according to a limited parameter by using a flow state classifier; predicting the droplet diameter by using a stacking integrated size regression model based on an ideal droplet flow state node; screening candidate nodes based on an accuracy tolerance constraint; determining local sensitivity based on a virtual flow rate micro-perturbation and a flow state boundary risk penalty; determining a robust candidate solution set based on a comprehensive risk score according to the local sensitivity and a confidence interval width; extracting a cluster and a representative solution for each candidate node in the robust candidate solution set; and calculating the two-phase flow control parameters for the representative solution of each cluster in the dimension of the continuous phase flow rate and the dispersed phase flow rate by using a univariate step-by-step double-criterion termination algorithm based on a cascade model, so that the time cost and the material cost are reduced.

This invention discloses a piezoelectric valve nozzle cleaning management method and system based on identifier traceability, specifically relating to the field of piezoelectric jet equipment operation and maintenance technology. The method involves reading the unique identifier of the piezoelectric valve nozzle to trace individualized cleaning records; dynamically generating customized cleaning strategies based on the records, determining the solvent type and piezoelectric excitation waveform parameters; first, driving a small atomizing valve to generate an atomized cloud for non-destructive pre-wetting of the nozzle surface, then driving the piezoelectric valve for active excitation cleaning; driving the small atomizing valve to generate standardized droplet flow as a probe, capturing the characteristic spectrum after passing through the nozzle area through a detection unit and comparing it with a standard spectrum to quantitatively evaluate the cleaning effect and accurately locate the blocked nozzle; updating the records based on the detection results, and if the cleaning is unqualified, optimizing the strategy based on the blockage location information and iteratively executing it until qualified.

The application discloses a non-contact flow field measuring device and method with nitrogen droplets as tracer particles, and belongs to the technical field of flow field visualization. A Laval nozzle is used as a nitrogen droplet generating device, and the Laval nozzle is arranged in a high-speed flow section. After the nitrogen droplets flowing out of the Laval nozzle are mixed with the main flow in the high-speed flow section, the nitrogen droplets pass through an expansion section and a flow regulation section and then enter a speed measuring section. A high-speed camera is used in the speed measuring section to capture the nitrogen droplets and obtain the air flow speed. By actively regulating and controlling the operating parameters of the wind tunnel, the total temperature, the Ma number and the expansion ratio of the Laval nozzle in the wind tunnel are reasonably controlled, so that the condensation nitrogen droplets are spontaneously generated at a proper position, the condensation degree is controlled, and the disturbance of the flow field near the test model is reduced as much as possible. The application aims to solve the key problem that suitable and available tracer particles are lacked in the application of the non-contact measurement technology in a low-temperature wind tunnel, and provides a new feasible way for the application of the non-contact flow field measurement technology in a transonic low-temperature wind tunnel.

The application relates to a device and a method for realizing particle aggregation in a droplet, which comprises: a microfluid channel for providing a channel for droplet flow; a first bulk acoustic resonator close to the microfluid channel, the working range of the first bulk acoustic resonator including the space in the microfluid channel; the overall shape of the first bulk acoustic resonator is arranged to be narrowed from the front end to the tail end, and the tail end is an outwardly convex arc-shaped end portion, the arc-shaped end portion being used for making particles in the droplet be aggregated at a first position in the droplet during the process that the droplet flows through the first bulk acoustic resonator; and the tail end is located on the downstream side in the microfluid channel relative to the front end. The scheme of the application can realize that particles in the droplet are aggregated at a first position in the droplet, so as to facilitate observation or the interaction of different particles in the droplet after aggregation.

To accurately detect fine particles without complicating a device configuration.SOLUTION: The condensation particle counter includes a supply unit configured to supply a working fluid to a periphery of an inlet of a condensation tube through which an aerosol containing sample particles flows, a saturation unit configured to saturate the aerosol with vapor of the working fluid, and a control unit configured to condense and grow the aerosol into droplets using the sample particles as nuclei and extract the aerosol containing the droplets from a center axis of a condensation-growth tube connected to the condensation tube. A condensation and growth section that and exhausts excess working fluid that has flowed down an inner wall of a condensation and growth tube, vapor of the working fluid that has condensed on the inner wall, and water vapor together with excess aerosol, a flow rate control section that controls a flow rate of the aerosol flowing through a capillary tube that the aerosol containing droplets after condensation and growth at a minute flow rate, a double cylindrical sheath flow that positions the aerosol that has passed through the capillary tube on an extension line of a central axis of the capillary tube, and a droplet counting section that counts the droplets contained in the aerosol based on the droplets flowing through the capillary tube, wherein the working fluid contains an alkane having a carbon number of 14 or less.SELECTED DRAWING: Figure 1

