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mir-204 and mir-211 and their uses

A technology of uses and reagents, applied in the field of miR-204 and miR-211 and their uses, can solve problems such as increased angiogenesis

Active Publication Date: 2018-10-12
フォンダツィオーネテレトン
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Use of miR-211 purportedly leads to increased angiogenesis

Method used

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  • mir-204 and mir-211 and their uses
  • mir-204 and mir-211 and their uses
  • mir-204 and mir-211 and their uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0117] Materials and Methods

[0118] sequence

[0119] >hsa-mir-204SEQ ID NO:6

[0120]

[0121] - Mature sequence (bold) from base 33 to base 54

[0122] - Seed sequence (underlined) from base 33 to base 39

[0123] >mmu-mir-204SEQ ID NO:7

[0124]

[0125] - Mature sequence (bold) from base 6 to base 27

[0126] -Seed sequence (underlined) from base 6 to base 12

[0127] >hsa-mir-211SEQ ID NO:8

[0128]

[0129] - Mature sequence (bold) from base 26 to base 47

[0130] - Seed sequence (underlined) from base 26 to base 32

[0131] >mmu-mir-211 SEQ ID NO:9

[0132]

[0133] - Mature sequence (bold) from base 26 to base 47

[0134] - Seed sequence (underlined) from base 26 to base 32

[0135] >pAAV.CMV.precursor miR204SEQ ID NO:10

[0136] The underlined sequence is the sequence of pre-miR204

[0137] AGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTGAGCGCAACGCAATTAATGTGAGTTAGCTCACTCATTAGGCACCCCAGGCTTTACACTTTAT...

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Abstract

The present invention relates to at least one agent capable of increasing the level of one or more miRNAs comprising the sequence UUCCCUU in cells of a subject, related pharmaceutical compositions, nucleic acids, vectors and host cells, said agents being useful in therapy and / or Prevention of retinal dystrophies, especially those characterized by degeneration of photoreceptor cells.

Description

technical field [0001] The present invention relates to at least one agent capable of increasing the level of one or more miRNAs comprising the sequence UUCCCUU in cells of a subject, related pharmaceutical compositions, nucleic acids, vectors and host cells, said agents being used for treatment and / or Prevention of retinal dystrophies, especially those characterized by degeneration of photoreceptor cells. Background technique [0002] MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play key roles in the control of fundamental biological processes in physiological and pathological states. Accumulating evidence indicates that miRNAs can control specific functional pathways by targeting gene networks of functionally related genes. In humans, dysregulation of miRNA expression by mutations in miRNAs themselves or in their target genes has been associated with various pathological conditions such as diabetes, neurodegenerative diseases, heart failu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/113A61K31/713A61P27/02
CPCC12N15/113C12N2310/141A61K31/7105A61P27/02C12N2710/10043A61K48/005C12N15/86C12N2710/10032
Inventor E·M·瑟瑞斯S·班菲I·孔特M·卡拉里E·马鲁可
Owner フォンダツィオーネテレトン
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