Medicine-carrying aquogel coating and preparation method and application thereof

An alumina hydrogel and gel technology, applied in coating, medical science, tissue regeneration, etc., can solve the problems of delayed infection and unsatisfactory bacteriostatic effect, and achieve the effect of preventing delayed infection

Active Publication Date: 2016-03-16
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Nowadays, implant materials are often used in medicine to repair damaged tissues, but it is necessary to prevent the occurrence of tissue sit

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:

[0044] (1) Add 2.5g of aluminum isopropoxide into 50mL of deionized water, stir the white precipitate at 80°C for 15min to obtain a dispersion, ultrasonically treat the dispersion for 2h, and cool to room temperature to obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 2%.

[0045] (2) Dissolve 10 mg of the anti-infective drug penicillin in 1 mL of Tris-hydrochloric acid buffer (concentration 0.05 M) at pH=7.4 to obtain an anti-infective drug solution, and mix 100 μL of the alumina hydrogel obtained in step (1) with 50 μL of the anti-infective drug Mix the solution in a 1.5mL glass tube evenly, then use a pipette gun to take 50μL of the mixed solution on a glass slide (2cm×2cm in size), use a Meyer rod to repeatedly press and coat 5 times to coat evenly, and then put it in a vacuum drying oven ...

Embodiment 2

[0047] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:

[0048] (1) Add 2.5g of aluminum isopropoxide into 25mL of deionized water, stir the white precipitate at 80°C for 30min to obtain a dispersion, ultrasonically treat the dispersion for 1h, and cool to room temperature to obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 3%.

[0049] (2) 10 mg of anti-infective drug erythromycin was dissolved in 2 mL of Tris-hydrochloric acid buffer (concentration 0.05 M) at pH=7.4 to obtain an anti-infective drug solution, and 100 μL of alumina hydrogel obtained in step (1) was mixed with 80 μL of anti-infective drug Mix the infection drug solution in a 1.5mL glass tube evenly, then use a pipette gun to take 50μL of the mixed solution on a glass slide (2cm×2cm in size), use a Meyer rod to repeatedly press 7 times to coat evenly, and then put it in a vacuum Dry ...

Embodiment 3

[0051] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:

[0052] (1) Add 2.5g of aluminum isopropoxide into 75mL of deionized water, stir the white precipitate at 80°C for 20min to obtain a dispersion, ultrasonicate the dispersion for 3h, cool to room temperature, and obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 1%.

[0053] (2) Dissolve 10 mg of the anti-infective drug levofloxacin in 3 mL of Tris-hydrochloride buffer (concentration 0.05 M) at pH=7.4 to obtain an anti-infective drug solution, and mix 100 μL of the alumina hydrogel obtained in step (1) with 30 μL of the anti-infective drug Mix the solution in a 1.5mL glass tube evenly, then use a pipette gun to take 50μL of the mixed solution on a glass slide (2cm×2cm in size), use a Meyer rod to repeatedly press and coat 3 times to coat evenly, and then put it in a vacuum drying oven Dry at med...

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Abstract

The invention provides a medicine-carrying aquogel coating and a preparation method and application thereof. Alumina aquogel serves as a coating substrate and carries anti-infection medicine, and the nanometer medicine-carrying aquogel coating is obtained; due to the characteristics that alumina aquogel is not degraded and is slowly absorbed by human bodies, the anti-infection medicine carried by the medicine-carrying coating can be stored in the coating all the time, and the anti-infection effect of the coating can be achieved continuously; when the coating is applied to an implant material, a composite implant body is obtained and implanted into a human body, and chronic infection especially the chronic infection caused by the implant material can be effectively stopped when damaged parts are repaired.

Description

technical field [0001] The invention belongs to the field of hydrogel preparation, and relates to a drug-loaded hydrogel coating and a preparation method and application thereof. Background technique [0002] Nowadays, implant materials are often used in medicine to repair damaged tissues, but it is necessary to prevent the occurrence of tissue site infection during tissue repair. The antibacterial effect of commonly used tissue repair materials is not ideal, and often causes delayed infection. . Research on medical materials capable of tissue repair has become a hotspot. [0003] Hydrogel is a multi-component system composed of polymers and other materials through a three-dimensional cross-linked network structure and medium. Because of its stable properties, it can respond quickly to small changes in the environment. As a new type of biomedical material, it has attracted the attention of many researchers. focus on. Taking advantage of its good biocompatibility, hydrogel...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/30
CPCA61L27/306A61L27/54A61L2300/104A61L2300/206A61L2300/21A61L2300/216A61L2300/23A61L2300/404A61L2430/02A61L2430/12A61L2430/22A61L2430/24
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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