A miniaturized, automated method for controlled printing of large arrays of nano- to femtoliter droplets by actively transporting mother droplets over hydrophilic-in-hydrophobic (“HIH”) micropatches. The technology uses single or double-plate devices where mother droplets can be actuated and HIH micropatches on one or both plates of the device where the droplets are printed. Due to the selective wettability of the hydrophilic micropatches in a hydrophobic matrix, large nano- to femtoliter droplet arrays are created when mother droplets are transported over the arrays. The parent droplets are moved by various droplet actuation principles. Also, a method using two plates placed one top another while being separated by a spacer. One plate is dedicated to confirming and guiding parent droplets by using hydrophilic patches in a hydrophobic matrix, while the other plate contains HIH arrays for printing of the droplets. When the parent droplet guidance plate is rotated over the plate dedicated to printing of nano- to femtoliter droplets, the droplets are dispensed inside the HIH array utilizing their selective wettability. The methods allow the parent droplets to move over the HIH arrays many times, providing advantages for performing bio-assays or miniaturized materials synthesis in nano- to femtoliter sized droplets. With controlled evaporation of the dispensed droplets of solution, large arrays of printed material can be generated in seconds. The methods provide a nano- to femtoliter droplet printing technique for a wide variety of applications, e.g., protein- or cell-based bio-assays or printing of crystalline structures, suspensions of nanoparticles or microelectronic components.

Copper-boron-ferrite (Cu—B—Fe) composites may be prepared and immobilized on graphite electrodes in a silica-based sol-gel, e.g., from rice husks. Different bimetallic loading ratios can produce fast in-situ electrogeneration of reactive oxygen species, H2O2 and ·OH, e.g., via droplet flow-assisted heterogeneous electro-Fenton reactor system. Loading ratios of, e.g., 10 to 30 wt. % Fe3+ and 5 to 15% wt. Cu2+, can improve the catalytic activities towards pharmaceutical beta blockers (atenolol and propranolol) degradation in water. Degradation efficiencies of at least 99.9% for both propranolol and atenolol in hospital wastewater were demonstrated. Radicals of ·OH in degradation indicate a surface mechanism at inventive cathodes with correlated contributions of iron and copper. Copper and iron can be embedded in porous graphite electrode surface and catalyze the conversion of H2O2 to ·OH to enhance the degradation. Inventive cathodes can be stable catalytically after 20 or more cycles under neutral and acidic conditions.

Systems and methods for initializing an extreme ultraviolet (EUV) source are discussed. The EUV radiation source may include a droplet generator configured to generate a stream of droplets of a target material, a laser source communicatively coupled to a controller. The laser source is configured to generate a first pulsed beam of light, which upon interaction with a droplet, initiates a modification of a shape of the droplet, forming a modified droplet, and generate a second pulsed beam of light configured to substantially evaporate the modified droplet, thereby generating pulses of EUV light. The EUV radiation source comprises a first actuator communicatively coupled to the controller and configured to adjust a width of the second pulsed beam to minimize a variation of energy of the pulses of EUV light.

The application discloses a kind of multi-component monodisperse microdroplet digital electric control system and method, comprising: multi-component droplet generation module, for obtaining microdroplet by controlling the flow ratio between dispersed phase and continuous phase;Multi-component droplet digital electric control module is used to control the deformation, movement and fusion of the microdroplet by the combination electrode of several sharp electrodes and flat angle electrodes;The multi-component droplet generation module and multi-component droplet digital electric control module are connected by the flow channel of PVA solution injection, and are located on microdroplet chip.This application realizes the control of microdroplet component structure and the control of microdroplet size flow rate by adjusting flow ratio and adjusting overall flow rate through discrete droplet generation unit and multi-component droplet flow focusing structure, and finally forms a complex multi-component droplet independent generation system.

