Device and method for producing and measuring droplet on micro-fluidic chip

Abstract

The invention discloses a device for producing and measuring droplets on a micro-fluidic chip. The device comprises a rotating platform with adjustable rotation speed, a micro-fluidic chip and micro-flow pipes disposed on the micro-fluidic chip. The device also comprises auxiliary rotating shafts and two locking valves. The two locking valves are arranged at two sides of the micro-fluidic chip respectively. The micro-fluidic chip can rotate around the auxiliary rotating shafts. Included angles between micro-flow pipe directions and radial directions of the rotating platform are adjusted through rotation acceleration of the rotating platform. The micro-fluidic chip is locked on two states by the locking valves, so as to change droplet flow directions in the micro-flow pipes. Each micro-flow pipe comprises a first horizontal reversible pipe, a radial normal-open pipe, a second horizontal reversible pipe and a main pipe. The invention also discloses a method based on the device. By periodically switching rotation directions of the rotating platform, production and measurement of the droplets on the micro-fluidic chip are realized; a structure is simple; cost is low and operations are convenient.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a device and method for generating and measuring droplets in a microfluidic chip. Background technique [0002] Microfluidic chip is an emerging technology platform. Microfluidic chip technology is also known as "Lab on a Chip" or Lab On A Chip, which integrates the entire reaction and analysis process of biology, chemistry, and medicine into one chip, and automatically completes the entire complex process previously completed in the laboratory. the whole process of the experiment. This includes basic operating procedures such as sample preparation, reaction, separation, and detection. Due to its great potential in the fields of biology, chemistry, and medicine, it has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. [0003] Centrifugal force drive uses the centrifugal force generated wh...

AI Technical Summary

Problems solved by technology

Since the traditional centrifugal force platform does not have a power supply system, the operations on the chip are mainly passive operations, and it is impossible to perform high-precision temperature detection and heating operations on parts of the chip.

The existing technology cannot achieve the periodic generation of equivalent droplets by periodically switching the state of the multi-state chip platform, the structure is not simple, and the operation is inconvenient and other defects

Images