Liquid chromatography mass spectrometer device

A liquid chromatography mass spectrometry and analysis device technology, which is applied in the fields of analyzing materials, measuring devices, and material analysis by electromagnetic means, can solve problems such as the reduction of ionic strength, and achieve the effect of promoting ionization

Inactive Publication Date: 2014-03-12
HITACHI HIGH-TECH CORP
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0011] However, although the analysis accuracy can be improved by excluding large droplets, the ionic strength itself is reduced. In order to ensure the ionic strength with better sensitivity, large droplets also need to efficiently vaporize the solvent in the droplets.

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Embodiment Construction

[0037] Hereinafter, embodiments of the present invention will be described with reference to the drawings.

[0038] first of all, yes figure 1 The shown liquid chromatography-mass spectrometry device includes figure 2 , Figure 4 to explain.

[0039] The liquid chromatograph 1 includes, for example, a pump, an autosampler, a hollow column (karam oopn), and a UV detector. The sample solution eluted in the liquid chromatograph 1 is supplied to a mass spectrometer and subjected to mass spectrometry. The mass spectrometer includes an ionization unit 6 (ion generation unit), an ion guide (ion guide) 9 , and a mass spectrometry unit 10 .

[0040] In addition, the mass spectrometer includes a sample spraying part 2 for spraying the ion source sample, a heating gas supply part 3, a first fine hole member 7 provided with a first fine hole, and a desolvation channel chamber 4 provided with an inverted conical shape. The desolvation part 14, the needle electrode 5 as an ion generat...

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Abstract

The purpose of the present invention is to provide a mass spectrometer device with a high detection sensitivity, achieved by efficiently vaporizing a sprayed sample solution in order to generate charged microdroplets and thereby improve the efficiency of sample ionization, and to reduce large droplets with high ionic strength. The present invention is a liquid chromatography mass spectrometer device having: a liquid chromatographic separation means which separates a sample solution into the respective components thereof, a sample spraying unit which sprays, as droplets, the sample solution separated and eluted by the liquid chromatographic separation means, an ion generation means which generates ions by charging the droplets (droplet charging), a mass spectrometer unit which receives and separates the ions, and a desolvation unit which removes the solvent contained in the charged droplets. The present invention is characterized by the desolvation unit having a desolvation flow chamber through which the charged droplets flow, a heating means which heats the desolvation flow chamber, and a helical droplet conduit provided in the desolvation flow chamber.

Description

technical field [0001] The present invention relates to a liquid chromatography-mass spectrometry device that ionizes droplets of a liquid sample supplied from a liquid chromatography unit (LC) and introduces them into mass spectrometry (MS). Background technique [0002] In recent years, in the fields of environment, food, medicine, forensic science, etc., mass spectrometers have been widely used as a method for obtaining qualitative / quantitative information with high sensitivity for trace amounts (ppm to ppb order) of multiple components. However, in many ionization methods used in mass spectrometers, it is difficult to accurately characterize the ionization of the target component due to the interference caused by the influence of the inclusion component (multiple component) in the multi-component system. / quantitative analysis of the situation. [0003] Therefore, prior to detection with a mass spectrometer, a chromatographic separation device such as a liquid chromatog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62G01N30/72
CPCH01J49/10H01J49/044G01N30/7266H01J49/049
Inventor 吉冈信二安田博幸
Owner HITACHI HIGH-TECH CORP
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