In one embodiment, a system includes a flow cell with a conductive electrode and a base having an opening allowing variable charged sheathed sample fluid to flow out along a fluid axis, a droplet deflection unit with a pair of charge plates and a deflection chamber with a pivot door closing over the chamber a hardware triggered camera mounted to the back of the deflection chamber, and an LED array strobe light mounted to the pivotal door opposite the camera. The LED array strobe light generates a backlighting for various droplet streams. Triggering of the camera is synchronized with the generation of the backlighting to periodically capture a brightfield still image of deflected droplets and center droplets in the deflection chamber. The captured images can be analyzed for droplet deflection angles and center line for visual feedback control of the deflected droplets and the center droplets in respective droplet streams.

To provide a droplet deflector having an optimized deflection plate.SOLUTION: Droplet deflectors of interest include droplet deflectors comprising deflection plates configured for high angle deflection of a droplet flow stream. Droplet deflectors of interest further include those comprising deflection plates having a shape corresponding to the path of the deflected droplet flow stream, or deflection plates configured to apply a deflection force to the flow stream at a plurality of different angles. Droplet deflectors of interest further include droplet deflectors that are configured to apply a constant deflection force to the deflected droplet flow stream from a plurality of different lateral positions, e.g., wherein the deflector plate is a segmented deflector plate. Further provided are flow cytometers comprising the subject droplet deflectors, as well as methods of using and assembling or configuring the same.SELECTED DRAWING: None

An illumination source includes a droplet generator, a laser, a detector, and a controller. The droplet generator produces a stream of droplets of target material directed to an interaction region. The laser irradiates the droplets at the interaction region using a beam of pulses. The irradiated droplets generate output illumination of the illumination source. The detector measures an aspect of an interaction between a pulse from the beam and a droplet from the stream. Controller includes circuitry and determines a pulse timing adjustment that is nonlinearly dependent on the measured aspect. The controller also controls a subsequent laser pulse of the beam based on the pulse timing adjustment.

Aspects of the present disclosure include a particle sorter with a droplet deflector configured to apply a known offset deflection force to a droplet stream. Particle sorters according to certain embodiments include a flow cell, a light source, e.g., laser, for irradiating an interrogation point of the flow cell, a detector for detecting light from the interrogation point, a droplet generator for producing a droplet stream from fluid exiting the flow cell and a droplet deflector configured to apply a known offset deflection force to the droplet stream. In some cases, the droplet deflector comprises first and second plates configured to be offset from one another. Methods and particle sorting modules for applying a known offset deflection force are also provided.

In one embodiment, a system includes a flow cell with a conductive electrode and a base having an opening allowing variable charged sheathed sample fluid to flow out along a fluid axis, a droplet deflection unit with a pair of charge plates and a deflection chamber with a pivot door closing over the chamber a hardware triggered camera mounted to the back of the deflection chamber, and an LED array strobe light mounted to the pivotal door opposite the camera. The LED array strobe light generates a backlighting for various droplet streams. Triggering of the camera is synchronized with the generation of the backlighting to periodically capture a brightfield still image of deflected droplets and center droplets in the deflection chamber. The captured images can be analyzed for droplet deflection angles and center line for visual feedback control of the deflected droplets and the center droplets in respective droplet streams.

The embodiment of the present application discloses a kind of microfluidic chip.The microfluidic chip includes oppositely arranged first substrate and second substrate, microfluidic channel is formed between first substrate and second substrate, microfluidic channel is used to accommodate at least one droplet;Multiple drive electrodes, multiple first sensing electrodes and multiple second sensing electrodes are located on the side of first substrate, adjacent drive electrodes are loaded with different drive voltage signals to drive droplet to move;First sensing electrode and second sensing electrode are loaded with detection signal, and the position of droplet is determined according to the change of the capacitance formed by first sensing electrode and a certain electrode and the change of the capacitance formed by second sensing electrode and a certain electrode when droplet flows.The microfluidic chip provided by the present application can obtain the position of droplet while driving the movement of droplet, and solve the problem of low reliability of equipment caused by the inability to detect the position of droplet in the prior art.

