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Injection solvent and preparation method and application thereof

A technology for injections and water for injections, applied in the direction of anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve the problems that the therapeutic effect of pharmaceutical ingredients cannot be substantially coordinated, and the ingredients are complex, so as to enrich varieties, reduce toxic and side effects, Improve the efficacy of treatment

Inactive Publication Date: 2016-01-27
SHANGHAI JINWEIZI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] To sum up some of the solvents in the prior art, it is found that the solvents and additives in the prior art are complex in composition, and can only play auxiliary functions such as balancing osmotic pressure, replenishing energy and anti-oxidation, and cannot substantially synergize the ingredients of the drug In order to achieve a more efficient therapeutic effect and reduce the side effects of drugs
At present, there is no injection solvent in the field of injection industry that can not only play an auxiliary role but also substantially cooperate with drugs to achieve high-efficiency therapeutic effects and reduce drug side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: A kind of injection solvent disclosed by the present invention, its composition includes hydrogen gas, water for injection, osmotic pressure regulator, the three can be mixed in any proportion, the obtained injection solvent is mixed with the medicament components, and the injection is obtained, which can be given to patients intravenously injection.

[0027] The injection that the present invention obtains is checked according to two appendix IB of Chinese Pharmacopoeia 2000 edition, and the result meets the various regulations under the injection item; Checked according to Chinese Pharmacopoeia 2000 edition two appendix H, pH value is 5.5-7.0, meets injection regulation ; According to the Chinese Pharmacopoeia 2000 edition two Appendix C inspection, insoluble particles and abnormal toxicity in line with the provisions of intravenous administration. Carry out the pyrogen inspection according to the two appendix XIDJI of Chinese Pharmacopoeia edition in 20...

Embodiment 2

[0031] Embodiment two: a kind of injection solvent disclosed by the present invention, its composition comprises hydrogen, water for injection, osmotic pressure regulator, wherein, the mass concentration of hydrogen is 0.8ppm, and osmotic pressure regulator selects sodium chloride, and sodium chloride is in the injection The mass percentage in the solvent is 0.6%, and the balance is water for injection.

[0032] The method for preparing the above-mentioned injection solvent comprises the following steps, (1) after adding activated carbon to the mixed solution of water for injection and osmotic pressure regulator, the amount of activated carbon added is 0.1g / ml, and the above-mentioned mixed solution is boiled, filtered and cooled, After the mixture is boiled, make up with water for injection, and after filtering, cool the filtrate to 4°C-25°C;

[0033] (2) Adopt gas / liquid mixing method to feed hydrogen into the mixed solution after the above-mentioned treatment, then filter w...

Embodiment 3

[0036] Embodiment three: a kind of injection solvent disclosed by the present invention, its composition comprises hydrogen, water for injection, osmotic pressure adjusting agent, wherein, the mass concentration of hydrogen is 1.0ppm, and osmotic pressure adjusting agent selects sodium chloride, and sodium chloride is in the injection The mass percentage in the solvent is 0.9%, and the balance is water for injection.

[0037] The method for preparing the above-mentioned injection solvent comprises the following steps, (1) after adding activated carbon to the mixed solution of water for injection and osmotic pressure regulator, the amount of activated carbon added is 1g / ml, the above-mentioned mixed solution is boiled, filtered, cooled, mixed After the solution is boiled, make up with water for injection, and after filtering, cool the filtrate to 4°C-25°C;

[0038] (2) Adopt hollow fiber membrane separation method to feed hydrogen into the mixed solution after the above-mention...

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Abstract

The invention discloses an injection solvent and a preparation method of the injection solvent. The injection solvent comprises hydrogen, injection water and an osmotic pressure regulator. The preparation method includes the steps of firstly, adding activated carbon into the mixed liquid of the injection water and the osmotic pressure regulator, then boiling the mixed liquid, filtering and cooling; secondly, feeding the hydrogen into the processed mixed liquid, filtering with a micro-pore filtering membrane to obtain the injection solvent, filling the injection solvent in a glass bottle and sealing, sterilizing, and packaging the injection solvent which is qualified after light inspection. The invention further discloses application of the injection solvent serving as medicine. The injection solvent has the advantages that injection solvent varieties are enriched, the problem that the injection solvent is single in effect is solved, osmotic pressure can be balanced while instability caused by the oxidation of the main medicine in injection can be prevented, the injection solvent can cooperate with the medicine to increase curative effect, medicine toxic and side effects can be reduced, and a direction for future injection solvent development is developed.

Description

technical field [0001] The invention belongs to the technical field of injection medicines, in particular to an injection solvent, its preparation method and application. Background technique [0002] Injections generally include the main drug, solvent and additives. The solvent can dissolve the ingredients well. The osmotic pressure regulator can not only maintain the osmotic pressure of human cells, but also provide energy for the human body. In the prior art, physiological saline, glucose, etc. are mostly used as osmotic pressure regulators. Physiological saline refers to a sodium chloride solution commonly used in physiology or clinical practice with an osmotic pressure equal to that of animal or human plasma. When used as an injection, it generally needs to be sterilized to obtain sterile saline. Its function is to maintain a balanced penetration of human cells. Glucose, in addition to adjusting the osmotic pressure, directly enters the blood circulation through intrav...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/04A61K33/00A61P9/10A61P3/10A61P1/16A61P25/28A61P35/00A61P29/00
Inventor 丛峰松戚冰雪陈迪
Owner SHANGHAI JINWEIZI BIOTECH CO LTD
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