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Valsartan/felodipine compound preparation and preparation method thereof

A technology of dipine compound and felodipine applied in the field of medicine

Inactive Publication Date: 2016-02-03
HARBIN SHENGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical studies have shown that the antihypertensive effect of the dual drug regimen is reliable and stable, but it cannot meet the market demand

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of valsartan / felodipine compound preparation, it is characterized in that: comprise principal agent and auxiliary material, wherein principal agent composition comprises valsartan, felodipine is formed; Wherein auxiliary material comprises filler, disintegrant, binding agent, Composed of lubricant and glidant; the percentages of various materials are: main drug 35-65%, filler 15-55%, disintegrant 3-18%, binder 0.1-25%, lubricant And glidant 0.01 ~ 5%.

Embodiment 2

[0031] The weight ratio of valsartan and felodipine in the main drug is 32:1, 16:1 or 8:1.

Embodiment 3

[0033] The filler is one or more of microcrystalline cellulose, starch, dextrin, pregelatinized starch and lactose.

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Abstract

The invention discloses a valsartan / felodipine compound preparation and a preparation method thereof. The valsartan / felodipine compound preparation comprises a main drug and an auxiliary material, the main drug comprises valsartan and felodipine; and the auxiliary material comprises a filler, a disintegrating agent, an adhesive, a lubricant and a flow aid. The method comprises the following steps: selecting raw materials, preparing the raw materials, mixing the raw materials, preparing a soft material, pelletizing the material, drying the material, granulating the material, totally blending, and obtaining the finished product. The valsartan / felodipine preparation composition can be used for treating hypertension by oral administration, the valsartan is a specific angiotensin II (AT1) receptor antagonist which has therapeutic effect through oral administration, the felodipine belongs to a third generation calcium antagonist, the product of the invention is the compound preparation of two brand-name drugs for treating hypertension, the compound preparation is suitable for patients who cannot control blood pressure by using a single medicine for treatment, curative effect of the compound preparation is good, usage of medication is convenient, and medication compliance for patients is greatly increased.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a valsartan / felodipine compound preparation and a preparation method thereof. Background technique [0002] Symptoms of high blood pressure vary from person to person. In the early stage, there may be no symptoms or no obvious symptoms, and blood pressure will only increase after fatigue, mental stress, and mood swings, and return to normal after rest. With the prolongation of the course of the disease, the blood pressure continues to rise significantly, and various symptoms will gradually appear. At this time, it is called slow progressive hypertension. The common clinical symptoms of slowly progressive hypertension include headache, dizziness, inattention, memory loss, limb numbness, nocturia, palpitations, chest tightness, and fatigue. When the blood pressure suddenly rises to a certain level, symptoms such as severe headache, vomiting, heart palpitations, and dizziness ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K9/20A61K9/48A61P9/12A61K31/41
Inventor 马玉国张昕任萃文江延辉马凌风王海涛
Owner HARBIN SHENGJI PHARMA
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