This invention relates to the field of droplet hydrodynamics, specifically to a visualization experimental system and method for studying droplet thermocapillary phenomena. The visualization experimental system for studying droplet thermocapillary phenomena includes: a droplet control device, a heating device, and a data acquisition device. The droplet control device generates two suspended droplets and controls at least one of the suspended droplets to approach and collide with the other droplet in a horizontal direction. The two suspended droplets contain fluorescein and tracer particles. The heating device radiates ultraviolet light onto the two suspended droplets and controls their temperature. The data acquisition device acquires video and real-time images of at least one of the suspended droplets approaching and colliding with the other droplet in a horizontal direction.

A system is provided that can reduce EUV generation instability to improve the accuracy of EUV lithography tools. The system (600) includes a first portion (604) and a second portion (606) of an alignment mechanism. The first portion is coupled to a nozzle (602) in a droplet generating device. The second portion is coupled to an exterior surface (608) of the droplet generating device. The second portion includes a second adjustment mechanism (612) for adjusting a first adjustment mechanism (610) of the first portion to align the nozzle so that droplets travel from the nozzle substantially along a droplet path (614).

The invention discloses a method and a system for testing fluctuation characteristics of a liquid film outside a drip flow horizontal tube, and belongs to the technical field of drip flow fluctuation characteristic testing. The system comprises a horizontal heat transfer tube, a drop-shaped flow liquid film, an adjustable LED mounting plate, an LED light source, a CCD high-speed camera and a computer, the adjustable LED mounting plates are mounted at two ends of the outer edge of the drop-shaped flow liquid film outside the horizontal heat transfer tube, the two LED light sources are fixed on the adjustable LED mounting plates, and the CCD high-speed camera directly faces the two LED light sources and is connected with the computer. A non-contact visual optical test technology and a scientific data processing method are adopted, interference of a direct contact measurement technology on a thin fluctuating liquid film is avoided, accurate measurement of the fluctuation characteristics of the liquid film outside the pipe in the circumference and the three-dimensional direction of the pipe length is achieved, the problem that complex and random experimental data of the fluctuation characteristics of the liquid film are difficult to process in the prior art is solved, and the experimental accuracy is improved. And meanwhile, the real mechanism and reason of enhanced heat transfer of the drop-shaped flow liquid film under the actual fluctuation condition can be analyzed.

Droplet deflectors having optimized deflection plates are provided. Droplet deflectors of interest include droplet deflectors with deflection plates configured for high-angular deflection of a droplet flow stream. Droplet deflectors of interest further include droplet deflectors with deflection plates that comprise a shape that corresponds to a path of the deflected droplet flow stream or deflection plates configured to apply a deflection force to a flow stream at a plurality of different angles. Droplet deflectors of interest still further include droplet deflectors configured to apply a constant deflection force to the deflected droplet flow stream from a plurality of different lateral positions, including, for example, where the deflector plates are segmented deflector plates. Flow cytometers having the subject droplet deflectors and methods of use and configuration or design thereof are also provided.

The utility model provides a kind of atomizing head of increasing fog output, including atomizing head main casing, upper cover, baffle, atomizing core seat and atomizing core, atomizing cavity and fog outlet nozzle are provided on atomizing head main casing, atomizing core seat is inserted into atomizing head main casing, atomizing core is connected on atomizing core seat and located in atomizing cavity, atomizing core seat provides airflow and liquid to atomizing core, the upper portion of atomizing head main casing is provided with the opening being communicated with atomizing cavity, upper cover is installed at opening, nozzle is equipped at the output end of fog outlet nozzle, the output end of the fog outlet nozzle is blocked by the nozzle, the nozzle is formed with spout, the output end of fog outlet nozzle is blocked by nozzle, atomized droplet is sprayed from spout;Like this, the speed of droplet flow through spout is accelerated, avoid backflow phenomenon in fog outlet nozzle, increase the fog output of atomizing head.

