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Application of Ginkgo biloba in the preparation of drugs for the treatment of Streptococcus suis infection

The technology of streptococcus suis and ginkgo can be applied in the field of medicine and can solve the problem of streptococcus suis infection which is not seen in ginkgo.

Active Publication Date: 2019-04-09
JILIN UNIV FIRST HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But up to now, there are no reports of Ginkgo biloba treating Streptococcus suis infection at home and abroad

Method used

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  • Application of Ginkgo biloba in the preparation of drugs for the treatment of Streptococcus suis infection
  • Application of Ginkgo biloba in the preparation of drugs for the treatment of Streptococcus suis infection

Examples

Experimental program
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Embodiment Construction

[0008] 1. Hemolysis test

[0009] The purified streptolysin was serially diluted twice in a 96-well plate, and 10 7 Rabbit erythrocytes were incubated at 37°C for 30 minutes and then centrifuged. Among them, the highest dilution factor that lyses red blood cells is regarded as the hemolysis titre (Hemolysis titre).

[0010] The hemolytic titers of suis streptolysin treated with different concentrations of ginkgo are shown in Table 1:

[0011] Table 1. Inhibitory effect of ginkgo on hemolytic activity of streptolysin

[0012] Ginkgo biloba (μg / ml)

Hemolysis titre

0

4096

2

512

4

128

8

16

16

2

[0013] 2. Protective test of Ginkgo biloba on J774 cell injury mediated by Streptococcus suis

[0014] Streptococcus suis was cultured in THB medium to OD600nm=0.8, 5ml of bacterial culture was taken, centrifuged and resuspended in 10ml of DMEM medium. J774 cells were cultured in DMEM medium (adding 10% fetal bovine serum...

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Abstract

The invention discloses application of ginkgetin in preparation of drugs for treating streptococcus suis infection. A rabbit red blood cell hemolytic test, a macrophage (J774) damage protection test and a therapeutical effect test on mouse streptococcus suis infection prove that ginkgetin has a better curative effect on streptococcus suis infection. According to the application of ginkgetin in preparation of drugs for treating streptococcus suis infection, provided by the invention, compared with treatment with antibiotics, treating streptococcus suis infection with ginkgetin has the advantages of no drug resistance and high cure rate, therefore, ginkgetin can be used for development of new drugs for resisting streptococcus suis infection, and is of great significance in determination of drug target.

Description

technical field [0001] The invention relates to the application of ginkgo in the preparation of medicine for treating Streptococcus suis infection, which belongs to the field of medicine. Background technique [0002] Ginkgo biloba exists in the leaves and outer testa of Ginkgo biloba. Ginkgo biloba has a variety of biological activities, and also has the effects of dilating blood vessels and treating angina pectoris. As a new type of natural efficacy factor, ginkgo plays an important role in the food industry and pharmaceutical industry. But up to now, there are no reports of Ginkgo biloba treating Streptococcus suis infection at home and abroad. [0003] Streptococcus suis is a serious worldwide zoonotic infectious pathogen that can cause meningitis, sepsis and endocarditis in humans and animals; in addition, it can also cause many diseases such as kidney, liver, lung and heart. Organ failure and death and permanent loss of hearing. OIE classifies Streptococcus suis in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P31/04
Inventor 邓旭明王建锋李根马赫然卢葛锦张冰
Owner JILIN UNIV FIRST HOSPITAL
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