A method for accurately capturing droplet topological structure evolution in a drop flow falling film process belongs to the technical field of falling film evaporation research, combines computational fluid dynamics (CFD) software Fluent, and utilizes a user-defined equation to introduce a dynamic contact angle model into a mathematical model, so as to accurately capture the droplet topological structure evolution in the drop flow falling film process. The invention provides a method for accurately capturing the evolution of a liquid drop topological structure in a drop flow falling film process. According to the method, two-dimensional and three-dimensional falling film evaporation physical models are constructed, liquid drop topological structure evolution, film thickness distribution and speed and pressure distribution of liquid drops in the axial and circumferential spreading process of a horizontal pipe are analyzed, and causes of phenomena of circumferential spreading of liquid rings, liquid drop pulsation, axial shrinkage and the like of the liquid drops are clarified; according to the method, the flow mechanism of the drop flow falling film can be deeply understood, and an important theoretical basis and a numerical simulation means are provided for design and optimization of an efficient falling film evaporator.

The invention provides a bionic stomach micro-fluidic chip based on liquid drop micro-fluidic control and mechanical force stimulation and application of the bionic stomach micro-fluidic chip. The bionic stomach micro-fluidic chip comprises a liquid drop generation module and a mechanical force stimulation module. The liquid drop generation module is used for dispersing artificial stomach digestive juice and a to-be-digested Newtonian fluid sample in an oil phase by utilizing a micro-fluidic chip structure to form monodispersed water-in-oil liquid drops to simulate a discrete chyme group; and the mechanical force stimulation module is provided with a micro-channel with a periodically variable cross section. When liquid drops flow through the flow channel, the liquid drops are extruded and deformed periodically, a complex flow field is generated in the liquid drops, and the mechanical kneading effect of stomach wall wriggling on chyme balls is simulated. By limiting biochemical reaction in micro-droplets and applying controllable physical shear force, collaborative high-fidelity simulation of chemical and mechanical effects in the gastric digestion process is realized, and the problems that a traditional static model is low in simulation degree and large dynamic equipment is low in flux and high in cost are solved. And a brand new high-throughput research platform is provided for the fields of food and medicine.

The utility model relates to air sampling technical field, concretely relates to a kind of air sampling multistage dehumidification device for rail transit, including sampling collection pipe, filter module, U-shaped tube, gas analysis module in turn along gas flow direction;It further includes primary water droplet flow guide structure, secondary extrusion structure, tertiary discharge structure, respectively for promoting the condensation of water vapor in sampling collection pipe into water droplet and flow guide discharge, for extruding the adsorbed water of filter sponge adsorption in filter module, for collecting the water drop of filter sponge seepage or extrusion.The utility model adds primary water droplet flow guide structure, secondary extrusion structure, tertiary discharge structure in correspondence in sampling collection pipe, filter module, U-shaped tube, carries out flow guide collection to water vapor water droplet etc., multiple protection is realized, prevent water droplet flow into gas analysis module, thus can avoid affecting gas monitoring work and avoid causing economic loss.

In one embodiment, a system includes a flow cell assembly having a flow cell body with a base having an opening allowing sheathed sample fluid to flow out, a bracket coupled to the flow cell body, a flat mirror mounted to the bracket, a hardware triggered camera coupled to the bracket on one side, and a diffused light emitting diode strobe light coupled to the bracket on an opposite side. The camera and strobe light are pointed at the mirror on opposite sides. Activation of the diffused LED strobe light generates a diffused strobe light into the mirror backlighting a droplet stream. Triggering of the camera is synchronized with the generation of the strobe light to periodically capture a brightfield still image of the droplet stream. The image can be analyzed for measured jet breakoff point and measured droplet interval point for visual feedback control of the droplet stream.

This invention discloses a method for preparing diether fluorene using microchannel reaction, comprising the following steps: (1) mixing 9-fluorenone, phenoxyethanol, and a co-catalyst at a certain temperature to form a uniform mobile phase 1, and using a strong acid catalyst as a mobile phase 2; (2) injecting mobile phase 1 and mobile phase 2 into a microchannel at a certain flow rate ratio and total volumetric flow rate to form a droplet flow for reaction, and diffusing the obtained product to a liquid-liquid separator, where the liquid and liquid phases are separated to obtain an ethyl acetate phase and an aqueous phase. The aqueous phase is used to recover the strong acid, and the ethyl acetate phase is concentrated and crystallized to obtain high-purity diether fluorene. This invention is the first to utilize microfluidic technology to prepare diether fluorene using 9-fluorenone and phenoxyethanol as the main reactants. The process is simple, energy-efficient, has a short reaction time, is green and safe, and is economical, making it suitable for large-scale production.